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Protein
Submitted name:

Sialidase A (Neuraminidase A)

Gene

nanA

Organism
Streptococcus pneumoniae serotype 14 (strain INV200)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSPNE869216:GLL9-1523-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Sialidase A (Neuraminidase A)Imported
Gene namesi
Name:nanAImported
Ordered Locus Names:SPNINV200_15140Imported
OrganismiStreptococcus pneumoniae serotype 14 (strain INV200)Imported
Taxonomic identifieri869216 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008562: Chromosome

Subcellular locationi

Secretedcell wall SAAS annotation; Peptidoglycan-anchor SAAS annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE1XL97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01186.
OMAiGGPKREN.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR001791. Laminin_G.
IPR019931. LPXTG_anchor.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1XL97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSVQERKC RYSIRKLSVG AVSMIVGAVV FGTSPVLAQE GASEQPLANE
60 70 80 90 100
TQLSGESSTL TDTEKSQPSS ETELSGNKQE QERKDKQEEK IPRDYYARDL
110 120 130 140 150
ENVETVIEKE DVETNASNGQ RVDLSSELDK LKKLENATVH MEFKPDAKAP
160 170 180 190 200
AFYNLFSVSS ATKKDEYFTM AVYNNTATLE GRGSDGQQFY GNYNDAPLKV
210 220 230 240 250
KPGQWNSVTF TVEKPTAELP KGRVRLYVNG VLSRTSLKSG NFIKDMPDVT
260 270 280 290 300
HVQIGATKRA NNTVWGSNLQ IRNLTVYNRA LTPEEVQKRS QLFKRSDLEK
310 320 330 340 350
KLPEGAVLTE KTDIFESGRN GKPNKDGIKS YRIPALLKTD KGTLIAGADE
360 370 380 390 400
RRLHSSDWGD IGMVIRRSED NGKTWGDKVV ISNLRDNPEA KDPAAPSPLN
410 420 430 440 450
IDMVLVQDPT TKRIFSIYDM FPEGRAVFGM PKTPEKAYEK IGDKTYQILY
460 470 480 490 500
KQGESGHYTV RENGEVYNAQ NQKTDYRVVV NPTEPGYRDK GNLYKGQELI
510 520 530 540 550
GNIYFAHSTK NPFRVANTSY LWMSYSDDDG KTWSAPRDIT PGLRKDWMKF
560 570 580 590 600
LGTGPGTGIV LRNGPHKGRI LIPVYTTNNV SHLNGSQSSR VIYSDDHGKT
610 620 630 640 650
WHAGEAVNDN RQVDGQKIHS STMNNERAQN TESTVVQLNN GDVKLFMRGL
660 670 680 690 700
TGDLQVATSK DGGVTWEKDI KRYPQVKDVY VQMSAIHTMH EGKEYIILSN
710 720 730 740 750
AGGPKRENGM VHLARVEENG ELTWLKHNPI QKGEFAYNSL QELGNGEYGI
760 770 780 790 800
LYEHTEKGQN AYTLSFRKFN WDFLSKDLIS PTEAKVKRTR EMGKGEMGKG
810 820 830 840 850
VIGLEFDSEV LVNKAPTLQL ANGKTATFLT QYDSKTLLFA VDKEDIGQEI
860 870 880 890 900
IGIAKGSIES MHNLPVNLAG ARVPGGVNGS KAAVHEVPEF TGGVNGTEPA
910 920 930 940 950
VHEIAEYKGS DSLVTLTTKE DYTYKAPLAQ QALPETGNKE SDLLASLGLT
960
AFFLGLFTLG KKREQ
Length:965
Mass (Da):107,260
Last modified:November 30, 2010 - v1
Checksum:i72A0275EEF4DB50C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312029 Genomic DNA. Translation: CBW35147.1.
RefSeqiYP_006066782.1. NC_017593.1.

Genome annotation databases

EnsemblBacteriaiCBW35147; CBW35147; SPNINV200_15140.
GeneIDi12894317.
KEGGisnv:SPNINV200_15140.
PATRICi43227725. VBIStrPne166962_1722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312029 Genomic DNA. Translation: CBW35147.1.
RefSeqiYP_006066782.1. NC_017593.1.

3D structure databases

ProteinModelPortaliE1XL97.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW35147; CBW35147; SPNINV200_15140.
GeneIDi12894317.
KEGGisnv:SPNINV200_15140.
PATRICi43227725. VBIStrPne166962_1722.

Phylogenomic databases

KOiK01186.
OMAiGGPKREN.

Enzyme and pathway databases

BioCyciSPNE869216:GLL9-1523-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR001791. Laminin_G.
IPR019931. LPXTG_anchor.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome."
    Hiller N.L., Janto B., Hogg J.S., Boissy R., Yu S., Powell E., Keefe R., Ehrlich N.E., Shen K., Hayes J., Barbadora K., Klimke W., Dernovoy D., Tatusova T., Parkhill J., Bentley S.D., Post J.C., Ehrlich G.D., Hu F.Z.
    J. Bacteriol. 189:8186-8195(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: INV200Imported.

Entry informationi

Entry nameiE1XL97_STRZN
AccessioniPrimary (citable) accession number: E1XL97
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.