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E1XGC7 (E1XGC7_STRZO) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:SPNOXC09560 EMBL CBW32612.1
OrganismStreptococcus pneumoniae serotype 3 (strain OXC141) [Complete proteome] [HAMAP] EMBL CBW32612.1
Taxonomic identifier869215 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain118 – 313196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding145 – 19955ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2671Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2801Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2801Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E1XGC7 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: E1CD39E03498BF9B

FASTA32135,627
        10         20         30         40         50         60 
MAIIKKIVVL YGGLSEEREV SENSAKEISK SLLTLGYDVI SIDLSQDCSY EIGEIEKSER 

        70         80         90        100        110        120 
GLNKQKVEIG SGIIDVCRKV DIVFLATHGG IGENGKLQAI FDVEKIDYTG NSFLSTAISM 

       130        140        150        160        170        180 
DKKLSKIVAS SVGIKCASNL MVDRIQANDF PIVIKPIRSG SSKGIKIFQN KKQFDIYYKE 

       190        200        210        220        230        240 
HPELGSVFVE KYIKGREFSV GILGETVLPV IEIKVKNGFY DYNNKYTVGA AEEVVPAKIS 

       250        260        270        280        290        300 
EKLTHTLQKS AYKIHKALGF NVYSRTDFIV DEKGDVYFIE SNSLPGMTKT SLLPQEAKAA 

       310        320 
GIDFPNLCER IIELSREIRS Q 

« Hide

References

[1]"Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome."
Hiller N.L., Janto B., Hogg J.S., Boissy R., Yu S., Powell E., Keefe R., Ehrlich N.E., Shen K., Hayes J., Barbadora K., Klimke W., Dernovoy D., Tatusova T., Parkhill J., Bentley S.D., Post J.C., Ehrlich G.D., Hu F.Z.
J. Bacteriol. 189:8186-8195(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: OXC141.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FQ312027 Genomic DNA. Translation: CBW32612.1.
RefSeqYP_006064409.1. NC_017592.1.

3D structure databases

ProteinModelPortalE1XGC7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBW32612; CBW32612; SPNOXC09560.
GeneID12891942.
KEGGsnx:SPNOXC_09560.
PATRIC43231225. VBIStrPne166247_1099.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMADRIQAND.

Enzyme and pathway databases

BioCycSPNE869215:GLLA-960-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE1XGC7_STRZO
AccessionPrimary (citable) accession number: E1XGC7
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)