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E1XCB3

- E1XCB3_STRZO

UniProt

E1XCB3 - E1XCB3_STRZO

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Protein

D-alanine--D-alanine ligase

Gene
ddlA, ddl, SPNOXC14680
Organism
Streptococcus pneumoniae serotype 3 (strain OXC141)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi287 – 2871Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi300 – 3001Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi300 – 3001Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi302 – 3021Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 21656ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE869215:GLLA-1471-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
ORF Names:SPNOXC14680Imported
OrganismiStreptococcus pneumoniae serotype 3 (strain OXC141)Imported
Taxonomic identifieri869215 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008965: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE1XCB3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 333203ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.
OMAiKLAFQYD.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1XCB3-1 [UniParc]FASTAAdd to Basket

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MKQTIILLYG GRSAEREVSV LSAESVMRAV NYDRFTVKTF FISQSGDFIK    50
TQEFSHAPGQ EDRLMTNETI DWDKKVAPSA IYEEGAVVFP VLHGPMGEDG 100
SVQGFLEVLK MPYVGCNILS SSLAMDKITT KRVLESAGIA QVPYVAIVEG 150
DDVTAKIAEV EEKLAYPVFT KPSNMGSSVG ISRSENQEEL RQALKLAFRY 200
DSRVLVEQGV NAREIEVGLL GNYDVKSTLP GEVVKDVAFY DYDAKYIDNK 250
VTMDIPAKIS DDVVAVMRQN AETAFRAIGG LGLSRCDFFY TDKGEIFLNE 300
LNTMPGFTQW SMYPLLWDNM GISYPELIER LVDLAKESFD KREAHLI 347
Length:347
Mass (Da):38,731
Last modified:November 30, 2010 - v1
Checksum:i0820C5C0AC34D524
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312027 Genomic DNA. Translation: CBW33121.1.
RefSeqiYP_006064872.1. NC_017592.1.

Genome annotation databases

EnsemblBacteriaiCBW33121; CBW33121; SPNOXC14680.
GeneIDi12891203.
KEGGisnx:SPNOXC_14680.
PATRICi43232462. VBIStrPne166247_1709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312027 Genomic DNA. Translation: CBW33121.1 .
RefSeqi YP_006064872.1. NC_017592.1.

3D structure databases

ProteinModelPortali E1XCB3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW33121 ; CBW33121 ; SPNOXC14680 .
GeneIDi 12891203.
KEGGi snx:SPNOXC_14680.
PATRICi 43232462. VBIStrPne166247_1709.

Phylogenomic databases

KOi K01921.
OMAi KLAFQYD.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SPNE869215:GLLA-1471-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome."
    Hiller N.L., Janto B., Hogg J.S., Boissy R., Yu S., Powell E., Keefe R., Ehrlich N.E., Shen K., Hayes J., Barbadora K., Klimke W., Dernovoy D., Tatusova T., Parkhill J., Bentley S.D., Post J.C., Ehrlich G.D., Hu F.Z.
    J. Bacteriol. 189:8186-8195(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: OXC141.

Entry informationi

Entry nameiE1XCB3_STRZO
AccessioniPrimary (citable) accession number: E1XCB3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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