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E1XCB3 (E1XCB3_STRZO) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CBW33121.1
Synonyms:ddl HAMAP-Rule MF_00047
ORF Names:SPNOXC14680 EMBL CBW33121.1
OrganismStreptococcus pneumoniae serotype 3 (strain OXC141) [Complete proteome] [HAMAP] EMBL CBW33121.1
Taxonomic identifier869215 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain131 – 333203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding161 – 21656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2871Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3001Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3001Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3021Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E1XCB3 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 0820C5C0AC34D524

FASTA34738,731
        10         20         30         40         50         60 
MKQTIILLYG GRSAEREVSV LSAESVMRAV NYDRFTVKTF FISQSGDFIK TQEFSHAPGQ 

        70         80         90        100        110        120 
EDRLMTNETI DWDKKVAPSA IYEEGAVVFP VLHGPMGEDG SVQGFLEVLK MPYVGCNILS 

       130        140        150        160        170        180 
SSLAMDKITT KRVLESAGIA QVPYVAIVEG DDVTAKIAEV EEKLAYPVFT KPSNMGSSVG 

       190        200        210        220        230        240 
ISRSENQEEL RQALKLAFRY DSRVLVEQGV NAREIEVGLL GNYDVKSTLP GEVVKDVAFY 

       250        260        270        280        290        300 
DYDAKYIDNK VTMDIPAKIS DDVVAVMRQN AETAFRAIGG LGLSRCDFFY TDKGEIFLNE 

       310        320        330        340 
LNTMPGFTQW SMYPLLWDNM GISYPELIER LVDLAKESFD KREAHLI 

« Hide

References

[1]"Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome."
Hiller N.L., Janto B., Hogg J.S., Boissy R., Yu S., Powell E., Keefe R., Ehrlich N.E., Shen K., Hayes J., Barbadora K., Klimke W., Dernovoy D., Tatusova T., Parkhill J., Bentley S.D., Post J.C., Ehrlich G.D., Hu F.Z.
J. Bacteriol. 189:8186-8195(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: OXC141.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FQ312027 Genomic DNA. Translation: CBW33121.1.
RefSeqYP_006064872.1. NC_017592.1.

3D structure databases

ProteinModelPortalE1XCB3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBW33121; CBW33121; SPNOXC14680.
GeneID12891203.
KEGGsnx:SPNOXC_14680.
PATRIC43232462. VBIStrPne166247_1709.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAKLAFQYD.

Enzyme and pathway databases

BioCycSPNE869215:GLLA-1471-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE1XCB3_STRZO
AccessionPrimary (citable) accession number: E1XCB3
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)