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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Haemophilus influenzae (strain 10810)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei125 – 1251UniRule annotation
Active sitei532 – 5321UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciHINF862964:GHI0-1873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:HIB_18150Imported
OrganismiHaemophilus influenzae (strain 10810)Imported
Taxonomic identifieri862964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000008964 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1X8C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRFLGETI NDAQGEDILE LIENIRKLSR NSRAGDDKAR QALLDTLGSI
60 70 80 90 100
SNENIIPVAR AFSQFLNLTN IAEQYQTISR EHSLAQSSSQ SLSELFKRLK
110 120 130 140 150
EQNASVEEVH KTVEKLLIEL VLTAHPTETT RRSLIHKHIE INKCLSKLEH
160 170 180 190 200
HDLTEKERNI IERLLLRLIA EAWHTNEIRT VRPTPFDEAK WGFAMLENSL
210 220 230 240 250
WQAVPEFLRQ LNETAREFLG YDLPVGLKPV RISSWMGGDR DGNPFVTAQI
260 270 280 290 300
TKKVLYFARW KAADLFLQDI SKLADELSMM KCSDEFRDKY GEQLEPYRFV
310 320 330 340 350
VKNLRNQLTA TLAYFDDHLS NRTPRVSESE IILEDNQLWE PLYDCYQSLI
360 370 380 390 400
QCGMRIIANG SLLNILHRIS CFGVTLSQMD IRQESTRHTD AIAEITRYIG
410 420 430 440 450
LGDYSQWMED DKQAFLIREL SSRRPLIPQN WTPSPETKEI LDTCKVIAQQ
460 470 480 490 500
KQGVIACYVI SMARSASDVL AVHLLLKESG VPYHIPVVPL FETLEDLDAA
510 520 530 540 550
EKVMTQLFNV GWYRGVINNR QMVMIGYSDS AKDAGMMAAS WAQYRAQEAL
560 570 580 590 600
VNLTEKLGIE LTLFHGRGGT IGRGGAPAHA ALLSQPPRSL KNGLRVTEQG
610 620 630 640 650
EMIRFKLGLP AVAVETFDLY ASAILEANLL PPPEPKPEWR TIMDELSTIS
660 670 680 690 700
CDIYRGVVRG DKDFVPYFRS ATPEQELSKL PLGSRPAKRN PNGGVESLRA
710 720 730 740 750
IPWIFAWMQN RLMLPAWLGA GAAIRQVIEQ GKGDIIHKMC ENWPFFSTRI
760 770 780 790 800
GMLEMVFSKS DTWLSQQYDQ RLVKKELWYL GENLRKQLED DIQTVLSLSH
810 820 830 840 850
QSELMSDLPW IADSIALRNI YTDPLNLLQV ELLHRFRENP EQVNPDVEQA
860
LMITITGIAA GMRNTG
Length:866
Mass (Da):98,517
Last modified:November 30, 2010 - v1
Checksum:iAC260237A99A07CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312006 Genomic DNA. Translation: CBW30000.1.

Genome annotation databases

EnsemblBacteriaiCBW30000; CBW30000; HIB_18150.
KEGGihiu:HIB_18150.
PATRICi43041120. VBIHaeInf165663_1889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312006 Genomic DNA. Translation: CBW30000.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW30000; CBW30000; HIB_18150.
KEGGihiu:HIB_18150.
PATRICi43041120. VBIHaeInf165663_1889.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciHINF862964:GHI0-1873-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Haemophilus influenzae 10810."
    Crook D., Hood D., Moxon R., Bentley S.D., Aslett M., Parkhill J.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 10810Imported.

Entry informationi

Entry nameiE1X8C5_HAEI1
AccessioniPrimary (citable) accession number: E1X8C5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 22, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.