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E1X754

- E1X754_HAEI1

UniProt

E1X754 - E1X754_HAEI1

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

HIB_13900

Organism
Haemophilus influenzae (strain 10810)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciHINF862964:GHI0-1442-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:HIB_13900Imported
    OrganismiHaemophilus influenzae (strain 10810)Imported
    Taxonomic identifieri862964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000008964: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE1X754.
    SMRiE1X754. Positions 1-80, 108-186, 310-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    KOiK00627.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1X754-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQIQIPDI GSDEVTVTEV MVNVGDTISV DQSIINVEGD KASMEVPAPE    50
    AGVVKEILVK VGDKVSTGTP MLVLEAAGAA PAADEPTAPV ADAPTAPVVA 100
    TAPTASAIVE VNVPDIGGDE VNVTEIMVAV GDTITEEQSL ITVEGDKASM 150
    EVPAPFGGVV KEILVKSGDK VSTGSLIMRF EVLGAAPAES ASASTSAPQA 200
    AAPATTAQAP QAAAPDTTAQ AAQSNNNVSG LSQEQVEAST GYAHATPVIR 250
    RLAREFGVNL DKVKGTGRKG RIVKEDIEAY VKTAVKAYES GATAQATGNG 300
    VANGAGLGLL PWPKVDFSKF GEIEEVELSR INKISGANLH RNWVIIPHVT 350
    HFDKADITDL EAFRKEQNAL AEKQKLGVKI TPVVFIMKAV AKALEAYPRF 400
    NSSITEDAQR LILKKYINIG VAVDTPNGLV VPVFKNVNKK GIIELSRELM 450
    EVSKKAREGK LTASDMQGGC FTISSLGGIG TTHFAPIVNA PEVAILGVSK 500
    SSMEPVWNGK EFAPRLILPM SLSFDHRVID GADGARFISY LGSVLADLRR 550
    LVM 553
    Length:553
    Mass (Da):58,004
    Last modified:November 30, 2010 - v1
    Checksum:iE14013405502D0E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312006 Genomic DNA. Translation: CBW29577.1.
    RefSeqiYP_005179415.1. NC_016809.1.

    Genome annotation databases

    EnsemblBacteriaiCBW29577; CBW29577; HIB_13900.
    GeneIDi11769762.
    KEGGihiu:HIB_13900.
    PATRICi43040215. VBIHaeInf165663_1441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312006 Genomic DNA. Translation: CBW29577.1 .
    RefSeqi YP_005179415.1. NC_016809.1.

    3D structure databases

    ProteinModelPortali E1X754.
    SMRi E1X754. Positions 1-80, 108-186, 310-553.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBW29577 ; CBW29577 ; HIB_13900 .
    GeneIDi 11769762.
    KEGGi hiu:HIB_13900.
    PATRICi 43040215. VBIHaeInf165663_1441.

    Phylogenomic databases

    KOi K00627.

    Enzyme and pathway databases

    BioCyci HINF862964:GHI0-1442-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Haemophilus influenzae 10810."
      Crook D., Hood D., Moxon R., Bentley S.D., Aslett M., Parkhill J.
      Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 10810Imported.

    Entry informationi

    Entry nameiE1X754_HAEI1
    AccessioniPrimary (citable) accession number: E1X754
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3