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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Halobacteriovorax marinus (strain ATCC BAA-682 / DSM 15412 / SJ) (Bacteriovorax marinus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Magnesium or manganese 1UniRule annotation1
Metal bindingi293Magnesium or manganese 1UniRule annotation1
Metal bindingi293Magnesium or manganese 2UniRule annotation1
Metal bindingi295Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMAR862908:G1GWV-1771-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotationImported
Ordered Locus Names:BMS_1867Imported
OrganismiHalobacteriovorax marinus (strain ATCC BAA-682 / DSM 15412 / SJ) (Bacteriovorax marinus)Imported
Taxonomic identifieri862908 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaOligoflexiaBacteriovoracalesHalobacteriovoraceaeHalobacteriovorax
Proteomesi
  • UP000008963 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi862908.BMS_1867

Structurei

3D structure databases

ProteinModelPortaliE1X227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 326ATP-graspInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
KOiK01921
OMAiRCDFFVI
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

E1X227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNILLLCGG GGSEHEVSLR SANYIYDELE KVNLYNVFKV EIKANGDRVD
60 70 80 90 100
HHGQLCELRK AGELYYPSSD QTHKLDFAIP CIHGPPGENG VIQSIFELMG
110 120 130 140 150
LPYLGCSPEP SQTCFNKVST KLWLDALKVP NTPYIYLSDE SRESISAAEE
160 170 180 190 200
FFNANKDVYI KAASQGSSVG CYHVTSLEDL ESTILSAFKF SEYVLIERTL
210 220 230 240 250
KARELEVSAF EYNNEVVITA PGEIICPDGF YDYDQKYSND SATKTEVNAK
260 270 280 290 300
GLSAEQINDI KSYSLKAFKG LKLRHLSRID FFLTEEGKVY LNEINTFPGM
310 320
TSISMFPKMM ENHGVKFSEY LRKIIEEST
Length:329
Mass (Da):37,030
Last modified:November 30, 2010 - v1
Checksum:i93F4D612E4161D96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312005 Genomic DNA Translation: CBW26687.1
RefSeqiWP_014244468.1, NC_016620.1

Genome annotation databases

EnsemblBacteriaiCBW26687; CBW26687; BMS_1867
KEGGibmx:BMS_1867
PATRICifig|862908.3.peg.1772

Similar proteinsi

Entry informationi

Entry nameiE1X227_HALMS
AccessioniPrimary (citable) accession number: E1X227
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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