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E1X227

- E1X227_BACMS

UniProt

E1X227 - E1X227_BACMS

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Protein
D-alanine--D-alanine ligase
Gene
ddl, BMS_1867
Organism
Bacteriovorax marinus (strain ATCC BAA-682 / DSM 15412 / SJ)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi280 – 2801Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi293 – 2931Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi293 – 2931Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi295 – 2951Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20656ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMAR862908:GJBX-1765-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotationImported
Ordered Locus Names:BMS_1867Imported
OrganismiBacteriovorax marinus (strain ATCC BAA-682 / DSM 15412 / SJ)Imported
Taxonomic identifieri862908 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBacteriovoracaceaeBacteriovorax
ProteomesiUP000008963: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE1X227.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 326206ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.
OMAiHNGLLKN.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1X227-1 [UniParc]FASTAAdd to Basket

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MKNILLLCGG GGSEHEVSLR SANYIYDELE KVNLYNVFKV EIKANGDRVD    50
HHGQLCELRK AGELYYPSSD QTHKLDFAIP CIHGPPGENG VIQSIFELMG 100
LPYLGCSPEP SQTCFNKVST KLWLDALKVP NTPYIYLSDE SRESISAAEE 150
FFNANKDVYI KAASQGSSVG CYHVTSLEDL ESTILSAFKF SEYVLIERTL 200
KARELEVSAF EYNNEVVITA PGEIICPDGF YDYDQKYSND SATKTEVNAK 250
GLSAEQINDI KSYSLKAFKG LKLRHLSRID FFLTEEGKVY LNEINTFPGM 300
TSISMFPKMM ENHGVKFSEY LRKIIEEST 329
Length:329
Mass (Da):37,030
Last modified:November 30, 2010 - v1
Checksum:i93F4D612E4161D96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312005 Genomic DNA. Translation: CBW26687.1.
RefSeqiYP_005035652.1. NC_016620.1.

Genome annotation databases

EnsemblBacteriaiCBW26687; CBW26687; BMS_1867.
GeneIDi11549316.
KEGGibmx:BMS_1867.
PATRICi42739739. VBIBacMar168520_1772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312005 Genomic DNA. Translation: CBW26687.1 .
RefSeqi YP_005035652.1. NC_016620.1.

3D structure databases

ProteinModelPortali E1X227.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW26687 ; CBW26687 ; BMS_1867 .
GeneIDi 11549316.
KEGGi bmx:BMS_1867.
PATRICi 42739739. VBIBacMar168520_1772.

Phylogenomic databases

KOi K01921.
OMAi HNGLLKN.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BMAR862908:GJBX-1765-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A small predatory core genome in the divergent marine Bacteriovorax marinus SJ and the terrestrial Bdellovibrio bacteriovorus."
    Crossman L.C., Chen H., Cerdeno-Tarraga A.M., Brooks K., Quail M.A., Pineiro S.A., Hobley L., Sockett R.E., Bentley S.D., Parkhill J., Williams H.N., Stine O.C.
    ISME J. 7:148-160(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-682 / DSM 15412 / SJ.

Entry informationi

Entry nameiE1X227_BACMS
AccessioniPrimary (citable) accession number: E1X227
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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