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Protein

Alanine racemase

Gene

alr

Organism
Bacteriovorax marinus (strain ATCC BAA-682 / DSM 15412 / SJ)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei137 – 1371SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBMAR862908:GJBX-2648-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BMS_2785Imported
OrganismiBacteriovorax marinus (strain ATCC BAA-682 / DSM 15412 / SJ)Imported
Taxonomic identifieri862908 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBacteriovoracaceaeBacteriovorax
ProteomesiUP000008963 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1WY06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiCAYENIV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E1WY06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFRSRHFIS FEKLENNYKK LKEICVDNKI IFMVKANAYG HGVIPIVRHS
60 70 80 90 100
VEKLGITEFG CASLGEALLL REELYDLEFE IYVFSDVQVE LRECAEIYLN
110 120 130 140 150
RRIIPVISNR DDLDFILNSR EFENFPLFIK FNTGMNRLGL EMDKVDEVIR
160 170 180 190 200
SIRVSGRKSI YHLMTHLSSS SLPIKKNKRN IIQFENFEKI KKAFSDAGIE
210 220 230 240 250
VERTSIANSG AIEQGAGLGE THVRPGLMMY GPSSMLPQYS DLSLWSGEII
260 270 280 290 300
SKLETYVISI FDVEKGQPVG YGATPCPSKG KVAIVALGYG DGFTTRYIGT
310 320 330 340 350
HLYHKDIKGK VVGRVNMDMA QVFFDENSLP DLKVGDSFTL WDHSAERFAE
360 370
FCKEAKIIPY EVFIGITQRV PKIYS
Length:375
Mass (Da):42,675
Last modified:November 30, 2010 - v1
Checksum:iD13D3306B5D76302
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312005 Genomic DNA. Translation: CBW27561.1.
RefSeqiYP_005036519.1. NC_016620.1.

Genome annotation databases

EnsemblBacteriaiCBW27561; CBW27561; BMS_2785.
GeneIDi11550197.
KEGGibmx:BMS_2785.
PATRICi42741533. VBIBacMar168520_2661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312005 Genomic DNA. Translation: CBW27561.1.
RefSeqiYP_005036519.1. NC_016620.1.

3D structure databases

ProteinModelPortaliE1WY06.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW27561; CBW27561; BMS_2785.
GeneIDi11550197.
KEGGibmx:BMS_2785.
PATRICi42741533. VBIBacMar168520_2661.

Phylogenomic databases

KOiK01775.
OMAiCAYENIV.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBMAR862908:GJBX-2648-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A small predatory core genome in the divergent marine Bacteriovorax marinus SJ and the terrestrial Bdellovibrio bacteriovorus."
    Crossman L.C., Chen H., Cerdeno-Tarraga A.M., Brooks K., Quail M.A., Pineiro S.A., Hobley L., Sockett R.E., Bentley S.D., Parkhill J., Williams H.N., Stine O.C.
    ISME J. 7:148-160(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-682 / DSM 15412 / SJImported.

Entry informationi

Entry nameiE1WY06_BACMS
AccessioniPrimary (citable) accession number: E1WY06
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.