Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E1WS50

- FTN_BACF6

UniProt

E1WS50 - FTN_BACF6

Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Bacteroides fragilis (strain 638R)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May alleviate iron toxicity in the presence of oxygen.

    Catalytic activityi

    4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
    Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBFRA862962:GHND-2805-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterial non-heme ferritin (EC:1.16.3.2)
    Gene namesi
    Name:ftnA
    Ordered Locus Names:BF638R_2891
    OrganismiBacteroides fragilis (strain 638R)
    Taxonomic identifieri862962 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000008560: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Bacterial non-heme ferritinPRO_0000405241Add
    BLAST

    Expressioni

    Inductioni

    Expression is induced in the presence of excess iron in an oxidative environment but not in reduced anaerobic conditions. Is also regulated by oxyR.1 Publication

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliE1WS50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK02217.
    OMAiSASHAYM.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1WS50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISEKLQNAI NEQISAEMWS SNLYLSMSFY FEREGFSGFA HWMKKQSQEE    50
    MGHAYAMADY IIKRGGIAKV DKIDVVPTGW GTPLEVFEHV FEHERHVSKL 100
    VDALVDIAAA EKDKATQDFL WGFVREQVEE EATAQGIVDK IKRAGDAGIF 150
    FIDSQLGQR 159
    Length:159
    Mass (Da):18,064
    Last modified:November 30, 2010 - v1
    Checksum:i3CAD5FC4984A0AB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028371 Genomic DNA. Translation: AAK29742.1.
    FQ312004 Genomic DNA. Translation: CBW23380.1.
    RefSeqiYP_005111916.1. NC_016776.1.

    Genome annotation databases

    EnsemblBacteriaiCBW23380; CBW23380; BF638R_2891.
    GeneIDi11703326.
    KEGGibfg:BF638R_2891.
    PATRICi42748845. VBIBacFra167533_2972.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028371 Genomic DNA. Translation: AAK29742.1 .
    FQ312004 Genomic DNA. Translation: CBW23380.1 .
    RefSeqi YP_005111916.1. NC_016776.1.

    3D structure databases

    ProteinModelPortali E1WS50.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBW23380 ; CBW23380 ; BF638R_2891 .
    GeneIDi 11703326.
    KEGGi bfg:BF638R_2891.
    PATRICi 42748845. VBIBacFra167533_2972.

    Phylogenomic databases

    KOi K02217.
    OMAi SASHAYM.

    Enzyme and pathway databases

    BioCyci BFRA862962:GHND-2805-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional regulation of the Bacteroides fragilis ferritin gene (ftnA) by redox stress."
      Rocha E.R., Smith C.J.
      Microbiology 150:2125-2134(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTIONAL REGULATION.
      Strain: 638R.
    2. "Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis."
      Patrick S., Blakely G.W., Houston S., Moore J., Abratt V.R., Bertalan M., Cerdeno-Tarraga A.M., Quail M.A., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
      Microbiology 156:3255-3269(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638R.

    Entry informationi

    Entry nameiFTN_BACF6
    AccessioniPrimary (citable) accession number: E1WS50
    Secondary accession number(s): P28733, Q9AEU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3