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E1WS50

- FTN_BACF6

UniProt

E1WS50 - FTN_BACF6

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Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Bacteroides fragilis (strain 638R)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May alleviate iron toxicity in the presence of oxygen.

Catalytic activityi

4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBFRA862962:GHND-2805-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterial non-heme ferritin (EC:1.16.3.2)
Gene namesi
Name:ftnA
Ordered Locus Names:BF638R_2891
OrganismiBacteroides fragilis (strain 638R)
Taxonomic identifieri862962 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000008560: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Bacterial non-heme ferritinPRO_0000405241Add
BLAST

Expressioni

Inductioni

Expression is induced in the presence of excess iron in an oxidative environment but not in reduced anaerobic conditions. Is also regulated by oxyR.1 Publication

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

Structurei

3D structure databases

ProteinModelPortaliE1WS50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK02217.
OMAiSASHAYM.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1WS50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISEKLQNAI NEQISAEMWS SNLYLSMSFY FEREGFSGFA HWMKKQSQEE
60 70 80 90 100
MGHAYAMADY IIKRGGIAKV DKIDVVPTGW GTPLEVFEHV FEHERHVSKL
110 120 130 140 150
VDALVDIAAA EKDKATQDFL WGFVREQVEE EATAQGIVDK IKRAGDAGIF

FIDSQLGQR
Length:159
Mass (Da):18,064
Last modified:November 30, 2010 - v1
Checksum:i3CAD5FC4984A0AB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028371 Genomic DNA. Translation: AAK29742.1.
FQ312004 Genomic DNA. Translation: CBW23380.1.
RefSeqiYP_005111916.1. NC_016776.1.

Genome annotation databases

EnsemblBacteriaiCBW23380; CBW23380; BF638R_2891.
GeneIDi11703326.
KEGGibfg:BF638R_2891.
PATRICi42748845. VBIBacFra167533_2972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028371 Genomic DNA. Translation: AAK29742.1 .
FQ312004 Genomic DNA. Translation: CBW23380.1 .
RefSeqi YP_005111916.1. NC_016776.1.

3D structure databases

ProteinModelPortali E1WS50.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW23380 ; CBW23380 ; BF638R_2891 .
GeneIDi 11703326.
KEGGi bfg:BF638R_2891.
PATRICi 42748845. VBIBacFra167533_2972.

Phylogenomic databases

KOi K02217.
OMAi SASHAYM.

Enzyme and pathway databases

BioCyci BFRA862962:GHND-2805-MONOMER.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional regulation of the Bacteroides fragilis ferritin gene (ftnA) by redox stress."
    Rocha E.R., Smith C.J.
    Microbiology 150:2125-2134(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTIONAL REGULATION.
    Strain: 638R.
  2. "Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis."
    Patrick S., Blakely G.W., Houston S., Moore J., Abratt V.R., Bertalan M., Cerdeno-Tarraga A.M., Quail M.A., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
    Microbiology 156:3255-3269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638R.

Entry informationi

Entry nameiFTN_BACF6
AccessioniPrimary (citable) accession number: E1WS50
Secondary accession number(s): P28733, Q9AEU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3