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E1WS50 (FTN_BACF6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferritin
EC=1.16.3.1
Gene names
Name:ftnA
Ordered Locus Names:BF638R_2891
OrganismBacteroides fragilis (strain 638R) [Complete proteome] [HAMAP]
Taxonomic identifier862962 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May alleviate iron toxicity in the presence of oxygen.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.

Induction

Expression is induced in the presence of excess iron in an oxidative environment but not in reduced anaerobic conditions. Is also regulated by oxyR. Ref.1

Sequence similarities

Belongs to the ferritin family. Prokaryotic subfamily.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Ferritin
PRO_0000405241

Regions

Domain1 – 145145Ferritin-like diiron

Sites

Metal binding171Iron 1 By similarity
Metal binding501Iron 1 By similarity
Metal binding501Iron 2 By similarity
Metal binding531Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding1271Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
E1WS50 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 3CAD5FC4984A0AB9

FASTA15918,064
        10         20         30         40         50         60 
MISEKLQNAI NEQISAEMWS SNLYLSMSFY FEREGFSGFA HWMKKQSQEE MGHAYAMADY 

        70         80         90        100        110        120 
IIKRGGIAKV DKIDVVPTGW GTPLEVFEHV FEHERHVSKL VDALVDIAAA EKDKATQDFL 

       130        140        150 
WGFVREQVEE EATAQGIVDK IKRAGDAGIF FIDSQLGQR

« Hide

References

« Hide 'large scale' references
[1]"Transcriptional regulation of the Bacteroides fragilis ferritin gene (ftnA) by redox stress."
Rocha E.R., Smith C.J.
Microbiology 150:2125-2134(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTIONAL REGULATION.
Strain: 638R.
[2]"Twenty-eight divergent polysaccharide loci linked to within and amongst strain capsule diversity in three strains of Bacteroides fragilis."
Patrick S., Blakely G.W., Houston S., Moore J., Abratt V., Bertalan M., Cerdeno-Tarraga A., Quail M., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY028371 Genomic DNA. Translation: AAK29742.1.
FQ312004 Genomic DNA. Translation: CBW23380.1.
RefSeqYP_005111916.1. NC_016776.1.

3D structure databases

ProteinModelPortalE1WS50.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBW23380; CBW23380; BF638R_2891.
GeneID11703326.
KEGGbfg:BF638R_2891.
PATRIC42748845. VBIBacFra167533_2972.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK02217.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTN_BACF6
AccessionPrimary (citable) accession number: E1WS50
Secondary accession number(s): P28733, Q9AEU4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 30, 2010
Last modified: May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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