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E1WL52

- E1WL52_BACF6

UniProt

E1WL52 - E1WL52_BACF6

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Protein
Thymidine kinase
Gene
tdk, BF638R_0630
Organism
Bacteroides fragilis (strain 638R)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton acceptor By similarityUniRule annotation
Metal bindingi152 – 1521Zinc By similarityUniRule annotation
Metal bindingi155 – 1551Zinc By similarityUniRule annotation
Metal bindingi184 – 1841Zinc By similarityUniRule annotation
Metal bindingi187 – 1871Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308ATP By similarityUniRule annotation
Nucleotide bindingi95 – 984ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciBFRA862962:GHND-607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:BF638R_0630Imported
OrganismiBacteroides fragilis (strain 638R)Imported
Taxonomic identifieri862962 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000008560: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1WL52.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.
OMAiQAICLSC.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

E1WL52-1 [UniParc]FASTAAdd to Basket

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MVLFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRMKRA KFARQRVEIF    50
KPAIDTRYSE GDVVSHDSNS ISSTPIDSSA SILLFTSEID VVGIDEAQFF 100
DSGLIDVCNQ LANNGVRVII AGLDMDFKGV PFGPMPALCA IADEVSKVHA 150
ICVKCGQLAS FSHRTVKNDK QVLLGETAQY EPLCRECYQR ALQEDREKS 199
Length:199
Mass (Da):22,207
Last modified:November 30, 2010 - v1
Checksum:i39B1FA503FA9E16A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312004 Genomic DNA. Translation: CBW21215.1.
RefSeqiYP_005109766.1. NC_016776.1.

Genome annotation databases

EnsemblBacteriaiCBW21215; CBW21215; BF638R_0630.
GeneIDi11704326.
KEGGibfg:BF638R_0630.
PATRICi42744154. VBIBacFra167533_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312004 Genomic DNA. Translation: CBW21215.1 .
RefSeqi YP_005109766.1. NC_016776.1.

3D structure databases

ProteinModelPortali E1WL52.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW21215 ; CBW21215 ; BF638R_0630 .
GeneIDi 11704326.
KEGGi bfg:BF638R_0630.
PATRICi 42744154. VBIBacFra167533_0650.

Phylogenomic databases

KOi K00857.
OMAi QAICLSC.

Enzyme and pathway databases

BioCyci BFRA862962:GHND-607-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis."
    Patrick S., Blakely G.W., Houston S., Moore J., Abratt V.R., Bertalan M., Cerdeno-Tarraga A.M., Quail M.A., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
    Microbiology 156:3255-3269(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638RImported.

Entry informationi

Entry nameiE1WL52_BACF6
AccessioniPrimary (citable) accession number: E1WL52
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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