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E1WL52

- E1WL52_BACF6

UniProt

E1WL52 - E1WL52_BACF6

Protein

Thymidine kinase

Gene

tdk

Organism
Bacteroides fragilis (strain 638R)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei96 – 961Proton acceptorUniRule annotation
    Metal bindingi152 – 1521ZincUniRule annotation
    Metal bindingi155 – 1551ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 308ATPUniRule annotation
    Nucleotide bindingi95 – 984ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciBFRA862962:GHND-607-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:BF638R_0630Imported
    OrganismiBacteroides fragilis (strain 638R)Imported
    Taxonomic identifieri862962 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000008560: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE1WL52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.
    OMAiQAICLSC.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E1WL52-1 [UniParc]FASTAAdd to Basket

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    MVLFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRMKRA KFARQRVEIF    50
    KPAIDTRYSE GDVVSHDSNS ISSTPIDSSA SILLFTSEID VVGIDEAQFF 100
    DSGLIDVCNQ LANNGVRVII AGLDMDFKGV PFGPMPALCA IADEVSKVHA 150
    ICVKCGQLAS FSHRTVKNDK QVLLGETAQY EPLCRECYQR ALQEDREKS 199
    Length:199
    Mass (Da):22,207
    Last modified:November 30, 2010 - v1
    Checksum:i39B1FA503FA9E16A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312004 Genomic DNA. Translation: CBW21215.1.
    RefSeqiYP_005109766.1. NC_016776.1.

    Genome annotation databases

    EnsemblBacteriaiCBW21215; CBW21215; BF638R_0630.
    GeneIDi11704326.
    KEGGibfg:BF638R_0630.
    PATRICi42744154. VBIBacFra167533_0650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312004 Genomic DNA. Translation: CBW21215.1 .
    RefSeqi YP_005109766.1. NC_016776.1.

    3D structure databases

    ProteinModelPortali E1WL52.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBW21215 ; CBW21215 ; BF638R_0630 .
    GeneIDi 11704326.
    KEGGi bfg:BF638R_0630.
    PATRICi 42744154. VBIBacFra167533_0650.

    Phylogenomic databases

    KOi K00857.
    OMAi QAICLSC.

    Enzyme and pathway databases

    BioCyci BFRA862962:GHND-607-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis."
      Patrick S., Blakely G.W., Houston S., Moore J., Abratt V.R., Bertalan M., Cerdeno-Tarraga A.M., Quail M.A., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
      Microbiology 156:3255-3269(2010)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638RImported.

    Entry informationi

    Entry nameiE1WL52_BACF6
    AccessioniPrimary (citable) accession number: E1WL52
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3