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E1WL52

- E1WL52_BACF6

UniProt

E1WL52 - E1WL52_BACF6

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Protein

Thymidine kinase

Gene

tdk

Organism
Bacteroides fragilis (strain 638R)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi152 – 1521ZincUniRule annotation
Metal bindingi155 – 1551ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation
Metal bindingi187 – 1871ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308ATPUniRule annotation
Nucleotide bindingi95 – 984ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciBFRA862962:GHND-607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:BF638R_0630Imported
OrganismiBacteroides fragilis (strain 638R)Imported
Taxonomic identifieri862962 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000008560: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1WL52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiQAICLSC.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

E1WL52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRMKRA KFARQRVEIF
60 70 80 90 100
KPAIDTRYSE GDVVSHDSNS ISSTPIDSSA SILLFTSEID VVGIDEAQFF
110 120 130 140 150
DSGLIDVCNQ LANNGVRVII AGLDMDFKGV PFGPMPALCA IADEVSKVHA
160 170 180 190
ICVKCGQLAS FSHRTVKNDK QVLLGETAQY EPLCRECYQR ALQEDREKS
Length:199
Mass (Da):22,207
Last modified:November 30, 2010 - v1
Checksum:i39B1FA503FA9E16A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312004 Genomic DNA. Translation: CBW21215.1.
RefSeqiYP_005109766.1. NC_016776.1.

Genome annotation databases

EnsemblBacteriaiCBW21215; CBW21215; BF638R_0630.
GeneIDi11704326.
KEGGibfg:BF638R_0630.
PATRICi42744154. VBIBacFra167533_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312004 Genomic DNA. Translation: CBW21215.1 .
RefSeqi YP_005109766.1. NC_016776.1.

3D structure databases

ProteinModelPortali E1WL52.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW21215 ; CBW21215 ; BF638R_0630 .
GeneIDi 11704326.
KEGGi bfg:BF638R_0630.
PATRICi 42744154. VBIBacFra167533_0650.

Phylogenomic databases

KOi K00857.
OMAi QAICLSC.

Enzyme and pathway databases

BioCyci BFRA862962:GHND-607-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis."
    Patrick S., Blakely G.W., Houston S., Moore J., Abratt V.R., Bertalan M., Cerdeno-Tarraga A.M., Quail M.A., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
    Microbiology 156:3255-3269(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638RImported.

Entry informationi

Entry nameiE1WL52_BACF6
AccessioniPrimary (citable) accession number: E1WL52
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3