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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Bacteroides fragilis (strain 638R)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciBFRA862962:GHND-441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:BF638R_0459Imported
OrganismiBacteroides fragilis (strain 638R)Imported
Taxonomic identifieri862962 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000008560: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1WKP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiDPDLVWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

E1WKP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLNFRKGD AKTEAFGSNR MLQPSPVEKI PDGPTTPEIA YQMVKDETFA
60 70 80 90 100
QTQPRLNLAT FVTTYMDDYA TKLMNEAINI NYIDETEYPR IAVMNGKCIN
110 120 130 140 150
IVANLWNSPE KDTWKTGALA IGSSEACMLG GVAAWLRWRK KRQAQGKPFD
160 170 180 190 200
KPNFVISTGF QVVWEKFAQL WQIEMRQVPL TLDKTTLDPE EALKMCDENT
210 220 230 240 250
ICVVPIQGVT WTGLNDDVEA LDKALDAYNA KTGYDIPIHV DAASGGFILP
260 270 280 290 300
FLYPDTKWDF RLKWVLSISV SGHKFGLVYP GLGWVVWKGK EYLPEEMAFS
310 320 330 340 350
VNYLGANITQ VGLNFSRPAA QILGQYYQFI RLGFQGYKEV QYNSLQIAKY
360 370 380 390 400
IHSQIAKMTP FVNYSEDVVN PLFIWYMKPE YAKNAKWTLY DLQDKLAQHG
410 420 430 440 450
WMVPAYTLPA KLQDYVVMRV VVRQGFSRDM ADMLLGDIKN AIAELEKLEY
460 470 480
PTSTRIAQEK NLPVEAKVFN HTGKPQAAKK
Length:480
Mass (Da):54,594
Last modified:November 30, 2010 - v1
Checksum:i2D028490E1BA5B09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312004 Genomic DNA. Translation: CBW21055.1.
RefSeqiYP_005109606.1. NC_016776.1.

Genome annotation databases

EnsemblBacteriaiCBW21055; CBW21055; BF638R_0459.
GeneIDi11705300.
KEGGibfg:BF638R_0459.
PATRICi42743784. VBIBacFra167533_0471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312004 Genomic DNA. Translation: CBW21055.1.
RefSeqiYP_005109606.1. NC_016776.1.

3D structure databases

ProteinModelPortaliE1WKP2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBW21055; CBW21055; BF638R_0459.
GeneIDi11705300.
KEGGibfg:BF638R_0459.
PATRICi42743784. VBIBacFra167533_0471.

Phylogenomic databases

KOiK01580.
OMAiDPDLVWD.

Enzyme and pathway databases

BioCyciBFRA862962:GHND-441-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis."
    Patrick S., Blakely G.W., Houston S., Moore J., Abratt V.R., Bertalan M., Cerdeno-Tarraga A.M., Quail M.A., Corton N., Corton C., Bignell A., Barron A., Clark L., Bentley S.D., Parkhill J.
    Microbiology 156:3255-3269(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638RImported.

Entry informationi

Entry nameiE1WKP2_BACF6
AccessioniPrimary (citable) accession number: E1WKP2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.