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E1WGG8

- OTSA_SALTS

UniProt

E1WGG8 - OTSA_SALTS

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

otsA

Organism
Salmonella typhimurium (strain SL1344)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor (By similarity).By similarity

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glucose-6-phosphateBy similarity
Binding sitei76 – 761Glucose-6-phosphateBy similarity
Sitei85 – 851Involved in alpha anomer selectivityBy similarity
Binding sitei130 – 1301Glucose-6-phosphateBy similarity
Sitei155 – 1551Involved in alpha anomer selectivityBy similarity
Binding sitei262 – 2621UDP-glucoseBy similarity
Binding sitei267 – 2671UDP-glucoseBy similarity
Binding sitei300 – 3001Glucose-6-phosphateBy similarity
Binding sitei339 – 3391UDP-glucose; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSENT216597:GJB7-1885-MONOMER.
UniPathwayiUPA00299.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Osmoregulatory trehalose synthesis protein A
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:otsA
Ordered Locus Names:SL1344_1862
OrganismiSalmonella typhimurium (strain SL1344)
Taxonomic identifieri216597 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008962: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 473472Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000405417Add
BLAST

Proteomic databases

PRIDEiE1WGG8.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliE1WGG8.
SMRiE1WGG8. Positions 2-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 222UDP-glucose bindingBy similarity
Regioni365 – 3695UDP-glucose bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

OMAiWGESFVK.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E1WGG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRLVVVSNR IAPPDNKGGA GGLAVGVLGA LKAAGGLWFG WSGETGNEDE
60 70 80 90 100
PLKKVTKGNI TWASFNLSEQ DYEDYYCQFS NAVLWPAFHY RLDLVQFQRP
110 120 130 140 150
AWEGYMRVNA LLADKLLPLI KENDIIWVHD YHLLPFASEL RKRGVNNRIG
160 170 180 190 200
FFLHIPFPTP EIFNALPPHD ELLEQLCDFD LLGFQTENDR LAFLDSLSSQ
210 220 230 240 250
TRVTTRSGKQ HIAWGKDFQT EVYPIGIEPD EIALQAAGPL PPKLAQLKAE
260 270 280 290 300
LKNVKNIFSV ERLDYSKGLP ERFLAYEALL ENYPQHRGKI RYTQIAPTSR
310 320 330 340 350
GEVQAYQDIR HQLETEAGRI NGKYGQLGWT PLYYLNQHFD RKLLMKIFRY
360 370 380 390 400
SDVGLVTPLR DGMNLVAKEF VAAQDPANPG VLVLSQFAGA ANELTSALIV
410 420 430 440 450
NPYDRDDVAA ALNRALTMPL AERISRHAEM LDVIVKNDIN RWQERFIHDL
460 470
KEVTPRSPER QQQNNVATFP KLA
Length:473
Mass (Da):53,581
Last modified:November 30, 2010 - v1
Checksum:iE85B3F0AE58E144A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF213176 Genomic DNA. Translation: AAF34582.1.
FQ312003 Genomic DNA. Translation: CBW17956.1.
RefSeqiYP_005181756.1. NC_016810.1.

Genome annotation databases

EnsemblBacteriaiCBW17956; CBW17956; SL1344_1862.
PATRICi43189451. VBISalEnt88447_2067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF213176 Genomic DNA. Translation: AAF34582.1 .
FQ312003 Genomic DNA. Translation: CBW17956.1 .
RefSeqi YP_005181756.1. NC_016810.1.

3D structure databases

ProteinModelPortali E1WGG8.
SMRi E1WGG8. Positions 2-456.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E1WGG8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW17956 ; CBW17956 ; SL1344_1862 .
PATRICi 43189451. VBISalEnt88447_2067.

Phylogenomic databases

OMAi WGESFVK.

Enzyme and pathway databases

UniPathwayi UPA00299 .
BioCyci SENT216597:GJB7-1885-MONOMER.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Trehalose biosynthesis operon in S. typhimurium."
    Howells A.M., Bullifent H.L., Dhaliwal K., Griffin K., Frith G., Tunnacliffe A., Titball R.W.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SL1344.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL1344.

Entry informationi

Entry nameiOTSA_SALTS
AccessioniPrimary (citable) accession number: E1WGG8
Secondary accession number(s): P0A1Q0, Q9L893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 30, 2010
Last modified: October 1, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3