Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E1WGF1 (PBP2_SALTS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Penicillin-binding protein 2

Short name=PBP-2
Gene names
Name:mrdA
Synonyms:pbpA
Ordered Locus Names:SL1344_1845
OrganismSalmonella typhimurium (strain SL1344) [Complete proteome] [HAMAP]
Taxonomic identifier216597 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Domain

Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits) By similarity.

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623Penicillin-binding protein 2
PRO_0000405425

Sites

Active site3261Acyl-ester intermediate By similarity

Experimental info

Sequence conflict621P → A in AAC44611. Ref.2
Sequence conflict1031P → R in AAC44611. Ref.2

Sequences

Sequence LengthMass (Da)Tools
E1WGF1 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: F59E950C293A5E71

FASTA62369,833
        10         20         30         40         50         60 
MTFKDFDAEE KLFLRRVIVA FGVVVVCFGI LIFNLYNLQI RQHHYYTTRS NENDIKMLPV 

        70         80         90        100        110        120 
APTRGIIYDR NGIPLVRNVT WYDIAVTPYK IADMDALLKQ LTPIVDLSPD DISDFRRALK 

       130        140        150        160        170        180 
SSSRYRPVVL KNALTDVEIA RFAVNQFHFN GVTINSYQDR QYPYGAELAH VLGYVSKIND 

       190        200        210        220        230        240 
NDLKALDKKG LAENYAADHN IGKQGIERYY ENDLHGKTGY QEVEVDNHGR IVRLLKDVPP 

       250        260        270        280        290        300 
IAGKNIHLTL DLHLQEYIES LLAGQRAAVL VEDPHDGSVL AMVSMPSYDP NPFVKGISYQ 

       310        320        330        340        350        360 
DYGKLLHDKN LPLINRVTQG LYPPASTVKP YMAMSALLCG IITPQTTFFG APTWTLPGTQ 

       370        380        390        400        410        420 
RHYRDWKKTG HGMLDVTKAI EESADTFFYQ VAYMMGIDRI DTMLSQFGYG KPTGIDLNEE 

       430        440        450        460        470        480 
YDGLLPSRAW KQRVHKKAWY QGDTISVGIG QGYWIATPIQ MVKAMVALIN NGKVIAPHLL 

       490        500        510        520        530        540 
LNEESGKTVV PYRPSGTPAQ IADPASPYWG LVRQAMYGMA NAPNGTGYKF FHTAPYGIAA 

       550        560        570        580        590        600 
KSGTSQVFSL KENQTYNAKM IPIRLRDHVF YTAFAPYKNP KVAIALILEN GGSDGVTAAP 

       610        620 
IMRKILDHLF DPQADTTQPD QAP 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium."
Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K., Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A., Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S., Ussery D.W., Dorman C.J. expand/collapse author list , Thomson N.R., Vogel J., Hinton J.C.
Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SL1344.
[2]"Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction."
Valdivia R.H., Falkow S.
Mol. Microbiol. 22:367-378(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.
Strain: SL1344.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FQ312003 Genomic DNA. Translation: CBW17939.1.
U62714 Genomic DNA. Translation: AAC44611.1.
RefSeqYP_005181739.1. NC_016810.1.

3D structure databases

ProteinModelPortalE1WGF1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBW17939; CBW17939; SL1344_1845.
PATRIC43189413. VBISalEnt88447_2048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMANQNDIKM.

Enzyme and pathway databases

BioCycSENT216597:GJB7-1868-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03423. pbp2_mrdA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePBP2_SALTS
AccessionPrimary (citable) accession number: E1WGF1
Secondary accession number(s): P74872
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 30, 2010
Last modified: February 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways