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E1WGF1

- PBP2_SALTS

UniProt

E1WGF1 - PBP2_SALTS

Protein

Penicillin-binding protein 2

Gene

mrdA

Organism
Salmonella typhimurium (strain SL1344)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei326 – 3261Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. catalytic activity Source: UniProtKB-KW
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSENT216597:GJB7-1868-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 2
    Short name:
    PBP-2
    Gene namesi
    Name:mrdA
    Synonyms:pbpA
    Ordered Locus Names:SL1344_1845
    OrganismiSalmonella typhimurium (strain SL1344)
    Taxonomic identifieri216597 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008962: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623Penicillin-binding protein 2PRO_0000405425Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliE1WGF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).By similarity

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiGKQGIEG.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    IPR017790. Penicillin-binding_protein_2.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E1WGF1-1 [UniParc]FASTAAdd to Basket

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    MTFKDFDAEE KLFLRRVIVA FGVVVVCFGI LIFNLYNLQI RQHHYYTTRS    50
    NENDIKMLPV APTRGIIYDR NGIPLVRNVT WYDIAVTPYK IADMDALLKQ 100
    LTPIVDLSPD DISDFRRALK SSSRYRPVVL KNALTDVEIA RFAVNQFHFN 150
    GVTINSYQDR QYPYGAELAH VLGYVSKIND NDLKALDKKG LAENYAADHN 200
    IGKQGIERYY ENDLHGKTGY QEVEVDNHGR IVRLLKDVPP IAGKNIHLTL 250
    DLHLQEYIES LLAGQRAAVL VEDPHDGSVL AMVSMPSYDP NPFVKGISYQ 300
    DYGKLLHDKN LPLINRVTQG LYPPASTVKP YMAMSALLCG IITPQTTFFG 350
    APTWTLPGTQ RHYRDWKKTG HGMLDVTKAI EESADTFFYQ VAYMMGIDRI 400
    DTMLSQFGYG KPTGIDLNEE YDGLLPSRAW KQRVHKKAWY QGDTISVGIG 450
    QGYWIATPIQ MVKAMVALIN NGKVIAPHLL LNEESGKTVV PYRPSGTPAQ 500
    IADPASPYWG LVRQAMYGMA NAPNGTGYKF FHTAPYGIAA KSGTSQVFSL 550
    KENQTYNAKM IPIRLRDHVF YTAFAPYKNP KVAIALILEN GGSDGVTAAP 600
    IMRKILDHLF DPQADTTQPD QAP 623
    Length:623
    Mass (Da):69,833
    Last modified:November 30, 2010 - v1
    Checksum:iF59E950C293A5E71
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621P → A in AAC44611. (PubMed:8930920)Curated
    Sequence conflicti103 – 1031P → R in AAC44611. (PubMed:8930920)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312003 Genomic DNA. Translation: CBW17939.1.
    U62714 Genomic DNA. Translation: AAC44611.1.
    RefSeqiYP_005181739.1. NC_016810.1.

    Genome annotation databases

    EnsemblBacteriaiCBW17939; CBW17939; SL1344_1845.
    PATRICi43189413. VBISalEnt88447_2048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312003 Genomic DNA. Translation: CBW17939.1 .
    U62714 Genomic DNA. Translation: AAC44611.1 .
    RefSeqi YP_005181739.1. NC_016810.1.

    3D structure databases

    ProteinModelPortali E1WGF1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBW17939 ; CBW17939 ; SL1344_1845 .
    PATRICi 43189413. VBISalEnt88447_2048.

    Phylogenomic databases

    OMAi GKQGIEG.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SENT216597:GJB7-1868-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    IPR017790. Penicillin-binding_protein_2.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03423. pbp2_mrdA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SL1344.
    2. "Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction."
      Valdivia R.H., Falkow S.
      Mol. Microbiol. 22:367-378(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.
      Strain: SL1344.

    Entry informationi

    Entry nameiPBP2_SALTS
    AccessioniPrimary (citable) accession number: E1WGF1
    Secondary accession number(s): P74872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3