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E1WGF1

- PBP2_SALTS

UniProt

E1WGF1 - PBP2_SALTS

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Protein
Penicillin-binding protein 2
Gene
mrdA, pbpA, SL1344_1845
Organism
Salmonella typhimurium (strain SL1344)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei326 – 3261Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. catalytic activity Source: UniProtKB-KW
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  2. regulation of cell shape Source: UniProtKB-KW
  3. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSENT216597:GJB7-1868-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 2
Short name:
PBP-2
Gene namesi
Name:mrdA
Synonyms:pbpA
Ordered Locus Names:SL1344_1845
OrganismiSalmonella typhimurium (strain SL1344)
Taxonomic identifieri216597 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008962: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Penicillin-binding protein 2
PRO_0000405425Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE1WGF1.

Family & Domainsi

Domaini

Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits) By similarity.

Sequence similaritiesi

Belongs to the transpeptidase family.

Phylogenomic databases

OMAiGKQGIEG.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

E1WGF1-1 [UniParc]FASTAAdd to Basket

« Hide

MTFKDFDAEE KLFLRRVIVA FGVVVVCFGI LIFNLYNLQI RQHHYYTTRS    50
NENDIKMLPV APTRGIIYDR NGIPLVRNVT WYDIAVTPYK IADMDALLKQ 100
LTPIVDLSPD DISDFRRALK SSSRYRPVVL KNALTDVEIA RFAVNQFHFN 150
GVTINSYQDR QYPYGAELAH VLGYVSKIND NDLKALDKKG LAENYAADHN 200
IGKQGIERYY ENDLHGKTGY QEVEVDNHGR IVRLLKDVPP IAGKNIHLTL 250
DLHLQEYIES LLAGQRAAVL VEDPHDGSVL AMVSMPSYDP NPFVKGISYQ 300
DYGKLLHDKN LPLINRVTQG LYPPASTVKP YMAMSALLCG IITPQTTFFG 350
APTWTLPGTQ RHYRDWKKTG HGMLDVTKAI EESADTFFYQ VAYMMGIDRI 400
DTMLSQFGYG KPTGIDLNEE YDGLLPSRAW KQRVHKKAWY QGDTISVGIG 450
QGYWIATPIQ MVKAMVALIN NGKVIAPHLL LNEESGKTVV PYRPSGTPAQ 500
IADPASPYWG LVRQAMYGMA NAPNGTGYKF FHTAPYGIAA KSGTSQVFSL 550
KENQTYNAKM IPIRLRDHVF YTAFAPYKNP KVAIALILEN GGSDGVTAAP 600
IMRKILDHLF DPQADTTQPD QAP 623
Length:623
Mass (Da):69,833
Last modified:November 30, 2010 - v1
Checksum:iF59E950C293A5E71
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621P → A in AAC44611. 1 Publication
Sequence conflicti103 – 1031P → R in AAC44611. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312003 Genomic DNA. Translation: CBW17939.1.
U62714 Genomic DNA. Translation: AAC44611.1.
RefSeqiYP_005181739.1. NC_016810.1.

Genome annotation databases

EnsemblBacteriaiCBW17939; CBW17939; SL1344_1845.
PATRICi43189413. VBISalEnt88447_2048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312003 Genomic DNA. Translation: CBW17939.1 .
U62714 Genomic DNA. Translation: AAC44611.1 .
RefSeqi YP_005181739.1. NC_016810.1.

3D structure databases

ProteinModelPortali E1WGF1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW17939 ; CBW17939 ; SL1344_1845 .
PATRICi 43189413. VBISalEnt88447_2048.

Phylogenomic databases

OMAi GKQGIEG.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SENT216597:GJB7-1868-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view ]
Pfami PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03423. pbp2_mrdA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL1344.
  2. "Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction."
    Valdivia R.H., Falkow S.
    Mol. Microbiol. 22:367-378(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.
    Strain: SL1344.

Entry informationi

Entry nameiPBP2_SALTS
AccessioniPrimary (citable) accession number: E1WGF1
Secondary accession number(s): P74872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 30, 2010
Last modified: May 14, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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