argS

Functionⁱ

Catalytic activityⁱ

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functionⁱ

arginine-tRNA ligase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arginyl-tRNA aminoacylation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arginine--tRNA ligase (EC:6.1.1.19) Alternative name(s): Arginyl-tRNA synthetase Short name: ArgRS
Gene namesⁱ	Name:argS Ordered Locus Names:SL1344_1844
Organismⁱ	Salmonella typhimurium (strain SL1344)
Taxonomic identifierⁱ	216597 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium
Proteomesⁱ	UP000008962 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm By similarity

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000406087	1 – 577	Arginine--tRNA ligaseAdd BLAST		577

Proteomic databases

PRIDEⁱ	E1WGF0

PRIDEⁱ

E1WGF0

Interactionⁱ

Subunit structureⁱ

Monomer.By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E1WGF0
SMRⁱ	E1WGF0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	122 – 132	"HIGH" regionAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01887
OMAⁱ	NKPLHLG

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00671 ArgRS_core, 1 hit
Gene3Dⁱ	3.30.1360.70, 1 hit 3.40.50.620, 1 hit
HAMAPⁱ	MF_00123 Arg_tRNA_synth, 1 hit
InterProⁱ	View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR001278 Arg-tRNA-ligase IPR005148 Arg-tRNA-synth_N IPR036695 Arg-tRNA-synth_N_sf IPR035684 ArgRS_core IPR008909 DALR_anticod-bd IPR014729 Rossmann-like_a/b/a_fold IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERⁱ	PTHR11956 PTHR11956, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485 Arg_tRNA_synt_N, 1 hit PF05746 DALR_1, 1 hit PF00750 tRNA-synt_1d, 1 hit
PRINTSⁱ	PR01038 TRNASYNTHARG
SMARTⁱ	View protein in SMART SM01016 Arg_tRNA_synt_N, 1 hit SM00836 DALR_1, 1 hit
SUPFAMⁱ	SSF47323 SSF47323, 1 hit SSF55190 SSF55190, 1 hit
TIGRFAMsⁱ	TIGR00456 argS, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

E1WGF0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNIQALLSEK VSQAMIAAGA PADCEPQVRQ SAKVQFGDYQ ANGMMAVAKK 
        60         70         80         90        100
LGMAPRQLAE QVLTHLDLSG IASKVEIAGP GFINIFLEPA FLAEQVQQAL 
       110        120        130        140        150
ASDRLGVSQP TRQTIVVDYS APNVAKEMHV GHLRSTIIGD AAVRTLEFLG 
       160        170        180        190        200
HHVIRANHVG DWGTQFGMLI AWLEKQQQEN AGDMALADLE GFYRDAKKHY 
       210        220        230        240        250
DEDEAFAERA RNYVVKLQSG DTYFREMWRK LVDITMTQNQ ITYDRLNVTL 
       260        270        280        290        300
TRDDVMGESL YNPMLPGIVA DLKAKGLAVE SEGATVVFLD EFKNKEGDPM 
       310        320        330        340        350
GVIIQKKDGG YLYTTTDIAC AKYRYETLHA DRVLYYIDSR QHQHLMQAWT 
       360        370        380        390        400
IVRKAGYVPD SVPLEHHMFG MMLGKDGKPF KTRAGGTVKL ADLLDEALER 
       410        420        430        440        450
ARRLVAEKNP DMPADELEKL ANAVGIGAVK YADLSKNRTT DYIFDWDNML 
       460        470        480        490        500
AFEGNTAPYM QYAYTRVLSV FRKANIDEQA LASAPVIISE DREAQLAARL 
       510        520        530        540        550
LQFEETLTVV AREGTPHVMC AYLYDVAGLF SGFYEHCPIL SAENDAVRNS 
       560        570 
RLKLAQLTAK TLKLGLDTLG IETVERM

Length:577

Mass (Da):64,275

Last modified:November 30, 2010 - v1

Checksum:ⁱ842D46DD38EB44B7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	491	D → H in AAC44610 (PubMed:8930920).Curated	1
Sequence conflictⁱ	498	A → D in AAC44610 (PubMed:8930920).Curated	1
Sequence conflictⁱ	555	A → V in AAC44610 (PubMed:8930920).Curated	1
Sequence conflictⁱ	569	L → S in AAC44610 (PubMed:8930920).Curated	1
Sequence conflictⁱ	574	V → A in AAC44610 (PubMed:8930920).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FQ312003 Genomic DNA Translation: CBW17938.1 U62714 Genomic DNA Translation: AAC44610.1
NCBI Reference Sequences More...RefSeqⁱ	WP_001025361.1, NC_016810.1

Genome annotation databases

EnsemblBacteriaⁱ	CBW17938; CBW17938; SL1344_1844
KEGGⁱ	sey:SL1344_1844
PATRICⁱ	fig\|216597.6.peg.2047

Protein	Similar proteins		Species	Score	Length
E1WGF0	Arginine--tRNA ligase	)	SALTY		577
Arginine--tRNA ligase		Salmonella enterica subsp. enterica serovar Heidelberg		577
Arginine--tRNA ligase		SALET		577
Arginine--tRNA ligase		SALCE		577
Arginine--tRNA ligase		SALT4		577
+11

Protein	Similar proteins		Species	Score	Length
E1WGF0	Arginine--tRNA ligase	)	KLEP7		577
Arginine--tRNA ligase		KLEPN		577
Arginine--tRNA ligase		Klebsiella pneumoniae subsp. pneumoniae		577
Arginine--tRNA ligase		KLEPH		577
Arginine--tRNA ligase		Klebsiella pneumoniae IS39		577
+1375

Protein	Similar proteins		Species	Score	Length
E1WGF0	Arginine--tRNA ligase		VIBCH		577
Arginine--tRNA ligase		VIBCL		577
Arginine--tRNA ligase		Vibrio metoecus		599
Arginine--tRNA ligase		Vibrio cholerae O1 biovar El Tor		599
Arginine--tRNA ligase		VIBCO		599
+3542

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FQ312003 Genomic DNA Translation: CBW17938.1 U62714 Genomic DNA Translation: AAC44610.1
NCBI Reference Sequences More...RefSeqⁱ	WP_001025361.1, NC_016810.1

3D structure databases

ProteinModelPortalⁱ	E1WGF0
SMRⁱ	E1WGF0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	E1WGF0

PRIDEⁱ

E1WGF0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CBW17938; CBW17938; SL1344_1844
KEGGⁱ	sey:SL1344_1844
PATRICⁱ	fig\|216597.6.peg.2047

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01887
OMAⁱ	NKPLHLG

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00671 ArgRS_core, 1 hit
Gene3Dⁱ	3.30.1360.70, 1 hit 3.40.50.620, 1 hit
HAMAPⁱ	MF_00123 Arg_tRNA_synth, 1 hit
InterProⁱ	View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR001278 Arg-tRNA-ligase IPR005148 Arg-tRNA-synth_N IPR036695 Arg-tRNA-synth_N_sf IPR035684 ArgRS_core IPR008909 DALR_anticod-bd IPR014729 Rossmann-like_a/b/a_fold IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERⁱ	PTHR11956 PTHR11956, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485 Arg_tRNA_synt_N, 1 hit PF05746 DALR_1, 1 hit PF00750 tRNA-synt_1d, 1 hit
PRINTSⁱ	PR01038 TRNASYNTHARG
SMARTⁱ	View protein in SMART SM01016 Arg_tRNA_synt_N, 1 hit SM00836 DALR_1, 1 hit
SUPFAMⁱ	SSF47323 SSF47323, 1 hit SSF55190 SSF55190, 1 hit
TIGRFAMsⁱ	TIGR00456 argS, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYR_SALTS
Accessionⁱ	E1WGF0Primary (citable) accession number: E1WGF0 Secondary accession number(s): P74871
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
	Last sequence update:	November 30, 2010
	Last modified:	May 23, 2018
	This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - E1WGF0 (SYR_SALTS)

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Arginine--tRNA ligase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ