UniProtKB - E1WGF0 (SYR_SALTS)
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Protein
Arginine--tRNA ligase
Gene
argS
Organism
Salmonella typhimurium (strain SL1344)
Status
Functioni
Catalytic activityi
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
GO - Molecular functioni
- arginine-tRNA ligase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- arginyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Arginine--tRNA ligase (EC:6.1.1.19)Alternative name(s): Arginyl-tRNA synthetase Short name: ArgRS |
Gene namesi | Name:argS Ordered Locus Names:SL1344_1844 |
Organismi | Salmonella typhimurium (strain SL1344) |
Taxonomic identifieri | 216597 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000406087 | 1 – 577 | Arginine--tRNA ligaseAdd BLAST | 577 |
Interactioni
Subunit structurei
Monomer.By similarity
Structurei
3D structure databases
ProteinModelPortali | E1WGF0. |
SMRi | E1WGF0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 122 – 132 | "HIGH" regionAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
KOi | K01887. |
OMAi | NKPLHLG. |
Family and domain databases
CDDi | cd00671. ArgRS_core. 1 hit. |
Gene3Di | 3.30.1360.70. 1 hit. 3.40.50.620. 1 hit. |
HAMAPi | MF_00123. Arg_tRNA_synth. 1 hit. |
InterProi | View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase. IPR005148. Arg-tRNA-synth_N. IPR036695. Arg-tRNA-synth_N_sf. IPR035684. ArgRS_core. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd. |
PANTHERi | PTHR11956. PTHR11956. 1 hit. |
Pfami | View protein in Pfam PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. |
PRINTSi | PR01038. TRNASYNTHARG. |
SMARTi | View protein in SMART SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. |
SUPFAMi | SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit. |
TIGRFAMsi | TIGR00456. argS. 1 hit. |
PROSITEi | View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
E1WGF0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIQALLSEK VSQAMIAAGA PADCEPQVRQ SAKVQFGDYQ ANGMMAVAKK
60 70 80 90 100
LGMAPRQLAE QVLTHLDLSG IASKVEIAGP GFINIFLEPA FLAEQVQQAL
110 120 130 140 150
ASDRLGVSQP TRQTIVVDYS APNVAKEMHV GHLRSTIIGD AAVRTLEFLG
160 170 180 190 200
HHVIRANHVG DWGTQFGMLI AWLEKQQQEN AGDMALADLE GFYRDAKKHY
210 220 230 240 250
DEDEAFAERA RNYVVKLQSG DTYFREMWRK LVDITMTQNQ ITYDRLNVTL
260 270 280 290 300
TRDDVMGESL YNPMLPGIVA DLKAKGLAVE SEGATVVFLD EFKNKEGDPM
310 320 330 340 350
GVIIQKKDGG YLYTTTDIAC AKYRYETLHA DRVLYYIDSR QHQHLMQAWT
360 370 380 390 400
IVRKAGYVPD SVPLEHHMFG MMLGKDGKPF KTRAGGTVKL ADLLDEALER
410 420 430 440 450
ARRLVAEKNP DMPADELEKL ANAVGIGAVK YADLSKNRTT DYIFDWDNML
460 470 480 490 500
AFEGNTAPYM QYAYTRVLSV FRKANIDEQA LASAPVIISE DREAQLAARL
510 520 530 540 550
LQFEETLTVV AREGTPHVMC AYLYDVAGLF SGFYEHCPIL SAENDAVRNS
560 570
RLKLAQLTAK TLKLGLDTLG IETVERM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 491 | D → H in AAC44610 (PubMed:8930920).Curated | 1 | |
Sequence conflicti | 498 | A → D in AAC44610 (PubMed:8930920).Curated | 1 | |
Sequence conflicti | 555 | A → V in AAC44610 (PubMed:8930920).Curated | 1 | |
Sequence conflicti | 569 | L → S in AAC44610 (PubMed:8930920).Curated | 1 | |
Sequence conflicti | 574 | V → A in AAC44610 (PubMed:8930920).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FQ312003 Genomic DNA. Translation: CBW17938.1. U62714 Genomic DNA. Translation: AAC44610.1. |
RefSeqi | WP_001025361.1. NC_016810.1. |
Genome annotation databases
EnsemblBacteriai | CBW17938; CBW17938; SL1344_1844. |
KEGGi | sey:SL1344_1844. |
PATRICi | fig|216597.6.peg.2047. |
Similar proteinsi
Entry informationi
Entry namei | SYR_SALTS | |
Accessioni | E1WGF0Primary (citable) accession number: E1WGF0 Secondary accession number(s): P74871 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 28, 2018 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |