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E1WET7

- E1WET7_SALTS

UniProt

E1WET7 - E1WET7_SALTS

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Protein

Alanine racemase

Gene

alr-b

Organism
Salmonella typhimurium (strain SL1344)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Active sitei255 – 2551Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSENT216597:GJB7-4268-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr-bImported
Ordered Locus Names:SL1344_4183Imported
OrganismiSalmonella typhimurium (strain SL1344)Imported
Taxonomic identifieri216597 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008962: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiE1WET7.

Structurei

3D structure databases

ProteinModelPortaliE1WET7.
SMRiE1WET7. Positions 1-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1WET7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQAATVVINR RALRHNLQRL RELAPASKLV AVVKANAYGH GLLETARTLP
60 70 80 90 100
DADAFGVARL EEALRLRAGG ITQPILLLEG FFDAADLPTI SAQCLHTAVH
110 120 130 140 150
NQEQLAALEA VELAEPVTVW MKLDTGMHRL GVRPEEAEAF YQRLTHCKNV
160 170 180 190 200
RQPVNIVSHF ARADEPECGA TEHQLDIFNA FCQGKPGQRS IAASGGILLW
210 220 230 240 250
PQSHFDWARP GIILYGVSPL EHKPWGPDFG FQPVMSLTSS LIAVRDHKAG
260 270 280 290 300
EPVGYGGTWV SERDTRLGVV AMGYGDGYPR AAPSGTPVLV NGREVPIVGR
310 320 330 340 350
VAMDMICVDL GPNAQDNAGD PVVLWGEGLP VERIAEMTKV SAYELITRLT

SRVAMKYID
Length:359
Mass (Da):39,076
Last modified:November 30, 2010 - v1
Checksum:iB6527AED8263D65B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312003 Genomic DNA. Translation: CBW20270.1.
RefSeqiYP_005184048.1. NC_016810.1.

Genome annotation databases

EnsemblBacteriaiCBW20270; CBW20270; SL1344_4183.
PATRICi43194752. VBISalEnt88447_4658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312003 Genomic DNA. Translation: CBW20270.1 .
RefSeqi YP_005184048.1. NC_016810.1.

3D structure databases

ProteinModelPortali E1WET7.
SMRi E1WET7. Positions 1-359.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E1WET7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW20270 ; CBW20270 ; SL1344_4183 .
PATRICi 43194752. VBISalEnt88447_4658.

Phylogenomic databases

OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SENT216597:GJB7-4268-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Salmonella enterica subsp. enterica serovar Typhimurium SL1344."
    Dougan G., Barrow P., Achtman M., Parkhill J., Thomson N.R.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL1344.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL1344Imported.

Entry informationi

Entry nameiE1WET7_SALTS
AccessioniPrimary (citable) accession number: E1WET7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3