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E1W818

- AMPD_SALTS

UniProt

E1W818 - AMPD_SALTS

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Protein
1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
Gene
ampD, SL1344_0146
Organism
Salmonella typhimurium (strain SL1344)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc; required for amidase activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Zinc; catalytic By similarity
Active sitei116 – 1161Proton acceptor By similarity
Metal bindingi154 – 1541Zinc; catalytic By similarity
Sitei162 – 1621Transition state stabilizer By similarity
Metal bindingi164 – 1641Zinc; catalytic By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT216597:GJB7-148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD (EC:3.5.1.28)
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene namesi
Name:ampD
Ordered Locus Names:SL1344_0146
OrganismiSalmonella typhimurium (strain SL1344)
Taxonomic identifieri216597 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008962: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1871871,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
PRO_0000405414Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliE1W818.
SMRiE1W818. Positions 1-187.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiCEDRAWH.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

E1W818-1 [UniParc]FASTAAdd to Basket

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MLPDKGWLVE ARRVPSPHYD CRPDDEKPSL LVVHNISLPP GEFGGPWIDA    50
LFTGTIDPDA HPFFAEIAHL RVSAHCLIRR DGEIVQYVPF DKRAWHAGVS 100
NYQGRERCND FSIGIELEGT DTLAYTDAQY QQLAAVTRTL IASYPAIADN 150
MTGHCNIAPD RKTDPGPAFD WPRFRALVAL SSHKEMT 187
Length:187
Mass (Da):20,913
Last modified:November 30, 2010 - v1
Checksum:i9E7EBAC553AEDFE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ242516 Genomic DNA. Translation: CAB89835.1.
FQ312003 Genomic DNA. Translation: CBW16249.1.
RefSeqiYP_005180083.1. NC_016810.1.

Genome annotation databases

EnsemblBacteriaiCBW16249; CBW16249; SL1344_0146.
PATRICi43185606. VBISalEnt88447_0162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ242516 Genomic DNA. Translation: CAB89835.1 .
FQ312003 Genomic DNA. Translation: CBW16249.1 .
RefSeqi YP_005180083.1. NC_016810.1.

3D structure databases

ProteinModelPortali E1W818.
SMRi E1W818. Positions 1-187.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW16249 ; CBW16249 ; SL1344_0146 .
PATRICi 43185606. VBISalEnt88447_0162.

Phylogenomic databases

OMAi CEDRAWH.

Enzyme and pathway databases

BioCyci SENT216597:GJB7-148-MONOMER.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
[Graphical view ]
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a Salmonella-specific region located between ampE and aroP genes."
    Cano D., Casadesus J., Garcia-del Portillo F.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SL1344.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL1344.

Entry informationi

Entry nameiAMPD_SALTS
AccessioniPrimary (citable) accession number: E1W818
Secondary accession number(s): P30013, Q9L4I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 30, 2010
Last modified: May 14, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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