SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E1W6P3

- E1W6P3_HAEP3

UniProt

E1W6P3 - E1W6P3_HAEP3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene
PARA_19370
Organism
Haemophilus parainfluenzae (strain T3T1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciHPAR862965:GH07-1988-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:PARA_19370Imported
OrganismiHaemophilus parainfluenzae (strain T3T1)Imported
Taxonomic identifieri862965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000007052: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 3 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotations

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1W6P3-1 [UniParc]FASTAAdd to Basket

« Hide

MSKQIQIPDI GSDEVTVTEV MVKVGDTITA DQSIINVEGD KASMEVPAPE    50
AGVVKEVLVK VGDKVTTGTP MLVLESAEAA APAPAAAAPA PAAAPAAASV 100
VEVNVPDIGS DEVNVTDIMV KVGDTVEVDQ SIINVEGDKA SMEVPAPVAG 150
VVKEILINVG DKVVTGKLIM KFEVAGAAPA AAPAQQAAAP AAAPTPTPTA 200
SAIKEVNVPD IGGDEVNVTE IMVAVGDSVS EEQSLITVEG DKASMEVPAP 250
FAGVVKEILV KSGDKVSTGS LIMKFEVAGA APAPAAAPAA AAPAHQAAPA 300
AAPAAQSGNV SGLSQEQVVA SAGYAHATPV IRRLAREYGI NLDRVKGTGR 350
KGRVVKEDIQ AYVKTAVKAF ETGTVSSAAA GNGVANGAGL GLLPWPKVDF 400
SKFGEVEEVE LSRINKISGA NLHRNWVMIP HVTHFDRTDI TDLEAFRKEQ 450
NKIVEKQKLD VKITPVVFIM KAVAKALEAF PRFNSSISED GQKLTLKKYI 500
NIGVAVDTPN GLVVPVFKNV NKKGIIELSR ELMEISKKAR DGKLSGSDMQ 550
GGCFTISSLG GIGTTHFTPI VNAPEVAILG VSKSEMQPVW NGKEFEPRLM 600
LPLSLSFDHR VIDGADGARF LSYINGVLAD LRRLVM 636
Length:636
Mass (Da):66,203
Last modified:November 30, 2010 - v1
Checksum:i648C4DB6AFF7C682
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312002 Genomic DNA. Translation: CBW16037.1.
RefSeqiYP_004823623.1. NC_015964.1.

Genome annotation databases

EnsemblBacteriaiCBW16037; CBW16037; PARA_19370.
GeneIDi11115707.
KEGGihpr:PARA_19370.
PATRICi43053066. VBIHaePar168133_1929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ312002 Genomic DNA. Translation: CBW16037.1 .
RefSeqi YP_004823623.1. NC_015964.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW16037 ; CBW16037 ; PARA_19370 .
GeneIDi 11115707.
KEGGi hpr:PARA_19370.
PATRICi 43053066. VBIHaePar168133_1929.

Phylogenomic databases

KOi K00627.

Enzyme and pathway databases

BioCyci HPAR862965:GH07-1988-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Haemophilus parainfluenzae T3T1."
    Crook D., Hood D., Moxon R., Parkhill J., Aslett M., Bentley S.D.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T3T1.

Entry informationi

Entry nameiE1W6P3_HAEP3
AccessioniPrimary (citable) accession number: E1W6P3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi