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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

PARA_19370

Organism
Haemophilus parainfluenzae (strain T3T1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandPyruvateImported

Enzyme and pathway databases

BioCyciHPAR862965:G1GWU-1988-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:PARA_19370Imported
OrganismiHaemophilus parainfluenzae (strain T3T1)Imported
Taxonomic identifieri862965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000007052 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi862965.PARA_19370

Structurei

3D structure databases

ProteinModelPortaliE1W6P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 75Lipoyl-bindingInterPro annotationAdd BLAST74
Domaini100 – 173Lipoyl-bindingInterPro annotationAdd BLAST74
Domaini203 – 276Lipoyl-bindingInterPro annotationAdd BLAST74
Domaini326 – 363Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN Bacteria
COG0508 LUCA
KOiK00627
OMAiTMEFESF
OrthoDBiPOG091H05OF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 4 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 3 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 3 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 3 hits
PS00189 LIPOYL, 3 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

E1W6P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQIQIPDI GSDEVTVTEV MVKVGDTITA DQSIINVEGD KASMEVPAPE
60 70 80 90 100
AGVVKEVLVK VGDKVTTGTP MLVLESAEAA APAPAAAAPA PAAAPAAASV
110 120 130 140 150
VEVNVPDIGS DEVNVTDIMV KVGDTVEVDQ SIINVEGDKA SMEVPAPVAG
160 170 180 190 200
VVKEILINVG DKVVTGKLIM KFEVAGAAPA AAPAQQAAAP AAAPTPTPTA
210 220 230 240 250
SAIKEVNVPD IGGDEVNVTE IMVAVGDSVS EEQSLITVEG DKASMEVPAP
260 270 280 290 300
FAGVVKEILV KSGDKVSTGS LIMKFEVAGA APAPAAAPAA AAPAHQAAPA
310 320 330 340 350
AAPAAQSGNV SGLSQEQVVA SAGYAHATPV IRRLAREYGI NLDRVKGTGR
360 370 380 390 400
KGRVVKEDIQ AYVKTAVKAF ETGTVSSAAA GNGVANGAGL GLLPWPKVDF
410 420 430 440 450
SKFGEVEEVE LSRINKISGA NLHRNWVMIP HVTHFDRTDI TDLEAFRKEQ
460 470 480 490 500
NKIVEKQKLD VKITPVVFIM KAVAKALEAF PRFNSSISED GQKLTLKKYI
510 520 530 540 550
NIGVAVDTPN GLVVPVFKNV NKKGIIELSR ELMEISKKAR DGKLSGSDMQ
560 570 580 590 600
GGCFTISSLG GIGTTHFTPI VNAPEVAILG VSKSEMQPVW NGKEFEPRLM
610 620 630
LPLSLSFDHR VIDGADGARF LSYINGVLAD LRRLVM
Length:636
Mass (Da):66,203
Last modified:November 30, 2010 - v1
Checksum:i648C4DB6AFF7C682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ312002 Genomic DNA Translation: CBW16037.1
RefSeqiWP_014065650.1, NC_015964.1

Genome annotation databases

EnsemblBacteriaiCBW16037; CBW16037; PARA_19370
KEGGihpr:PARA_19370
PATRICifig|862965.3.peg.1929

Entry informationi

Entry nameiE1W6P3_HAEP3
AccessioniPrimary (citable) accession number: E1W6P3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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