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E1W6P3

- E1W6P3_HAEP3

UniProt

E1W6P3 - E1W6P3_HAEP3

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

PARA_19370

Organism
Haemophilus parainfluenzae (strain T3T1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciHPAR862965:GH07-1988-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:PARA_19370Imported
    OrganismiHaemophilus parainfluenzae (strain T3T1)Imported
    Taxonomic identifieri862965 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000007052: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    KOiK00627.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 3 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 3 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
    PS00189. LIPOYL. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1W6P3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQIQIPDI GSDEVTVTEV MVKVGDTITA DQSIINVEGD KASMEVPAPE    50
    AGVVKEVLVK VGDKVTTGTP MLVLESAEAA APAPAAAAPA PAAAPAAASV 100
    VEVNVPDIGS DEVNVTDIMV KVGDTVEVDQ SIINVEGDKA SMEVPAPVAG 150
    VVKEILINVG DKVVTGKLIM KFEVAGAAPA AAPAQQAAAP AAAPTPTPTA 200
    SAIKEVNVPD IGGDEVNVTE IMVAVGDSVS EEQSLITVEG DKASMEVPAP 250
    FAGVVKEILV KSGDKVSTGS LIMKFEVAGA APAPAAAPAA AAPAHQAAPA 300
    AAPAAQSGNV SGLSQEQVVA SAGYAHATPV IRRLAREYGI NLDRVKGTGR 350
    KGRVVKEDIQ AYVKTAVKAF ETGTVSSAAA GNGVANGAGL GLLPWPKVDF 400
    SKFGEVEEVE LSRINKISGA NLHRNWVMIP HVTHFDRTDI TDLEAFRKEQ 450
    NKIVEKQKLD VKITPVVFIM KAVAKALEAF PRFNSSISED GQKLTLKKYI 500
    NIGVAVDTPN GLVVPVFKNV NKKGIIELSR ELMEISKKAR DGKLSGSDMQ 550
    GGCFTISSLG GIGTTHFTPI VNAPEVAILG VSKSEMQPVW NGKEFEPRLM 600
    LPLSLSFDHR VIDGADGARF LSYINGVLAD LRRLVM 636
    Length:636
    Mass (Da):66,203
    Last modified:November 30, 2010 - v1
    Checksum:i648C4DB6AFF7C682
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312002 Genomic DNA. Translation: CBW16037.1.
    RefSeqiYP_004823623.1. NC_015964.1.

    Genome annotation databases

    EnsemblBacteriaiCBW16037; CBW16037; PARA_19370.
    GeneIDi11115707.
    KEGGihpr:PARA_19370.
    PATRICi43053066. VBIHaePar168133_1929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312002 Genomic DNA. Translation: CBW16037.1 .
    RefSeqi YP_004823623.1. NC_015964.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBW16037 ; CBW16037 ; PARA_19370 .
    GeneIDi 11115707.
    KEGGi hpr:PARA_19370.
    PATRICi 43053066. VBIHaePar168133_1929.

    Phylogenomic databases

    KOi K00627.

    Enzyme and pathway databases

    BioCyci HPAR862965:GH07-1988-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 3 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 3 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 3 hits.
    PS00189. LIPOYL. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Haemophilus parainfluenzae T3T1."
      Crook D., Hood D., Moxon R., Parkhill J., Aslett M., Bentley S.D.
      Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T3T1Imported.

    Entry informationi

    Entry nameiE1W6P3_HAEP3
    AccessioniPrimary (citable) accession number: E1W6P3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3