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E1W4R5 (E1W4R5_HAEP3) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:PARA_12540 EMBL CBW15357.1
OrganismHaemophilus parainfluenzae (strain T3T1) [Complete proteome] [HAMAP] EMBL CBW15357.1
Taxonomic identifier862965 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 303200ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding134 – 18956ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2571Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2721Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E1W4R5 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 9B5D5872DC696617

FASTA30633,204
        10         20         30         40         50         60 
MNLKQEKIAV LLGGTSAERE VSLNSGAAVL NALVSQGYNA HGIDPKEYNV ANLKADGFDR 

        70         80         90        100        110        120 
VFNILHGRGG EDGTMQGLLE QIGLPYTGCG VMASALTMDK MRTKMLWKAF GLPVADMEIV 

       130        140        150        160        170        180 
TKENANELNP QAVVEKLGLP LMVKPSLEGS SVGLTKVKAV EELKSAVDYA LKFDNTILIE 

       190        200        210        220        230        240 
EWLAGDELTV PVLGGEVLPA VRIVPEGEFY DYDAKYISDN TQYFCPAGLS VEREQELAKL 

       250        260        270        280        290        300 
VKRAYDVVGC RGWSRIDVMT DAQGNFRLVE VNTNPGMTSH SLFPKSASTV GISFEQLVVK 


ILELSA 

« Hide

References

[1]"The genome sequence of Haemophilus parainfluenzae T3T1."
Crook D., Hood D., Moxon R., Parkhill J., Aslett M., Bentley S.D.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T3T1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FQ312002 Genomic DNA. Translation: CBW15357.1.
RefSeqYP_004822945.1. NC_015964.1.

3D structure databases

ProteinModelPortalE1W4R5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBW15357; CBW15357; PARA_12540.
GeneID11117103.
KEGGhpr:PARA_12540.
PATRIC43051662. VBIHaePar168133_1254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycHPAR862965:GH07-1285-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE1W4R5_HAEP3
AccessionPrimary (citable) accession number: E1W4R5
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)