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E1W3A7

- APHA_HAEP3

UniProt

E1W3A7 - APHA_HAEP3

Protein

Class B acid phosphatase

Gene

aphA

Organism
Haemophilus parainfluenzae (strain T3T1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.By similarity

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671NucleophileBy similarity
    Metal bindingi67 – 671MagnesiumBy similarity
    Active sitei69 – 691Proton donorBy similarity
    Metal bindingi69 – 691Magnesium; via carbonyl oxygenBy similarity
    Binding sitei175 – 1751SubstrateBy similarity
    Metal bindingi190 – 1901MagnesiumBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciHPAR862965:GH07-756-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class B acid phosphataseImportedBy similarity (EC:3.1.3.2By similarity)
    Short name:
    CBAPBy similarity
    Gene namesi
    Name:aphABy similarity
    Ordered Locus Names:PARA_07400
    OrganismiHaemophilus parainfluenzae (strain T3T1)
    Taxonomic identifieri862965 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000007052: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 235213Class B acid phosphataseSequence AnalysisPRO_0000415226Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliE1W3A7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1362Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class B bacterial acid phosphatase family.By similarity

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK03788.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view]
    PfamiPF03767. Acid_phosphat_B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01672. AphA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E1W3A7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNLLKLSAI AILAASAVST FASNKEPYTE QGTNAREMTE QKPIHWISVE    50
    QLKKELEGKA PINVSFDIDD TVLFSSPCFY HGQEKYSPGK NDYLKNQDFW 100
    NEVNAGCDQY SIPKQIAVDL INMHQARGDQ IYFITGRTAG DKDGVTPVLQ 150
    KAFNIKDMHP VEFMGGRKLP TKYNKTPGII EHKVSIHYGD SDDDILAAKE 200
    AGIRGIRLMR AANSTYQPMP TLGGYGEEVL INSNY 235
    Length:235
    Mass (Da):26,222
    Last modified:November 30, 2010 - v1
    Checksum:i6F39B06DD55F912C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312002 Genomic DNA. Translation: CBW14847.1.
    RefSeqiYP_004822438.1. NC_015964.1.

    Genome annotation databases

    EnsemblBacteriaiCBW14847; CBW14847; PARA_07400.
    GeneIDi11116604.
    KEGGihpr:PARA_07400.
    PATRICi43050586. VBIHaePar168133_0738.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ312002 Genomic DNA. Translation: CBW14847.1 .
    RefSeqi YP_004822438.1. NC_015964.1.

    3D structure databases

    ProteinModelPortali E1W3A7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBW14847 ; CBW14847 ; PARA_07400 .
    GeneIDi 11116604.
    KEGGi hpr:PARA_07400.
    PATRICi 43050586. VBIHaePar168133_0738.

    Phylogenomic databases

    KOi K03788.

    Enzyme and pathway databases

    BioCyci HPAR862965:GH07-756-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view ]
    Pfami PF03767. Acid_phosphat_B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01672. AphA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Haemophilus parainfluenzae T3T1."
      Crook D., Hood D., Moxon R., Parkhill J., Aslett M., Bentley S.D.
      Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T3T1.

    Entry informationi

    Entry nameiAPHA_HAEP3
    AccessioniPrimary (citable) accession number: E1W3A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3