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Protein

Alanine racemase

Gene

alr

Organism
Arthrobacter arilaitensis (strain DSM 16368 / CIP 108037 / JCM 13566 / Re117)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei285 – 2851Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei332 – 3321Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAARI861360:GI6T-2504-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:AARI_23060Imported
OrganismiArthrobacter arilaitensis (strain DSM 16368 / CIP 108037 / JCM 13566 / Re117)Imported
Taxonomic identifieri861360 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000006878 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1VY23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1VY23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSEALEESN LTNSTSSAQA TGFERRAVID LSAIRNNVKQ ISDVVAPAAV
60 70 80 90 100
MAVVKADAYG HGAIQVAKAA LEGGARWIGC AHVTEALALR EAGIDAPMLA
110 120 130 140 150
WLHTEDTPFE AAIDAGLDLG VSGWELERVA AAARAVQTPA RIHIKVDTGL
160 170 180 190 200
GRNGSTMEAL PDLLNRASDF QEEGLLRAVG IFSHLAVADE PERPETDEQL
210 220 230 240 250
AVFNTAIELI EAAGFDLEVR HIANTPGILS RPDSHYEMVR LGLGLYGLSP
260 270 280 290 300
FEEDTPQSFG LRPAMTVKTR VANVKKVRPG QGVSYGLNYK TEGETYLGLI
310 320 330 340 350
PMGYADGLPR IATGAPVTVN GRTYPVRGRI AMDQCVIDLG ADINPEDFLG
360 370 380 390
AEAIIFGDGG QSVNTWAYAA NTINYEVVTR ISPRVPRYYI EGSWGEAGE
Length:399
Mass (Da):42,689
Last modified:November 30, 2010 - v1
Checksum:i4E26069039B3EB1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ311875 Genomic DNA. Translation: CBT76526.1.
RefSeqiWP_013349643.1. NC_014550.1.
YP_003917497.1. NC_014550.1.

Genome annotation databases

EnsemblBacteriaiCBT76526; CBT76526; AARI_23060.
KEGGiaai:AARI_23060.
PATRICi42171489. VBIArtAri166201_2462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ311875 Genomic DNA. Translation: CBT76526.1.
RefSeqiWP_013349643.1. NC_014550.1.
YP_003917497.1. NC_014550.1.

3D structure databases

ProteinModelPortaliE1VY23.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBT76526; CBT76526; AARI_23060.
KEGGiaai:AARI_23060.
PATRICi42171489. VBIArtAri166201_2462.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciAARI861360:GI6T-2504-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The arthrobacter arilaitensis Re117 genome sequence reveals its genetic adaptation to the surface of cheese."
    Monnet C., Loux V., Gibrat J.F., Spinnler E., Barbe V., Vacherie B., Gavory F., Gourbeyre E., Siguier P., Chandler M., Elleuch R., Irlinger F., Vallaeys T.
    PLoS ONE 5:e15489-e15489(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 16368 / CIP 108037 / JCM 13566 / Re117Imported.
  2. "Complete genome sequence of Arthrobacter arilaitensis (strain DSM 16368 / CIP 108037 / JCM 13566 / Re117)."
    Genoscope.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16368 / CIP 108037 / JCM 13566 / Re117Imported.

Entry informationi

Entry nameiE1VY23_ARTAR
AccessioniPrimary (citable) accession number: E1VY23
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 27, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.