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E1VK08

- E1VK08_9GAMM

UniProt

E1VK08 - E1VK08_9GAMM

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
gamma proteobacterium HdN1
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciGPRO83406:GIWA-1605-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    ORF Names:HDN1F_15670Imported
    Organismigamma proteobacterium HdN1Imported
    Taxonomic identifieri83406 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteria
    ProteomesiUP000002677: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE1VK08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1VK08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYQKIKVPA DGDKITVNAD LSLNVPNYPV IPFIEGDGIG VDITPVMLKV    50
    VNAAVEKAYG TKRAISWMEV YCGEKATKVY GPDVWLPEET LDVLREYIVS 100
    IKGPLTTPVG GGIRSLNVAL RQELDLYVCQ RPVRWFKGVP SPVTSPHKTD 150
    MVIFRENSED IYAGIEWKAD SPEAIKIIKF LQEEMGVKKI RFTEHCGIGI 200
    KPVSKEGTQR LVRKAIQYAI DNDEPSVTFV HKGNIMKYTE GAFKEWGYEL 250
    AQERFGAELL DGGPWMTMKN PKTGRDIIIK DVIADAFLQQ ILMRPEEYSI 300
    IATLNLNGDY ISDALAAEVG GIGIAPGANI GGSVAMFEAT HGTAPKYAGQ 350
    DKVNPGSLIL SAEMMLRHMG WTEAADLIIR GMEGSIEAKT VTYDFERLMP 400
    NATLLRCSEF GDALIRHME 419
    Length:419
    Mass (Da):46,291
    Last modified:November 30, 2010 - v1
    Checksum:iF7F69599C3EA32C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929140 Genomic DNA. Translation: CBL45150.1.
    RefSeqiWP_013261644.1. NC_014366.1.
    YP_003810802.1. NC_014366.1.

    Genome annotation databases

    EnsemblBacteriaiCBL45150; CBL45150; HDN1F_15670.
    GeneIDi9700866.
    KEGGigpb:HDN1F_15670.
    PATRICi42346105. VBIGamPro61291_1703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929140 Genomic DNA. Translation: CBL45150.1 .
    RefSeqi WP_013261644.1. NC_014366.1.
    YP_003810802.1. NC_014366.1.

    3D structure databases

    ProteinModelPortali E1VK08.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBL45150 ; CBL45150 ; HDN1F_15670 .
    GeneIDi 9700866.
    KEGGi gpb:HDN1F_15670.
    PATRICi 42346105. VBIGamPro61291_1703.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci GPRO83406:GIWA-1605-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alkane degradation by a new type of denitrifying bacterium with possible involvement of the electron acceptor in substrate activation."
      Widdel F., Rabus R., Grundmann O., Werner I., Schreiber F., Ehrenreich P., Behrends A., Wilkes H., Kube M., Reinhardt R., Zedelius J.
      Environ. Microbiol. 0:0-0(2010)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiE1VK08_9GAMM
    AccessioniPrimary (citable) accession number: E1VK08
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3