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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
gamma proteobacterium HdN1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciGPRO83406:GIWA-1605-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:HDN1F_15670Imported
Organismigamma proteobacterium HdN1Imported
Taxonomic identifieri83406 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteria
ProteomesiUP000002677 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1VK08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1VK08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYQKIKVPA DGDKITVNAD LSLNVPNYPV IPFIEGDGIG VDITPVMLKV
60 70 80 90 100
VNAAVEKAYG TKRAISWMEV YCGEKATKVY GPDVWLPEET LDVLREYIVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQELDLYVCQ RPVRWFKGVP SPVTSPHKTD
160 170 180 190 200
MVIFRENSED IYAGIEWKAD SPEAIKIIKF LQEEMGVKKI RFTEHCGIGI
210 220 230 240 250
KPVSKEGTQR LVRKAIQYAI DNDEPSVTFV HKGNIMKYTE GAFKEWGYEL
260 270 280 290 300
AQERFGAELL DGGPWMTMKN PKTGRDIIIK DVIADAFLQQ ILMRPEEYSI
310 320 330 340 350
IATLNLNGDY ISDALAAEVG GIGIAPGANI GGSVAMFEAT HGTAPKYAGQ
360 370 380 390 400
DKVNPGSLIL SAEMMLRHMG WTEAADLIIR GMEGSIEAKT VTYDFERLMP
410
NATLLRCSEF GDALIRHME
Length:419
Mass (Da):46,291
Last modified:November 30, 2010 - v1
Checksum:iF7F69599C3EA32C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929140 Genomic DNA. Translation: CBL45150.1.
RefSeqiWP_013261644.1. NC_014366.1.
YP_003810802.1. NC_014366.1.

Genome annotation databases

EnsemblBacteriaiCBL45150; CBL45150; HDN1F_15670.
KEGGigpb:HDN1F_15670.
PATRICi42346105. VBIGamPro61291_1703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929140 Genomic DNA. Translation: CBL45150.1.
RefSeqiWP_013261644.1. NC_014366.1.
YP_003810802.1. NC_014366.1.

3D structure databases

ProteinModelPortaliE1VK08.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBL45150; CBL45150; HDN1F_15670.
KEGGigpb:HDN1F_15670.
PATRICi42346105. VBIGamPro61291_1703.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Enzyme and pathway databases

BioCyciGPRO83406:GIWA-1605-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alkane degradation by a new type of denitrifying bacterium with possible involvement of the electron acceptor in substrate activation."
    Widdel F., Rabus R., Grundmann O., Werner I., Schreiber F., Ehrenreich P., Behrends A., Wilkes H., Kube M., Reinhardt R., Zedelius J.
    Environ. Microbiol. 0:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiE1VK08_9GAMM
AccessioniPrimary (citable) accession number: E1VK08
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: April 1, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.