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E1VK08

- E1VK08_9GAMM

UniProt

E1VK08 - E1VK08_9GAMM

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, HDN1F_15670
Organism
gamma proteobacterium HdN1
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciGPRO83406:GIWA-1605-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:HDN1F_15670Imported
Organismigamma proteobacterium HdN1Imported
Taxonomic identifieri83406 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteria
ProteomesiUP000002677: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1VK08.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1VK08-1 [UniParc]FASTAAdd to Basket

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MGYQKIKVPA DGDKITVNAD LSLNVPNYPV IPFIEGDGIG VDITPVMLKV    50
VNAAVEKAYG TKRAISWMEV YCGEKATKVY GPDVWLPEET LDVLREYIVS 100
IKGPLTTPVG GGIRSLNVAL RQELDLYVCQ RPVRWFKGVP SPVTSPHKTD 150
MVIFRENSED IYAGIEWKAD SPEAIKIIKF LQEEMGVKKI RFTEHCGIGI 200
KPVSKEGTQR LVRKAIQYAI DNDEPSVTFV HKGNIMKYTE GAFKEWGYEL 250
AQERFGAELL DGGPWMTMKN PKTGRDIIIK DVIADAFLQQ ILMRPEEYSI 300
IATLNLNGDY ISDALAAEVG GIGIAPGANI GGSVAMFEAT HGTAPKYAGQ 350
DKVNPGSLIL SAEMMLRHMG WTEAADLIIR GMEGSIEAKT VTYDFERLMP 400
NATLLRCSEF GDALIRHME 419
Length:419
Mass (Da):46,291
Last modified:November 30, 2010 - v1
Checksum:iF7F69599C3EA32C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP929140 Genomic DNA. Translation: CBL45150.1.
RefSeqiWP_013261644.1. NC_014366.1.
YP_003810802.1. NC_014366.1.

Genome annotation databases

EnsemblBacteriaiCBL45150; CBL45150; HDN1F_15670.
GeneIDi9700866.
KEGGigpb:HDN1F_15670.
PATRICi42346105. VBIGamPro61291_1703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP929140 Genomic DNA. Translation: CBL45150.1 .
RefSeqi WP_013261644.1. NC_014366.1.
YP_003810802.1. NC_014366.1.

3D structure databases

ProteinModelPortali E1VK08.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBL45150 ; CBL45150 ; HDN1F_15670 .
GeneIDi 9700866.
KEGGi gpb:HDN1F_15670.
PATRICi 42346105. VBIGamPro61291_1703.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci GPRO83406:GIWA-1605-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alkane degradation by a new type of denitrifying bacterium with possible involvement of the electron acceptor in substrate activation."
    Widdel F., Rabus R., Grundmann O., Werner I., Schreiber F., Ehrenreich P., Behrends A., Wilkes H., Kube M., Reinhardt R., Zedelius J.
    Environ. Microbiol. 0:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiE1VK08_9GAMM
AccessioniPrimary (citable) accession number: E1VK08
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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