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E1V7Q5

- E1V7Q5_HALED

UniProt

E1V7Q5 - E1V7Q5_HALED

Protein

Alanine racemase

Gene

dadX

Organism
Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei131 – 1311SubstrateUniRule annotation
    Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHELO768066:GJEE-2677-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:dadXImported
    Ordered Locus Names:HELO_3609Imported
    OrganismiHalomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)Imported
    Taxonomic identifieri768066 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeHalomonas
    ProteomesiUP000008707: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE1V7Q5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031446.
    KOiK01775.
    OMAiYGHGLER.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1V7Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPLRADID LDALCHNYRL ARDLAPTSRS LAVLKADAYG HGLVPCARAL    50
    EGLAPAFAVA CLEEAEALRE GGITAPIVLL EGIFSADELA RVEALKLGTV 100
    VHSDWQVEAL LSHRPAEPIP TWVKVDSGMH RLGFAPERAA SVWARLSAAP 150
    AQACDLHLMS HFATADHADT AYFEHQMRTL NALAETLNAP TCLANSPATL 200
    ARPESHGAWN RPGVMLYGSD PLEASNSASR ELEPVMTLRS QLIAVRDLDE 250
    GEPVGYGGRW RAPRPSRIGV VACGYGDGYD RHAIDGTPAL VAGRRTTLVG 300
    KVSMDMLTVD LTDIPEADIG SEVVLWGRAA NGEVLSVDEV ARHCDTISYT 350
    LLTGVLPRVP RRYHSG 366
    Length:366
    Mass (Da):39,342
    Last modified:November 30, 2010 - v1
    Checksum:i65C9103CEFFC0470
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN869568 Genomic DNA. Translation: CBV43493.1.
    RefSeqiWP_013333365.1. NC_014532.1.
    YP_003898678.1. NC_014532.1.

    Genome annotation databases

    EnsemblBacteriaiCBV43493; CBV43493; HELO_3609.
    GeneIDi9747860.
    KEGGihel:HELO_3609.
    PATRICi42356781. VBIHalElo161731_2804.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN869568 Genomic DNA. Translation: CBV43493.1 .
    RefSeqi WP_013333365.1. NC_014532.1.
    YP_003898678.1. NC_014532.1.

    3D structure databases

    ProteinModelPortali E1V7Q5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBV43493 ; CBV43493 ; HELO_3609 .
    GeneIDi 9747860.
    KEGGi hel:HELO_3609.
    PATRICi 42356781. VBIHalElo161731_2804.

    Phylogenomic databases

    HOGENOMi HOG000031446.
    KOi K01775.
    OMAi YGHGLER.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci HELO768066:GJEE-2677-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581(T)."
      Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G., Seitz H., Rampp M., Schuster S.C., Klenk H.P., Pfeiffer F., Oesterhelt D., Kunte H.J.
      Environ. Microbiol. 13:1973-1994(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9Imported.

    Entry informationi

    Entry nameiE1V7Q5_HALED
    AccessioniPrimary (citable) accession number: E1V7Q5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3