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Protein

Alanine racemase

Gene

alr

Organism
Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Active sitei256Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei304Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HELO_3609Imported
OrganismiHalomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)Imported
Taxonomic identifieri768066 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeHalomonas
Proteomesi
  • UP000008707 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi768066.HELO_3609.

Structurei

3D structure databases

ProteinModelPortaliE1V7Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 364Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031446.
KOiK01775.
OMAiWRGPILL.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

E1V7Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLRADID LDALCHNYRL ARDLAPTSRS LAVLKADAYG HGLVPCARAL
60 70 80 90 100
EGLAPAFAVA CLEEAEALRE GGITAPIVLL EGIFSADELA RVEALKLGTV
110 120 130 140 150
VHSDWQVEAL LSHRPAEPIP TWVKVDSGMH RLGFAPERAA SVWARLSAAP
160 170 180 190 200
AQACDLHLMS HFATADHADT AYFEHQMRTL NALAETLNAP TCLANSPATL
210 220 230 240 250
ARPESHGAWN RPGVMLYGSD PLEASNSASR ELEPVMTLRS QLIAVRDLDE
260 270 280 290 300
GEPVGYGGRW RAPRPSRIGV VACGYGDGYD RHAIDGTPAL VAGRRTTLVG
310 320 330 340 350
KVSMDMLTVD LTDIPEADIG SEVVLWGRAA NGEVLSVDEV ARHCDTISYT
360
LLTGVLPRVP RRYHSG
Length:366
Mass (Da):39,342
Last modified:November 30, 2010 - v1
Checksum:i65C9103CEFFC0470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN869568 Genomic DNA. Translation: CBV43493.1.

Genome annotation databases

EnsemblBacteriaiCBV43493; CBV43493; HELO_3609.
KEGGihel:HELO_3609.

Similar proteinsi

Entry informationi

Entry nameiE1V7Q5_HALED
AccessioniPrimary (citable) accession number: E1V7Q5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 27, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported