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Protein

Alanine racemase

Gene

alrA

Organism
Bacillus amyloliquefaciens (strain ATCC 23350 / DSM 7 / BCRC 11601 / NBRC 15535 / NRRL B-14393)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei137 – 1371SubstrateUniRule annotation
Active sitei266 – 2661Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei313 – 3131Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBAMY692420:GHU2-490-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrAImported
Synonyms:alr2Imported
Ordered Locus Names:BAMF_0441Imported
OrganismiBacillus amyloliquefaciens (strain ATCC 23350 / DSM 7 / BCRC 11601 / NBRC 15535 / NRRL B-14393)Imported
Taxonomic identifieri692420 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000006562 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1ULL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1ULL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTASFYRDT WAEINLSAIK ENITHMKKHI GENVHLMAVV KANAYGHGDL
60 70 80 90 100
EVGKAALEAG ASCLAVAILD EAISLRKRGI TAPILVLGAV PPEYVQAAAE
110 120 130 140 150
YDVTLTGYSV EWLQEAARHL GSETVPFHLK VDTGMNRLGV KTEEEIQSVL
160 170 180 190 200
KILSQNPGLV CKGVFTHFAT ADEKNRDYFL FQFERFKKLI APLPLKELMV
210 220 230 240 250
HCANSAAGLR LKKGFFNAVR FGISMYGLRP SADIQNEIPF QLKPAFTLHS
260 270 280 290 300
VLSHVKKIRK GESVSYGATY TAEKDQWIGT VPIGYADGWL RKLSGTAVLI
310 320 330 340 350
DGKRMNIAGR ICMDQLMVEL DQSYPPGTKV TLIGSQKEET ITMDEIAGRL
360 370 380
ETINYEIPCT ISSRVPRMFL ENESIMEVRN PLLQENTSK
Length:389
Mass (Da):43,147
Last modified:November 30, 2010 - v1
Checksum:i0299C6A6DC25C5C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN597644 Genomic DNA. Translation: CBI41567.1.
RefSeqiYP_003919037.1. NC_014551.1.

Genome annotation databases

EnsemblBacteriaiCBI41567; CBI41567; BAMF_0441.
KEGGibao:BAMF_0441.
PATRICi42469716. VBIBacAmy172706_0474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN597644 Genomic DNA. Translation: CBI41567.1.
RefSeqiYP_003919037.1. NC_014551.1.

3D structure databases

ProteinModelPortaliE1ULL7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBI41567; CBI41567; BAMF_0441.
KEGGibao:BAMF_0441.
PATRICi42469716. VBIBacAmy172706_0474.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBAMY692420:GHU2-490-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Relationship of Bacillus amyloliquefaciens clades associated with strains DSM7T and FZB42: a proposal for Bacillus amyloliquefaciens subsp. amyloliquefaciens subsp. nov. and Bacillus amyloliquefaciens subsp. plantarum subsp. nov. based on their discriminating complete genome sequences."
    Borriss R., Chen X., Rueckert C., Blom J., Becker A., Baumgarth B., Fan B., Pukall R., Schumann P., Sproer C., Junge H., Vater J., Puhler A., Klenk H.P.
    Int. J. Syst. Evol. Microbiol. 0:0-0(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM7.
  2. "Genome sequence of B. amyloliquefaciens type strain DSM7(T) reveals differences to plant-associated B. amyloliquefaciens FZB42."
    Ruckert C., Blom J., Chen X., Reva O., Borriss R.
    J. Biotechnol. 155:78-85(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23350 / DSM 7 / BCRC 11601 / NBRC 15535 / NRRL B-14393Imported.

Entry informationi

Entry nameiE1ULL7_BACAS
AccessioniPrimary (citable) accession number: E1ULL7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: April 1, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.