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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Listeria monocytogenes serotype 4a (strain L99)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciLMON563174:GLFX-2497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:lmo4a_2435Imported
OrganismiListeria monocytogenes serotype 4a (strain L99)Imported
Taxonomic identifieri563174 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000008708: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

E1UAV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSENDKRK HESYRIPLFG SEEESTSIPK YVLKKEPMEP RIAYQLVKDQ
60 70 80 90 100
LMDEGNARQN LATFCQTYME KEAEILMAET LEKNAIDKSE YPQTAELENR
110 120 130 140 150
CVNILADLWN APKEMAYLGT STVGSSEACM LGGLAMKFRW RNHAEKRGLD
160 170 180 190 200
IQAKRPNLII SSGYQVCWEK FCVYWDVDMR VVPMDKEHLS IDVDKVFDLV
210 220 230 240 250
DDYTIGIVGI LGITYTGKFD DIALLNEKVE AYNEANEHQL VIHIDGASGA
260 270 280 290 300
MFTPFVNPEL PWDFRLKNVV SINTSGHKYG LVYPGVGWIL WKDKEYLPKE
310 320 330 340 350
LIFEVSYLGG SMPTMAINFS RSASQIIGQY YNFLRYGFEG YREIHEKTKK
360 370 380 390 400
TALYLAKTVE KSGYFEIIND GANLPIVCYK MKEGLDVEWT LYDLADQLLM
410 420 430 440 450
KGWQVPAYPL PADLSDTIIQ RFVCRADLGY NVAEEFAADF ADALHNLEHA
460
RVLYHDKERN DSYGFTH
Length:467
Mass (Da):53,596
Last modified:November 30, 2010 - v1
Checksum:i209CAAF0D50BFAF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211688 Genomic DNA. Translation: CAR85139.1.
RefSeqiYP_005927428.1. NC_017529.1.

Genome annotation databases

EnsemblBacteriaiCAR85139; CAR85139; lmo4a_2435.
GeneIDi12517737.
KEGGilml:lmo4a_2435.
PATRICi43111065. VBILisMon174077_2508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211688 Genomic DNA. Translation: CAR85139.1.
RefSeqiYP_005927428.1. NC_017529.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR85139; CAR85139; lmo4a_2435.
GeneIDi12517737.
KEGGilml:lmo4a_2435.
PATRICi43111065. VBILisMon174077_2508.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.

Enzyme and pathway databases

BioCyciLMON563174:GLFX-2497-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L99Imported.

Entry informationi

Entry nameiE1UAV4_LISML
AccessioniPrimary (citable) accession number: E1UAV4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.