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E1T294

- E1T294_THESX

UniProt

E1T294 - E1T294_THESX

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Protein

Thymidine kinase

Gene
tdk, Thet_0126
Organism
Thermoanaerobacter sp. (strain X513)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptor By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi149 – 1491Zinc By similarityUniRule annotation
Metal bindingi184 – 1841Zinc By similarityUniRule annotation
Metal bindingi187 – 1871Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATP By similarityUniRule annotation
Nucleotide bindingi89 – 924ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTSP573062:GHR1-140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Thet_0126Imported
OrganismiThermoanaerobacter sp. (strain X513)Imported
Taxonomic identifieri573062 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002731: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE1T294.
SMRiE1T294. Positions 3-192.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1T294-1 [UniParc]FASTAAdd to Basket

« Hide

MIYGSLDHGF IEVIVGPMFS GKSEELIRRI KRAQIAKQKV QVFKPAIDDR    50
YSIDKVVSHN GTNINAISVV KAFEIIELLE EDTEVIAIDE IQFFDHSIVD 100
VVREIADLGK RVICAGLDMD FRGEPFGPTP DVMAIAESVD KLTAICVKCG 150
NPATRTQRLI NGKPAKYDDP IILVGAHETY EARCRKCHEV PRT 193
Length:193
Mass (Da):21,525
Last modified:November 30, 2010 - v1
Checksum:iC3A1EB55D37A84D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002210 Genomic DNA. Translation: ADN53794.1.
RefSeqiYP_003903085.1. NC_014538.1.

Genome annotation databases

EnsemblBacteriaiADN53794; ADN53794; Thet_0126.
GeneIDi9759871.
KEGGithx:Thet_0126.
PATRICi42444285. VBITheSp37765_0135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002210 Genomic DNA. Translation: ADN53794.1 .
RefSeqi YP_003903085.1. NC_014538.1.

3D structure databases

ProteinModelPortali E1T294.
SMRi E1T294. Positions 3-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN53794 ; ADN53794 ; Thet_0126 .
GeneIDi 9759871.
KEGGi thx:Thet_0126.
PATRICi 42444285. VBITheSp37765_0135.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.

Enzyme and pathway databases

BioCyci TSP573062:GHR1-140-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X513Imported.

Entry informationi

Entry nameiE1T294_THESX
AccessioniPrimary (citable) accession number: E1T294
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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