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E1S9A2 (E1S9A2_HELP9) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS009006

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site371Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2711Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1351Substrate By similarity HAMAP-Rule MF_01201
Binding site3191Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue371N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
E1S9A2 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: BBBC82A5E2135922

FASTA37741,806
        10         20         30         40         50         60 
MLKRASFVEV NTASLRHNFN AVKSIVPKDA CVMAVVKANA YGAGALKASE IFLQEGANYL 

        70         80         90        100        110        120 
GVATLDEALE LRSHFSKTPI LILGYNPNAN ASMLIDNDLS AMVFSLEQAE VFSQMALKSQ 

       130        140        150        160        170        180 
KRLKIHLKID TGMHRLGLEP TFKSIEIVKK IRALKGLEVE GIFTHLSNAD ANIKTHAKNQ 

       190        200        210        220        230        240 
MKAFNAFLEQ LLNQKIEFKY RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNEMK 

       250        260        270        280        290        300 
ESSQTILKNV ISLKARIVQI KRVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLVRALGN 

       310        320        330        340        350        360 
RIQVAINNQL APLIGKVCMD QCFVKLNGIE AKEGDEVILF GDKSAKANDA SEIAALLNTI 

       370 
PYETISTLSK RLERVYI 

« Hide

References

[1]"Genome of Helicobacter pylori strain 908."
Devi S.H., Taylor T.D., Avasthi T.S., Kondo S., Suzuki Y., Megraud F., Ahmed N.
J. Bacteriol. 192:6488-6489(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 908 EMBL ADN80082.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002184 Genomic DNA. Translation: ADN80082.1.
RefSeqYP_005765456.1. NC_017357.1.

3D structure databases

ProteinModelPortalE1S9A2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADN80082; ADN80082; hp908_0956.
GeneID12343879.
KEGGhpi:hp908_0956.
PATRIC43059586. VBIHelPyl166603_0966.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.
OMAINNQLAP.

Enzyme and pathway databases

BioCycHPYL869727:GLE7-972-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE1S9A2_HELP9
AccessionPrimary (citable) accession number: E1S9A2
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)