E1RYA5 (E1RYA5_ECOUM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
Short name=PEPC HAMAP-Rule MF_00595
Short name=PEPCase HAMAP-Rule MF_00595
EC=4.1.1.31 HAMAP-Rule MF_00595

Gene names

Name:	ppc HAMAP-Rule MF_00595
Ordered Locus Names:	UM146_20035 EMBL ADN73337.1

Organism

Escherichia coli (strain UM146) [Complete proteome] [HAMAP] EMBL ADN73337.1

Taxonomic identifier

869729 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	883 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595 SAAS SAAS022805
Catalytic activity	Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595 SAAS SAAS021135
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00595 SAAS SAAS021135
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00595
Sequence similarities	Belongs to the PEPCase type 1 family. HAMAP-Rule MF_00595

Ontologies

Keywords
Biological process	Carbon dioxide fixation HAMAP-Rule MF_00595 SAAS SAAS021135
Ligand	Magnesium HAMAP-Rule MF_00595 SAAS SAAS021135 Pyruvate EMBL ADN73337.1
Molecular function	Lyase HAMAP-Rule MF_00595 SAAS SAAS021135 EMBL ADN73337.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbon fixation Inferred from electronic annotation. Source: HAMAP oxaloacetate metabolic process Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoenolpyruvate carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	138	1	By similarity HAMAP-Rule MF_00595
	Active site	546	1	By similarity HAMAP-Rule MF_00595

Sequences

	Sequence		Length	Mass (Da)
	E1RYA5 [UniParc]. Last modified November 30, 2010. Version 1. Checksum: 850A8E76CF0507B7	FASTA	883	99,090
	10 20 30 40 50 60 MNEQYSALRS NVSMLGKVLG ETIKDALGEH ILERVETIRK LSKSSRAGND ANRQELLTTL 70 80 90 100 110 120 QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPKGEAASN PEVIARTLRK LKNQPELSED 130 140 150 160 170 180 TIKKAVESLS LELVLTAHPT EITRRTLIHK MVEVNACLKQ LDNKDIADYE HNQLMRRLRQ 190 200 210 220 230 240 LIAQSWHTDE IRKLRPSPVD EAKWGFAVVE NSLWQGVPNY LRELNEQLEE NLGYKLPVEF 250 260 270 280 290 300 VPVRFTSWMG GDRDGNPNVT ADITRHVLLL SRWKATDLFL KDIQVLVSEL SMVEATPELL 310 320 330 340 350 360 ALVGEEGAAE PYRYLMKNLR SRLMATQAWL EARLKGEELP KPEGLLTQNE ELWEPLYACY 370 380 390 400 410 420 QSLQACGMGI IANGDLLDTL RRVKCFGVPL VRIDIRQEST RHTEALGELT RYLGIGDYES 430 440 450 460 470 480 WSEADKQAFL IRELNSKRPL LPRNWQPSAE TREVLDTCQV IAEAPQGSIA AYVISMAKTP 490 500 510 520 530 540 SDVLAVHLLL KEAGIGFAMP VAPLFETLDD LNNANDVMTQ LLNIDWYRGL IQGKQMVMIG 550 560 570 580 590 600 YSDSAKDAGV MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP 610 620 630 640 650 660 PGSLKGGLRV TEQGEMIRFK YGLPEITVSS LSLYTGAILE ANLLPPPEPK ESWRRIMDEL 670 680 690 700 710 720 SVISCDVYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP AKRRPTGGVE SLRAIPWIFA 730 740 750 760 770 780 WTQNRLMLPA WLGAGTALQK VVEDGKQNEL EAMCRDWPFF STRLGMLEMV FAKADLWLAE 790 800 810 820 830 840 YYDQRLVDKA LWPLGKELRN LQEEDIKVVL AIANDSHLMA DLPWIAESIQ LRNIYTDPLN 850 860 870 880 VLQAELLHRS RQAEKEGQEP DPRVEQALMV TIAGIAAGMR NTG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from ileal Crohn's disease biopsy tissue." Krause D.O., Little A.C., Dowd S.E., Bernstein C.N. J. Bacteriol. 193:583-583(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UM146 EMBL ADN73337.1.
[2]	"Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from ileal Crohn's disease biopsy tissue." Krause D.O., Little A.C., Dowd S.E., Bernstein C.N. Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: UM146.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002167 Genomic DNA. Translation: ADN73337.1.
RefSeq	YP_006112849.1. NC_017632.1.
3D structure databases
ProteinModelPortal	E1RYA5.
SMR	E1RYA5. Positions 4-883.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADN73337; ADN73337; UM146_20035.
GeneID	12702509.
KEGG	elu:UM146_20035.
PATRIC	42975026. VBIEscCol167775_4305.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000238648.
KO	K01595.
Enzyme and pathway databases
BioCyc	ECOL869729:GI9Z-3998-MONOMER.
Family and domain databases
HAMAP	MF_00595. PEPcase_type1.
InterPro	IPR021135. PEP_COase. IPR018129. PEP_COase_AS. IPR022805. PEP_COase_bac/pln-type. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. [Graphical view]
Pfam	PF00311. PEPcase. 1 hit. [Graphical view]
PRINTS	PR00150. PEPCARBXLASE.
SUPFAM	SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
PROSITE	PS00781. PEPCASE_1. 1 hit. PS00393. PEPCASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E1RYA5_ECOUM

Accession

Primary (citable) accession number: E1RYA5

Entry history

Integrated into UniProtKB/TrEMBL:	November 30, 2010
Last sequence update:	November 30, 2010
Last modified:	May 29, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)