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Protein

Alanine racemase

Gene

alr

Organism
Xylella fastidiosa (strain GB514)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Active sitei254 – 2541Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciXFAS788929:GLMT-669-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:XFLM_03555Imported
OrganismiXylella fastidiosa (strain GB514)Imported
Taxonomic identifieri788929 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000008704: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1RLV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiDAGTISY.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1RLV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPAHAVIDL DALRHNYRFA RRLGGGKALA VVKADAYGHG AVRCAQALEA
60 70 80 90 100
EVDGFAVACI EEALELRQAG IQAPILLLEG FFEVEELELI AKHNLWTVIA
110 120 130 140 150
SSWQVRALAA FHSPSPIGVW LKLDSGMHRL GLEPKEFRDA WMSLHSLPQV
160 170 180 190 200
GEVVLMTHLA RADELDNPRT NEQASVFAHA SQGMVAPASV CNSSGLLGWA
210 220 230 240 250
GLYSDWGRPG LMLYGVNPIS QESTSLSGPL RPVMMVYSKL IAVRELPAGE
260 270 280 290 300
PVGYGASFVT ERPTRVGVVA MGYADGYPYF AVNGTPLLVD GRVCPLIGRV
310 320 330 340 350
SMDMLTVDLT DHPQADVGSQ VQLWGVQPGV AELAAHCNLS AYQLLCGLKR
360
VRRYYLGEMG AV
Length:362
Mass (Da):39,156
Last modified:November 30, 2010 - v1
Checksum:iDC850C59FD1564ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002165 Genomic DNA. Translation: ADN62689.1.
RefSeqiYP_006000055.1. NC_017562.1.

Genome annotation databases

EnsemblBacteriaiADN62689; ADN62689; XFLM_03555.
GeneIDi12588530.
KEGGixff:XFLM_03555.
PATRICi43284796. VBIXylFas171671_0863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002165 Genomic DNA. Translation: ADN62689.1.
RefSeqiYP_006000055.1. NC_017562.1.

3D structure databases

ProteinModelPortaliE1RLV6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADN62689; ADN62689; XFLM_03555.
GeneIDi12588530.
KEGGixff:XFLM_03555.
PATRICi43284796. VBIXylFas171671_0863.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiDAGTISY.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciXFAS788929:GLMT-669-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Unraveling the first Xylella fastidiosa subsp. fastidiosa genome from Texas."
    Dowd S.E., Morano L., Bextine B., Lara A., Koirala M., Schreiber H.L., Ojeda M.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB514Imported.

Entry informationi

Entry nameiE1RLV6_XYLFG
AccessioniPrimary (citable) accession number: E1RLV6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.