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E1RDW0 (E1RDW0_METP4) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase HAMAP-Rule MF_00407
EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Mpet_2400
OrganismMethanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847) [Complete proteome] [HAMAP] EMBL ADN37147.1
Taxonomic identifier679926 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoplanus ›

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2461N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2441ATP By similarity HAMAP-Rule MF_00407
Binding site2511ATP By similarity HAMAP-Rule MF_00407
Binding site2661ATP By similarity HAMAP-Rule MF_00407
Binding site2951ATP By similarity HAMAP-Rule MF_00407
Binding site3351ATP By similarity HAMAP-Rule MF_00407
Binding site4061ATP By similarity HAMAP-Rule MF_00407
Binding site4121ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
E1RDW0 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 2323FDABED1BE1B8

FASTA54861,463
        10         20         30         40         50         60 
MQFSEFSEIC GQLEKISGRL DTIDMIASHL PGLDDEELPI FIRFLMGRIF PDWSQDKIGI 

        70         80         90        100        110        120 
GPNLVFESVA YVAGNDRSKV VREINKQGDV GTAVENILSK KEQTSFFSEN PDLRDVYSDF 

       130        140        150        160        170        180 
AYLSSIEGNR SQKEKLKVIR KLFANAGGAE GKYLSRLILG ELRIGIGEGN IRDAIAKAFD 

       190        200        210        220        230        240 
VPTESVEHAY QAANDLGEIA VIAKKGVDEL RAVRISLFRP VKMMLAKQGT IAEMVEEQGA 

       250        260        270        280        290        300 
IAAEYKYDGT RFQFHKSGDK CRIYSRKLEE VTTAIPDIVD ILVKTTGHDV ILDGEVIAVD 

       310        320        330        340        350        360 
GNGNPMPFQH VLKRFRRKHD IASHIENIRL VPNIFDILYL DGETLIDKPF EERRKILVEN 

       370        380        390        400        410        420 
VSLHVAPQIV SDDIITIEAF YREALDAGHE GIMIKSLKSA YTPGQRVRQW IKIKPSVDTI 

       430        440        450        460        470        480 
DLAVVGAEWG EGKRAHLFGS FILACQDESG RLLRISKVAT GFSDEALAGV YDLLKDTEIS 

       490        500        510        520        530        540 
ESGKVVSFEP EVVFEVGYAE IQKSTNYEAG YALRFPRFIR FRDDKGIDEI ETISSIEDRF 


RAQSEKIR

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002117 Genomic DNA. Translation: ADN37147.1.
RefSeqYP_003895585.1. NC_014507.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADN37147; ADN37147; Mpet_2400.
GeneID9744892.
KEGGmpi:Mpet_2400.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.
OMAARVQVHK.

Enzyme and pathway databases

BioCycMPET679926:GHOF-2455-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE1RDW0_METP4
AccessionPrimary (citable) accession number: E1RDW0
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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