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E1RDW0

- E1RDW0_METP4

UniProt

E1RDW0 - E1RDW0_METP4

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Protein

DNA ligase

Gene
lig, Mpet_2400
Organism
Methanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATP By similarityUniRule annotation
Active sitei246 – 2461N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei251 – 2511ATP By similarityUniRule annotation
Binding sitei266 – 2661ATP By similarityUniRule annotation
Binding sitei295 – 2951ATP By similarityUniRule annotation
Binding sitei335 – 3351ATP By similarityUniRule annotation
Binding sitei406 – 4061ATP By similarityUniRule annotation
Binding sitei412 – 4121ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPET679926:GHOF-2455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mpet_2400Imported
OrganismiMethanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847)Imported
Taxonomic identifieri679926 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoplanus
ProteomesiUP000006565: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1RDW0-1 [UniParc]FASTAAdd to Basket

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MQFSEFSEIC GQLEKISGRL DTIDMIASHL PGLDDEELPI FIRFLMGRIF    50
PDWSQDKIGI GPNLVFESVA YVAGNDRSKV VREINKQGDV GTAVENILSK 100
KEQTSFFSEN PDLRDVYSDF AYLSSIEGNR SQKEKLKVIR KLFANAGGAE 150
GKYLSRLILG ELRIGIGEGN IRDAIAKAFD VPTESVEHAY QAANDLGEIA 200
VIAKKGVDEL RAVRISLFRP VKMMLAKQGT IAEMVEEQGA IAAEYKYDGT 250
RFQFHKSGDK CRIYSRKLEE VTTAIPDIVD ILVKTTGHDV ILDGEVIAVD 300
GNGNPMPFQH VLKRFRRKHD IASHIENIRL VPNIFDILYL DGETLIDKPF 350
EERRKILVEN VSLHVAPQIV SDDIITIEAF YREALDAGHE GIMIKSLKSA 400
YTPGQRVRQW IKIKPSVDTI DLAVVGAEWG EGKRAHLFGS FILACQDESG 450
RLLRISKVAT GFSDEALAGV YDLLKDTEIS ESGKVVSFEP EVVFEVGYAE 500
IQKSTNYEAG YALRFPRFIR FRDDKGIDEI ETISSIEDRF RAQSEKIR 548
Length:548
Mass (Da):61,463
Last modified:November 30, 2010 - v1
Checksum:i2323FDABED1BE1B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002117 Genomic DNA. Translation: ADN37147.1.
RefSeqiYP_003895585.1. NC_014507.1.

Genome annotation databases

EnsemblBacteriaiADN37147; ADN37147; Mpet_2400.
GeneIDi9744892.
KEGGimpi:Mpet_2400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002117 Genomic DNA. Translation: ADN37147.1 .
RefSeqi YP_003895585.1. NC_014507.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN37147 ; ADN37147 ; Mpet_2400 .
GeneIDi 9744892.
KEGGi mpi:Mpet_2400.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MPET679926:GHOF-2455-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11571 / OCM 486 / SEBR 4847.

Entry informationi

Entry nameiE1RDW0_METP4
AccessioniPrimary (citable) accession number: E1RDW0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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