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E1RDW0

- E1RDW0_METP4

UniProt

E1RDW0 - E1RDW0_METP4

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Protein

DNA ligase

Gene

lig

Organism
Methanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATPUniRule annotation
Active sitei246 – 2461N6-AMP-lysine intermediateUniRule annotation
Binding sitei251 – 2511ATPUniRule annotation
Binding sitei266 – 2661ATPUniRule annotation
Binding sitei295 – 2951ATPUniRule annotation
Binding sitei335 – 3351ATPUniRule annotation
Binding sitei406 – 4061ATPUniRule annotation
Binding sitei412 – 4121ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPET679926:GHOF-2455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mpet_2400Imported
OrganismiMethanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847)Imported
Taxonomic identifieri679926 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoplanus
ProteomesiUP000006565: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1RDW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFSEFSEIC GQLEKISGRL DTIDMIASHL PGLDDEELPI FIRFLMGRIF
60 70 80 90 100
PDWSQDKIGI GPNLVFESVA YVAGNDRSKV VREINKQGDV GTAVENILSK
110 120 130 140 150
KEQTSFFSEN PDLRDVYSDF AYLSSIEGNR SQKEKLKVIR KLFANAGGAE
160 170 180 190 200
GKYLSRLILG ELRIGIGEGN IRDAIAKAFD VPTESVEHAY QAANDLGEIA
210 220 230 240 250
VIAKKGVDEL RAVRISLFRP VKMMLAKQGT IAEMVEEQGA IAAEYKYDGT
260 270 280 290 300
RFQFHKSGDK CRIYSRKLEE VTTAIPDIVD ILVKTTGHDV ILDGEVIAVD
310 320 330 340 350
GNGNPMPFQH VLKRFRRKHD IASHIENIRL VPNIFDILYL DGETLIDKPF
360 370 380 390 400
EERRKILVEN VSLHVAPQIV SDDIITIEAF YREALDAGHE GIMIKSLKSA
410 420 430 440 450
YTPGQRVRQW IKIKPSVDTI DLAVVGAEWG EGKRAHLFGS FILACQDESG
460 470 480 490 500
RLLRISKVAT GFSDEALAGV YDLLKDTEIS ESGKVVSFEP EVVFEVGYAE
510 520 530 540
IQKSTNYEAG YALRFPRFIR FRDDKGIDEI ETISSIEDRF RAQSEKIR
Length:548
Mass (Da):61,463
Last modified:November 30, 2010 - v1
Checksum:i2323FDABED1BE1B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002117 Genomic DNA. Translation: ADN37147.1.
RefSeqiWP_013330324.1. NC_014507.1.
YP_003895585.1. NC_014507.1.

Genome annotation databases

EnsemblBacteriaiADN37147; ADN37147; Mpet_2400.
GeneIDi9744892.
KEGGimpi:Mpet_2400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002117 Genomic DNA. Translation: ADN37147.1 .
RefSeqi WP_013330324.1. NC_014507.1.
YP_003895585.1. NC_014507.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN37147 ; ADN37147 ; Mpet_2400 .
GeneIDi 9744892.
KEGGi mpi:Mpet_2400.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MPET679926:GHOF-2455-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11571 / OCM 486 / SEBR 4847Imported.

Entry informationi

Entry nameiE1RDW0_METP4
AccessioniPrimary (citable) accession number: E1RDW0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3