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Protein

DNA ligase

Gene

lig

Organism
Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847) (Methanoplanus petrolearius)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATPUniRule annotation
Active sitei246 – 2461N6-AMP-lysine intermediateUniRule annotation
Binding sitei251 – 2511ATPUniRule annotation
Binding sitei266 – 2661ATPUniRule annotation
Binding sitei295 – 2951ATPUniRule annotation
Binding sitei335 – 3351ATPUniRule annotation
Binding sitei406 – 4061ATPUniRule annotation
Binding sitei412 – 4121ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPET679926:GHOF-2455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mpet_2400Imported
OrganismiMethanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847) (Methanoplanus petrolearius)Imported
Taxonomic identifieri679926 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanolacinia
ProteomesiUP000006565 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi679926.Mpet_2400.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1RDW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSEFSEIC GQLEKISGRL DTIDMIASHL PGLDDEELPI FIRFLMGRIF
60 70 80 90 100
PDWSQDKIGI GPNLVFESVA YVAGNDRSKV VREINKQGDV GTAVENILSK
110 120 130 140 150
KEQTSFFSEN PDLRDVYSDF AYLSSIEGNR SQKEKLKVIR KLFANAGGAE
160 170 180 190 200
GKYLSRLILG ELRIGIGEGN IRDAIAKAFD VPTESVEHAY QAANDLGEIA
210 220 230 240 250
VIAKKGVDEL RAVRISLFRP VKMMLAKQGT IAEMVEEQGA IAAEYKYDGT
260 270 280 290 300
RFQFHKSGDK CRIYSRKLEE VTTAIPDIVD ILVKTTGHDV ILDGEVIAVD
310 320 330 340 350
GNGNPMPFQH VLKRFRRKHD IASHIENIRL VPNIFDILYL DGETLIDKPF
360 370 380 390 400
EERRKILVEN VSLHVAPQIV SDDIITIEAF YREALDAGHE GIMIKSLKSA
410 420 430 440 450
YTPGQRVRQW IKIKPSVDTI DLAVVGAEWG EGKRAHLFGS FILACQDESG
460 470 480 490 500
RLLRISKVAT GFSDEALAGV YDLLKDTEIS ESGKVVSFEP EVVFEVGYAE
510 520 530 540
IQKSTNYEAG YALRFPRFIR FRDDKGIDEI ETISSIEDRF RAQSEKIR
Length:548
Mass (Da):61,463
Last modified:November 30, 2010 - v1
Checksum:i2323FDABED1BE1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002117 Genomic DNA. Translation: ADN37147.1.
RefSeqiWP_013330324.1. NC_014507.1.
YP_003895585.1. NC_014507.1.

Genome annotation databases

EnsemblBacteriaiADN37147; ADN37147; Mpet_2400.
GeneIDi9744892.
KEGGimpi:Mpet_2400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002117 Genomic DNA. Translation: ADN37147.1.
RefSeqiWP_013330324.1. NC_014507.1.
YP_003895585.1. NC_014507.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi679926.Mpet_2400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADN37147; ADN37147; Mpet_2400.
GeneIDi9744892.
KEGGimpi:Mpet_2400.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciMPET679926:GHOF-2455-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11571 / OCM 486 / SEBR 4847Imported.

Entry informationi

Entry nameiE1RDW0_METP4
AccessioniPrimary (citable) accession number: E1RDW0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.