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E1RDW0

- E1RDW0_METP4

UniProt

E1RDW0 - E1RDW0_METP4

Protein

DNA ligase

Gene

lig

Organism
Methanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei244 – 2441ATPUniRule annotation
    Active sitei246 – 2461N6-AMP-lysine intermediateUniRule annotation
    Binding sitei251 – 2511ATPUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei295 – 2951ATPUniRule annotation
    Binding sitei335 – 3351ATPUniRule annotation
    Binding sitei406 – 4061ATPUniRule annotation
    Binding sitei412 – 4121ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPET679926:GHOF-2455-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mpet_2400Imported
    OrganismiMethanoplanus petrolearius (strain DSM 11571 / OCM 486 / SEBR 4847)Imported
    Taxonomic identifieri679926 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoplanus
    ProteomesiUP000006565: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1RDW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFSEFSEIC GQLEKISGRL DTIDMIASHL PGLDDEELPI FIRFLMGRIF    50
    PDWSQDKIGI GPNLVFESVA YVAGNDRSKV VREINKQGDV GTAVENILSK 100
    KEQTSFFSEN PDLRDVYSDF AYLSSIEGNR SQKEKLKVIR KLFANAGGAE 150
    GKYLSRLILG ELRIGIGEGN IRDAIAKAFD VPTESVEHAY QAANDLGEIA 200
    VIAKKGVDEL RAVRISLFRP VKMMLAKQGT IAEMVEEQGA IAAEYKYDGT 250
    RFQFHKSGDK CRIYSRKLEE VTTAIPDIVD ILVKTTGHDV ILDGEVIAVD 300
    GNGNPMPFQH VLKRFRRKHD IASHIENIRL VPNIFDILYL DGETLIDKPF 350
    EERRKILVEN VSLHVAPQIV SDDIITIEAF YREALDAGHE GIMIKSLKSA 400
    YTPGQRVRQW IKIKPSVDTI DLAVVGAEWG EGKRAHLFGS FILACQDESG 450
    RLLRISKVAT GFSDEALAGV YDLLKDTEIS ESGKVVSFEP EVVFEVGYAE 500
    IQKSTNYEAG YALRFPRFIR FRDDKGIDEI ETISSIEDRF RAQSEKIR 548
    Length:548
    Mass (Da):61,463
    Last modified:November 30, 2010 - v1
    Checksum:i2323FDABED1BE1B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002117 Genomic DNA. Translation: ADN37147.1.
    RefSeqiYP_003895585.1. NC_014507.1.

    Genome annotation databases

    EnsemblBacteriaiADN37147; ADN37147; Mpet_2400.
    GeneIDi9744892.
    KEGGimpi:Mpet_2400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002117 Genomic DNA. Translation: ADN37147.1 .
    RefSeqi YP_003895585.1. NC_014507.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADN37147 ; ADN37147 ; Mpet_2400 .
    GeneIDi 9744892.
    KEGGi mpi:Mpet_2400.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MPET679926:GHOF-2455-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11571 / OCM 486 / SEBR 4847Imported.

    Entry informationi

    Entry nameiE1RDW0_METP4
    AccessioniPrimary (citable) accession number: E1RDW0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3