Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

lig

Organism
Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847) (Methanoplanus petrolearius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1
Active sitei246N6-AMP-lysine intermediateUniRule annotation1
Binding sitei251ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei335ATPUniRule annotation1
Binding sitei406ATPUniRule annotation1
Binding sitei412ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPET679926:G1GN5-2425-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mpet_2400Imported
OrganismiMethanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847) (Methanoplanus petrolearius)Imported
Taxonomic identifieri679926 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanolacinia
Proteomesi
  • UP000006565 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi679926.Mpet_2400

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini334 – 447DNA_LIGASE_A3InterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

E1RDW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFSEFSEIC GQLEKISGRL DTIDMIASHL PGLDDEELPI FIRFLMGRIF
60 70 80 90 100
PDWSQDKIGI GPNLVFESVA YVAGNDRSKV VREINKQGDV GTAVENILSK
110 120 130 140 150
KEQTSFFSEN PDLRDVYSDF AYLSSIEGNR SQKEKLKVIR KLFANAGGAE
160 170 180 190 200
GKYLSRLILG ELRIGIGEGN IRDAIAKAFD VPTESVEHAY QAANDLGEIA
210 220 230 240 250
VIAKKGVDEL RAVRISLFRP VKMMLAKQGT IAEMVEEQGA IAAEYKYDGT
260 270 280 290 300
RFQFHKSGDK CRIYSRKLEE VTTAIPDIVD ILVKTTGHDV ILDGEVIAVD
310 320 330 340 350
GNGNPMPFQH VLKRFRRKHD IASHIENIRL VPNIFDILYL DGETLIDKPF
360 370 380 390 400
EERRKILVEN VSLHVAPQIV SDDIITIEAF YREALDAGHE GIMIKSLKSA
410 420 430 440 450
YTPGQRVRQW IKIKPSVDTI DLAVVGAEWG EGKRAHLFGS FILACQDESG
460 470 480 490 500
RLLRISKVAT GFSDEALAGV YDLLKDTEIS ESGKVVSFEP EVVFEVGYAE
510 520 530 540
IQKSTNYEAG YALRFPRFIR FRDDKGIDEI ETISSIEDRF RAQSEKIR
Length:548
Mass (Da):61,463
Last modified:November 30, 2010 - v1
Checksum:i2323FDABED1BE1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002117 Genomic DNA Translation: ADN37147.1
RefSeqiWP_013330324.1, NC_014507.1

Genome annotation databases

EnsemblBacteriaiADN37147; ADN37147; Mpet_2400
GeneIDi9744892
KEGGimpi:Mpet_2400

Similar proteinsi

Entry informationi

Entry nameiE1RDW0_METP4
AccessioniPrimary (citable) accession number: E1RDW0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health