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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Sediminispirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228) (Spirochaeta smaragdinae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
Biological processCobalamin biosynthesisUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

BioCyciSSMA573413:G1GM6-189-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Spirs_0185Imported
OrganismiSediminispirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228) (Spirochaeta smaragdinae)Imported
Taxonomic identifieri573413 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSediminispirochaeta
Proteomesi
  • UP000002318 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573413.Spirs_0185

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E1R8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWYDQELG KVSGMRLGIT TGSCAQAAAR AALEFLLGIF ADKRVEITLP
60 70 80 90 100
KGHRRYSGRQ ILVPVESIGA TSDGTGAEAL VRKDSGDDPD ITDGILIGAR
110 120 130 140 150
VRLKEGNGVE IDGAEGVGRI TRPGLAGKVG EAAINPIPRR MIREELLPLL
160 170 180 190 200
PEGKGCRVEI FVPEGIALAE KTWNPRIGIL GGISIIGTKG VVEPKSEEAY
210 220 230 240 250
KASINRVIHS YLKSGMSRLI ITPGYVGEAF LSSRGIALDR VVTVGDHVGH
260 270 280 290 300
ALLRGADHGA KELLLVGHIG KLTKIAVAMF NTHWSSGDAR LEVIAAYAGA
310 320 330 340 350
AGASAEKVRR LLSLSLAEEA VALIHDWGLD EIWNAIARRA AERTEKLVEG
360 370
RCTIGVVLLD LKGHSLGSWP KERVEGWLK
Length:379
Mass (Da):40,496
Last modified:November 30, 2010 - v1
Checksum:i4A6508D904DD48AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA Translation: ADK79342.1
RefSeqiWP_013252806.1, NC_014364.1

Genome annotation databases

EnsemblBacteriaiADK79342; ADK79342; Spirs_0185
KEGGissm:Spirs_0185

Entry informationi

Entry nameiE1R8J8_SEDSS
AccessioniPrimary (citable) accession number: E1R8J8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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