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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Spirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathway:iadenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Cobalamin biosynthesisUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

BioCyciSSMA573413:GI0C-190-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Spirs_0185Imported
OrganismiSpirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)Imported
Taxonomic identifieri573413 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000002318 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi573413.Spirs_0185.

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E1R8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWYDQELG KVSGMRLGIT TGSCAQAAAR AALEFLLGIF ADKRVEITLP
60 70 80 90 100
KGHRRYSGRQ ILVPVESIGA TSDGTGAEAL VRKDSGDDPD ITDGILIGAR
110 120 130 140 150
VRLKEGNGVE IDGAEGVGRI TRPGLAGKVG EAAINPIPRR MIREELLPLL
160 170 180 190 200
PEGKGCRVEI FVPEGIALAE KTWNPRIGIL GGISIIGTKG VVEPKSEEAY
210 220 230 240 250
KASINRVIHS YLKSGMSRLI ITPGYVGEAF LSSRGIALDR VVTVGDHVGH
260 270 280 290 300
ALLRGADHGA KELLLVGHIG KLTKIAVAMF NTHWSSGDAR LEVIAAYAGA
310 320 330 340 350
AGASAEKVRR LLSLSLAEEA VALIHDWGLD EIWNAIARRA AERTEKLVEG
360 370
RCTIGVVLLD LKGHSLGSWP KERVEGWLK
Length:379
Mass (Da):40,496
Last modified:November 30, 2010 - v1
Checksum:i4A6508D904DD48AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA. Translation: ADK79342.1.
RefSeqiWP_013252806.1. NC_014364.1.

Genome annotation databases

EnsemblBacteriaiADK79342; ADK79342; Spirs_0185.
KEGGissm:Spirs_0185.
PATRICi42524220. VBISpiSma89994_0190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA. Translation: ADK79342.1.
RefSeqiWP_013252806.1. NC_014364.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573413.Spirs_0185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK79342; ADK79342; Spirs_0185.
KEGGissm:Spirs_0185.
PATRICi42524220. VBISpiSma89994_0190.

Phylogenomic databases

HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciSSMA573413:GI0C-190-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11293 / JCM 15392 / SEBR 4228Imported.

Entry informationi

Entry nameiE1R8J8_SPISS
AccessioniPrimary (citable) accession number: E1R8J8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 22, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.