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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Spirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei271 – 2711ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutaminyl-tRNA aminoacylation Source: InterPro
  2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSMA573413:GI0C-1498-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotationSAAS annotation (EC:6.1.1.18UniRule annotationSAAS annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:Spirs_1481Imported
OrganismiSpirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)Imported
Taxonomic identifieri573413 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000002318: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE1R573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4411"HIGH" regionUniRule annotationAdd
BLAST
Motifi268 – 2725"KMSKS" regionUniRule annotation

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1R573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAEKSSLN FIERIIEDDF ARGKHSQVVT RFPPEPNGYL HIGHAKSICL
60 70 80 90 100
NFGLAKKYGG RCHLRFDDTN PEKESLEYIE SIKRDVQWLG FSWGAHEYYA
110 120 130 140 150
SDYFEELYKR AVRLIKAGKA YVDDLSPEQM REYRGTLTKP GKESPNRTRS
160 170 180 190 200
IEENLDLFER MRKGEFPDGS MLLRAKIDMA SGNMNMRDPA LYRIRRINHH
210 220 230 240 250
RTGDAWCIYP MYDFTHPLSD AIEGITHSIC TLEFEDHRPL YDWSVEETEM
260 270 280 290 300
ECHPRQIEFA RLNLTYTVMS KRILLQLVTE GHVSGWDDPR MPTISGLRRR
310 320 330 340 350
GYTPEAIRQF ADIIGVAKVN STVDMALLEH CLREDLNLRA LRVMVVLDPV
360 370 380 390 400
KVVIDNYPEG KEELLEAENN PEDPDGGMRM VPFSREVYIE REDFMEDPPK
410 420 430 440 450
KFFRLAPGRE IRLKHAYYIT CVSVEKNEAG EITTIHCSYD PESRGGGTPD
460 470 480 490 500
GRRVKGTSHW VSVSHAKELE VRLYDNLFTS PEPGSRTGNF LDDLNPDSLS
510 520 530 540 550
TIKAMAEPSL IDAEPEAHYQ FLRKGYFTVD PKESKKGAPV FNRTVTLRDS
560
WAKLQKKIEA
Length:560
Mass (Da):64,472
Last modified:November 30, 2010 - v1
Checksum:i64EE2ED90EC8E409
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA. Translation: ADK80608.1.
RefSeqiWP_013254072.1. NC_014364.1.
YP_003803202.1. NC_014364.1.

Genome annotation databases

EnsemblBacteriaiADK80608; ADK80608; Spirs_1481.
GeneIDi9489570.
KEGGissm:Spirs_1481.
PATRICi42526916. VBISpiSma89994_1526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA. Translation: ADK80608.1.
RefSeqiWP_013254072.1. NC_014364.1.
YP_003803202.1. NC_014364.1.

3D structure databases

ProteinModelPortaliE1R573.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK80608; ADK80608; Spirs_1481.
GeneIDi9489570.
KEGGissm:Spirs_1481.
PATRICi42526916. VBISpiSma89994_1526.

Phylogenomic databases

HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.

Enzyme and pathway databases

BioCyciSSMA573413:GI0C-1498-MONOMER.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11293 / JCM 15392 / SEBR 4228Imported.

Entry informationi

Entry nameiE1R573_SPISS
AccessioniPrimary (citable) accession number: E1R573
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.