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E1R460

- E1R460_SPISS

UniProt

E1R460 - E1R460_SPISS

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Protein
Alanine racemase
Gene
Spirs_1355
Organism
Spirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei311 – 3111Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSSMA573413:GI0C-1372-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Spirs_1355Imported
OrganismiSpirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)Imported
Taxonomic identifieri573413 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000002318: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1R460.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiRTEEWIA.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1R460-1 [UniParc]FASTAAdd to Basket

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MRPTKARIDL DLYRHNIRVI SKKTGGRKIC LVVKANAYGH GSVKMAKVGI    50
EAGAQALGVA TVDEALELRE AGIAAPIFLF TVADVSEVPQ LVRFDIIPFV 100
SDLAYIKQIE REAQNQEKVA MVHLKVDTGM GRLGCRPEEA LSLASFVGNS 150
KNLMMGGLCT HFSLSDISDR AYTLLQINRL NLLVDTLRSQ HIPYGLVHAA 200
NTGAIIQYPE AYYDMVRPGL GIFGYPPDLI HMGRDRADLR PVLSMETKIG 250
LIKTIKKGES VSYGRTFVAE NDTHIGVVAA GFCDGYPRSL SNKGFVTIKG 300
KHYPVIGMVC MDQLIVDLGR DLQVDPDDTV VLLGHGRNEP TMVDLTQRGN 350
IIVNEVICRI PARVPKVYIN E 371
Length:371
Mass (Da):40,768
Last modified:November 30, 2010 - v1
Checksum:i4C8EB89F068EDA6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002116 Genomic DNA. Translation: ADK80482.1.
RefSeqiYP_003803076.1. NC_014364.1.

Genome annotation databases

EnsemblBacteriaiADK80482; ADK80482; Spirs_1355.
GeneIDi9489444.
KEGGissm:Spirs_1355.
PATRICi42526662. VBISpiSma89994_1399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002116 Genomic DNA. Translation: ADK80482.1 .
RefSeqi YP_003803076.1. NC_014364.1.

3D structure databases

ProteinModelPortali E1R460.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADK80482 ; ADK80482 ; Spirs_1355 .
GeneIDi 9489444.
KEGGi ssm:Spirs_1355.
PATRICi 42526662. VBISpiSma89994_1399.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi RTEEWIA.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SSMA573413:GI0C-1372-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11293 / JCM 15392 / SEBR 4228.

Entry informationi

Entry nameiE1R460_SPISS
AccessioniPrimary (citable) accession number: E1R460
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi