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Protein

Alanine racemase

Gene

Spirs_1355

Organism
Spirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Spirs_1047), Alanine racemase (Spirs_1355)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei311 – 3111Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSSMA573413:GI0C-1372-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Spirs_1355Imported
OrganismiSpirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)Imported
Taxonomic identifieri573413 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000002318 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi573413.Spirs_1355.

Structurei

3D structure databases

ProteinModelPortaliE1R460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiRTEEWIA.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1R460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPTKARIDL DLYRHNIRVI SKKTGGRKIC LVVKANAYGH GSVKMAKVGI
60 70 80 90 100
EAGAQALGVA TVDEALELRE AGIAAPIFLF TVADVSEVPQ LVRFDIIPFV
110 120 130 140 150
SDLAYIKQIE REAQNQEKVA MVHLKVDTGM GRLGCRPEEA LSLASFVGNS
160 170 180 190 200
KNLMMGGLCT HFSLSDISDR AYTLLQINRL NLLVDTLRSQ HIPYGLVHAA
210 220 230 240 250
NTGAIIQYPE AYYDMVRPGL GIFGYPPDLI HMGRDRADLR PVLSMETKIG
260 270 280 290 300
LIKTIKKGES VSYGRTFVAE NDTHIGVVAA GFCDGYPRSL SNKGFVTIKG
310 320 330 340 350
KHYPVIGMVC MDQLIVDLGR DLQVDPDDTV VLLGHGRNEP TMVDLTQRGN
360 370
IIVNEVICRI PARVPKVYIN E
Length:371
Mass (Da):40,768
Last modified:November 30, 2010 - v1
Checksum:i4C8EB89F068EDA6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA. Translation: ADK80482.1.
RefSeqiWP_013253946.1. NC_014364.1.
YP_003803076.1. NC_014364.1.

Genome annotation databases

EnsemblBacteriaiADK80482; ADK80482; Spirs_1355.
KEGGissm:Spirs_1355.
PATRICi42526662. VBISpiSma89994_1399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002116 Genomic DNA. Translation: ADK80482.1.
RefSeqiWP_013253946.1. NC_014364.1.
YP_003803076.1. NC_014364.1.

3D structure databases

ProteinModelPortaliE1R460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573413.Spirs_1355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK80482; ADK80482; Spirs_1355.
KEGGissm:Spirs_1355.
PATRICi42526662. VBISpiSma89994_1399.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiRTEEWIA.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSSMA573413:GI0C-1372-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11293 / JCM 15392 / SEBR 4228Imported.

Entry informationi

Entry nameiE1R460_SPISS
AccessioniPrimary (citable) accession number: E1R460
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 24, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.