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E1R3M7 (E1R3M7_SPISS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Spirs_2895 EMBL ADK81998.1
OrganismSpirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228) [Complete proteome] [HAMAP] EMBL ADK81998.1
Taxonomic identifier573413 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain137 – 346210ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding172 – 22756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2991Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3131Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3131Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E1R3M7 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 1E8ACA8E4AD5418A

FASTA36339,979
        10         20         30         40         50         60 
MKRIKVALLF GGKSGEHEVS LVSAASVFKH IDKERFDVAL IAVDKDGAWF LQPQPLYDEK 

        70         80         90        100        110        120 
EGGFVVERKE ENRVYAVPAG GLRTMAKPLD IELVFPVLHG TFGEDGTVQG LLELCDLPYA 

       130        140        150        160        170        180 
GAGVLGSSLC MDKAAVKRIW IQAGLPVVPF EELREVSWKR SKGAAASVRR AVDRFSFPLF 

       190        200        210        220        230        240 
VKPSRAGSSV GVSRCETEEG LYAAIEDAFS FDDKLLIEPA VQAKEIECSV IGNQELTTFA 

       250        260        270        280        290        300 
PGEIVPSHDF YDYDAKYIDP DGANLLIPSS LNEEQQKMVR QISARAYRVA EAEGFARVDC 

       310        320        330        340        350        360 
FYEEATGKVL LNEINTIPGF TKISMFPKLC ENGGVAYGEL LTKLLDLAVD RHKIRGAKSY 


QWS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002116 Genomic DNA. Translation: ADK81998.1.
RefSeqYP_003804592.1. NC_014364.1.

3D structure databases

ProteinModelPortalE1R3M7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADK81998; ADK81998; Spirs_2895.
GeneID9491010.
KEGGssm:Spirs_2895.
PATRIC42529826. VBISpiSma89994_2957.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.

Enzyme and pathway databases

BioCycSSMA573413:GI0C-2938-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE1R3M7_SPISS
AccessionPrimary (citable) accession number: E1R3M7
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)