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Protein

DNA ligase

Gene

lig

Organism
Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei265ATPUniRule annotation1
Active sitei267N6-AMP-lysine intermediateUniRule annotation1
Binding sitei272ATPUniRule annotation1
Binding sitei288ATPUniRule annotation1
Binding sitei318ATPUniRule annotation1
Binding sitei358ATPUniRule annotation1
Binding sitei435ATPUniRule annotation1
Binding sitei441ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Vdis_1519Imported
OrganismiVulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)Imported
Taxonomic identifieri572478 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeVulcanisaeta
Proteomesi
  • UP000006681 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi572478.Vdis_1519

Structurei

3D structure databases

ProteinModelPortaliE1QTB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini346 – 481DNA_LIGASE_A3InterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

E1QTB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSNDIKF IDVVKALESI EATTQRTVMA KLLSSLLKKT PPNVIDKVIY
60 70 80 90 100
FILGQLRPDW EGVELGVAEK LTFRAIANAT GAPIKQIEDL YKRLGDVGET
110 120 130 140 150
ARRIMSSKPQ QGGGKSILEF FGGGGGEELT MGKVYDTLMS IARASGEGAQ
160 170 180 190 200
DTKVKLLTYL FSRAKPEEAK YIARFVIGRL RLGVADMTIL DALSDAYKVP
210 220 230 240 250
REALERAYHI YPDLGYIAKM VAQEGQNALA KIHVTPGVPI QPMLAERLST
260 270 280 290 300
STEILAKLGG VAMVEYKYDG ERAQIHKTRD GEIRIFSRRL ENITHAYPDV
310 320 330 340 350
AEYVKEAIDA KEYIVEGEIV AIDPDTGEFR PFQELMHRKR KHDIKEAMKE
360 370 380 390 400
YPVNIFLFDI MYIDGQDLTN LPLIDRKRKL LEVLKPSEYV HLATWRIIND
410 420 430 440 450
AEELDKFFHE AISDGCEGVM CKSIKADSIY EMGARGWLWI KYKRDYRSEL
460 470 480 490 500
TDTLDLVVVG AFWGRGKRAG TYGALLIAAY DPKTDQFYTV SKVGSGFTDE
510 520 530 540 550
DLVKLKQMLD PYRIPHKHPR VVSKMEPDVW FVPAVVLEII GAEITLSPLH
560 570 580 590 600
TCCMGAIRPG VGLAIRFPRF TGRYRTDKSP EQATTVDEIL EMYKEQKKVK

IEEGANP
Length:607
Mass (Da):68,274
Last modified:November 30, 2010 - v1
Checksum:i5D609492566379E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002100 Genomic DNA Translation: ADN50904.1

Genome annotation databases

EnsemblBacteriaiADN50904; ADN50904; Vdis_1519
KEGGivdi:Vdis_1519

Similar proteinsi

Entry informationi

Entry nameiE1QTB1_VULDI
AccessioniPrimary (citable) accession number: E1QTB1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health