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E1QTB1

- E1QTB1_VULDI

UniProt

E1QTB1 - E1QTB1_VULDI

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Protein
DNA ligase
Gene
lig, Vdis_1519
Organism
Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei265 – 2651ATP By similarityUniRule annotation
Active sitei267 – 2671N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei272 – 2721ATP By similarityUniRule annotation
Binding sitei288 – 2881ATP By similarityUniRule annotation
Binding sitei318 – 3181ATP By similarityUniRule annotation
Binding sitei358 – 3581ATP By similarityUniRule annotation
Binding sitei435 – 4351ATP By similarityUniRule annotation
Binding sitei441 – 4411ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVDIS572478:GHT7-1544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Vdis_1519Imported
OrganismiVulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)Imported
Taxonomic identifieri572478 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeVulcanisaeta
ProteomesiUP000006681: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1QTB1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1QTB1-1 [UniParc]FASTAAdd to Basket

« Hide

MSTGSNDIKF IDVVKALESI EATTQRTVMA KLLSSLLKKT PPNVIDKVIY    50
FILGQLRPDW EGVELGVAEK LTFRAIANAT GAPIKQIEDL YKRLGDVGET 100
ARRIMSSKPQ QGGGKSILEF FGGGGGEELT MGKVYDTLMS IARASGEGAQ 150
DTKVKLLTYL FSRAKPEEAK YIARFVIGRL RLGVADMTIL DALSDAYKVP 200
REALERAYHI YPDLGYIAKM VAQEGQNALA KIHVTPGVPI QPMLAERLST 250
STEILAKLGG VAMVEYKYDG ERAQIHKTRD GEIRIFSRRL ENITHAYPDV 300
AEYVKEAIDA KEYIVEGEIV AIDPDTGEFR PFQELMHRKR KHDIKEAMKE 350
YPVNIFLFDI MYIDGQDLTN LPLIDRKRKL LEVLKPSEYV HLATWRIIND 400
AEELDKFFHE AISDGCEGVM CKSIKADSIY EMGARGWLWI KYKRDYRSEL 450
TDTLDLVVVG AFWGRGKRAG TYGALLIAAY DPKTDQFYTV SKVGSGFTDE 500
DLVKLKQMLD PYRIPHKHPR VVSKMEPDVW FVPAVVLEII GAEITLSPLH 550
TCCMGAIRPG VGLAIRFPRF TGRYRTDKSP EQATTVDEIL EMYKEQKKVK 600
IEEGANP 607
Length:607
Mass (Da):68,274
Last modified:November 30, 2010 - v1
Checksum:i5D609492566379E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002100 Genomic DNA. Translation: ADN50904.1.
RefSeqiWP_013336629.1. NC_014537.1.
YP_003901955.1. NC_014537.1.

Genome annotation databases

EnsemblBacteriaiADN50904; ADN50904; Vdis_1519.
GeneIDi9752456.
KEGGivdi:Vdis_1519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002100 Genomic DNA. Translation: ADN50904.1 .
RefSeqi WP_013336629.1. NC_014537.1.
YP_003901955.1. NC_014537.1.

3D structure databases

ProteinModelPortali E1QTB1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN50904 ; ADN50904 ; Vdis_1519 .
GeneIDi 9752456.
KEGGi vdi:Vdis_1519.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci VDIS572478:GHT7-1544-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14429 / JCM 11212 / NBRC 100878 / IC-017.

Entry informationi

Entry nameiE1QTB1_VULDI
AccessioniPrimary (citable) accession number: E1QTB1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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