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Protein

DNA ligase

Gene

lig

Organism
Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei265 – 2651ATPUniRule annotation
Active sitei267 – 2671N6-AMP-lysine intermediateUniRule annotation
Binding sitei272 – 2721ATPUniRule annotation
Binding sitei288 – 2881ATPUniRule annotation
Binding sitei318 – 3181ATPUniRule annotation
Binding sitei358 – 3581ATPUniRule annotation
Binding sitei435 – 4351ATPUniRule annotation
Binding sitei441 – 4411ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVDIS572478:GHT7-1544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Vdis_1519Imported
OrganismiVulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)Imported
Taxonomic identifieri572478 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeVulcanisaeta
ProteomesiUP000006681: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1QTB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiLACYDEQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1QTB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSNDIKF IDVVKALESI EATTQRTVMA KLLSSLLKKT PPNVIDKVIY
60 70 80 90 100
FILGQLRPDW EGVELGVAEK LTFRAIANAT GAPIKQIEDL YKRLGDVGET
110 120 130 140 150
ARRIMSSKPQ QGGGKSILEF FGGGGGEELT MGKVYDTLMS IARASGEGAQ
160 170 180 190 200
DTKVKLLTYL FSRAKPEEAK YIARFVIGRL RLGVADMTIL DALSDAYKVP
210 220 230 240 250
REALERAYHI YPDLGYIAKM VAQEGQNALA KIHVTPGVPI QPMLAERLST
260 270 280 290 300
STEILAKLGG VAMVEYKYDG ERAQIHKTRD GEIRIFSRRL ENITHAYPDV
310 320 330 340 350
AEYVKEAIDA KEYIVEGEIV AIDPDTGEFR PFQELMHRKR KHDIKEAMKE
360 370 380 390 400
YPVNIFLFDI MYIDGQDLTN LPLIDRKRKL LEVLKPSEYV HLATWRIIND
410 420 430 440 450
AEELDKFFHE AISDGCEGVM CKSIKADSIY EMGARGWLWI KYKRDYRSEL
460 470 480 490 500
TDTLDLVVVG AFWGRGKRAG TYGALLIAAY DPKTDQFYTV SKVGSGFTDE
510 520 530 540 550
DLVKLKQMLD PYRIPHKHPR VVSKMEPDVW FVPAVVLEII GAEITLSPLH
560 570 580 590 600
TCCMGAIRPG VGLAIRFPRF TGRYRTDKSP EQATTVDEIL EMYKEQKKVK

IEEGANP
Length:607
Mass (Da):68,274
Last modified:November 30, 2010 - v1
Checksum:i5D609492566379E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002100 Genomic DNA. Translation: ADN50904.1.
RefSeqiWP_013336629.1. NC_014537.1.
YP_003901955.1. NC_014537.1.

Genome annotation databases

EnsemblBacteriaiADN50904; ADN50904; Vdis_1519.
GeneIDi9752456.
KEGGivdi:Vdis_1519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002100 Genomic DNA. Translation: ADN50904.1.
RefSeqiWP_013336629.1. NC_014537.1.
YP_003901955.1. NC_014537.1.

3D structure databases

ProteinModelPortaliE1QTB1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADN50904; ADN50904; Vdis_1519.
GeneIDi9752456.
KEGGivdi:Vdis_1519.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiLACYDEQ.

Enzyme and pathway databases

BioCyciVDIS572478:GHT7-1544-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14429 / JCM 11212 / NBRC 100878 / IC-017Imported.

Entry informationi

Entry nameiE1QTB1_VULDI
AccessioniPrimary (citable) accession number: E1QTB1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.