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Protein
Submitted name:

D-alanine--D-alanine ligase domain protein

Gene

Deba_0210

Organism
Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDBAA644282:GH2J-213-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligase domain proteinImported
Gene namesi
Ordered Locus Names:Deba_0210Imported
OrganismiDesulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)Imported
Taxonomic identifieri644282 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfarculalesDesulfarculaceaeDesulfarculus
Proteomesi
  • UP000009047 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi644282.Deba_0210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 322ATP-graspInterPro annotationAdd BLAST214

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108PB3. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011594.
KOiK01921.
OMAiMATARES.
OrthoDBiPOG091H00GT.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1QG75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVVLHDMA SPDAAPDLAD NVVQASQVLA ALGRLGHRAQ GLAFGPEVDQ
60 70 80 90 100
TRQALEELRP DVVFNLVETP LGMARMIHLA PLLLERLRLR YTGAGARGML
110 120 130 140 150
LTSQKLLAKK AMRESNLPTP DWCGPRDDGL PFSPLRRYIV KSVWEHGSVG
160 170 180 190 200
LDDHSIIKPL GRAAMRAAIA QRGKALGGDC FAEAYIDGRE FNIAILAGSR
210 220 230 240 250
GPEVLPPAEI TFEGFQPGKP HIVGYRAKWV EDSHEYNHTP RRFDFEPRDA
260 270 280 290 300
ELLARLKAMS LRCWRLFGLR GWARVDFRVD RKGRPFILEV NANPCLADDA
310 320 330 340
GFMAAARRAG LDQTIVVWRI LGSASRGRRR GCAVEKTGLA
Length:340
Mass (Da):37,568
Last modified:November 30, 2010 - v1
Checksum:i9754DAC7F76796F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002085 Genomic DNA. Translation: ADK83587.1.
RefSeqiWP_013257043.1. NC_014365.1.

Genome annotation databases

EnsemblBacteriaiADK83587; ADK83587; Deba_0210.
KEGGidbr:Deba_0210.
PATRICi42295789. VBIDesBaa100999_0216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002085 Genomic DNA. Translation: ADK83587.1.
RefSeqiWP_013257043.1. NC_014365.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644282.Deba_0210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK83587; ADK83587; Deba_0210.
KEGGidbr:Deba_0210.
PATRICi42295789. VBIDesBaa100999_0216.

Phylogenomic databases

eggNOGiENOG4108PB3. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011594.
KOiK01921.
OMAiMATARES.
OrthoDBiPOG091H00GT.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciDBAA644282:GH2J-213-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE1QG75_DESB2
AccessioniPrimary (citable) accession number: E1QG75
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.