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E1Q589

- E1Q589_HELPP

UniProt

E1Q589 - E1Q589_HELPP

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Protein
Ketol-acid reductoisomerase
Gene
ilvC, HPPC_01675
Organism
Helicobacter pylori (strain PeCan4)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotations
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091 By similarityUniRule annotation

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. isomerase activity Source: UniProtKB-KW
  3. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHPYL765963:GH9T-325-MONOMER.
UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvCUniRule annotation
Ordered Locus Names:HPPC_01675Imported
OrganismiHelicobacter pylori (strain PeCan4)Imported
Taxonomic identifieri765963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000006863: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1Q589.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000016230.
KOiK00053.
OMAiQSDVIMA.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

E1Q589-1 [UniParc]FASTAAdd to Basket

« Hide

MALPVYYDKD IDLGVIQSLQ VGIIGYGAQG EAQALNLRDS KVKVRIGLYQ    50
GSLSVSKAKA EGFEVLEVKE LVQQSDVIMA LLPDELHKEV LEKEVIPFLK 100
EGQIVGFAHG FSVHFNQVVL PKGVGAILVA PKGPGSALRE EYLKNRGLYH 150
LIAIEQESSK NNAKAVALSY AKAMGGGRMG VLETSFKEEC ESDLFGEQAV 200
LCGGLEAIVR MGFETLIKAG YPEELAYFEC VHEVKLVADL LHYKGVEGLR 250
KHISNTAEFG AIKAREPMGN LLEKRMQKIL KKIQNGAFAK DFLLEKSLNY 300
PRLNTERKAL KETKIEQIGE ILRVPFNHKK 330
Length:330
Mass (Da):36,509
Last modified:November 30, 2010 - v1
Checksum:i793FCE7631E58AD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002074 Genomic DNA. Translation: ADO06580.1.
RefSeqiWP_001207749.1. NC_014555.1.
YP_003926630.1. NC_014555.1.

Genome annotation databases

EnsemblBacteriaiADO06580; ADO06580; HPPC_01675.
GeneIDi9785405.
KEGGihpc:HPPC_01675.
PATRICi42490759. VBIHelPyl173672_0344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002074 Genomic DNA. Translation: ADO06580.1 .
RefSeqi WP_001207749.1. NC_014555.1.
YP_003926630.1. NC_014555.1.

3D structure databases

ProteinModelPortali E1Q589.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO06580 ; ADO06580 ; HPPC_01675 .
GeneIDi 9785405.
KEGGi hpc:HPPC_01675.
PATRICi 42490759. VBIHelPyl173672_0344.

Phylogenomic databases

HOGENOMi HOG000016230.
KOi K00053.
OMAi QSDVIMA.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .
BioCyci HPYL765963:GH9T-325-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Helicobacter pylori strain PeCan4."
    Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PeCan4.

Entry informationi

Entry nameiE1Q589_HELPP
AccessioniPrimary (citable) accession number: E1Q589
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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