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Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Helicobacter pylori (strain PeCan4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotation
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL765963:GH9T-325-MONOMER.
UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomeraseUniRule annotationSAAS annotation (EC:1.1.1.86UniRule annotationSAAS annotation)
Alternative name(s):
Acetohydroxy-acid isomeroreductaseUniRule annotation
Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
Gene namesi
Name:ilvCUniRule annotation
Ordered Locus Names:HPPC_01675Imported
OrganismiHelicobacter pylori (strain PeCan4)Imported
Taxonomic identifieri765963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000006863 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1Q589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketol-acid reductoisomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000016230.
KOiK00053.
OMAiVYYDKDI.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

E1Q589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPVYYDKD IDLGVIQSLQ VGIIGYGAQG EAQALNLRDS KVKVRIGLYQ
60 70 80 90 100
GSLSVSKAKA EGFEVLEVKE LVQQSDVIMA LLPDELHKEV LEKEVIPFLK
110 120 130 140 150
EGQIVGFAHG FSVHFNQVVL PKGVGAILVA PKGPGSALRE EYLKNRGLYH
160 170 180 190 200
LIAIEQESSK NNAKAVALSY AKAMGGGRMG VLETSFKEEC ESDLFGEQAV
210 220 230 240 250
LCGGLEAIVR MGFETLIKAG YPEELAYFEC VHEVKLVADL LHYKGVEGLR
260 270 280 290 300
KHISNTAEFG AIKAREPMGN LLEKRMQKIL KKIQNGAFAK DFLLEKSLNY
310 320 330
PRLNTERKAL KETKIEQIGE ILRVPFNHKK
Length:330
Mass (Da):36,509
Last modified:November 30, 2010 - v1
Checksum:i793FCE7631E58AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002074 Genomic DNA. Translation: ADO06580.1.
RefSeqiWP_001207749.1. NC_014555.1.
YP_003926630.1. NC_014555.1.

Genome annotation databases

EnsemblBacteriaiADO06580; ADO06580; HPPC_01675.
KEGGihpc:HPPC_01675.
PATRICi42490759. VBIHelPyl173672_0344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002074 Genomic DNA. Translation: ADO06580.1.
RefSeqiWP_001207749.1. NC_014555.1.
YP_003926630.1. NC_014555.1.

3D structure databases

ProteinModelPortaliE1Q589.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO06580; ADO06580; HPPC_01675.
KEGGihpc:HPPC_01675.
PATRICi42490759. VBIHelPyl173672_0344.

Phylogenomic databases

HOGENOMiHOG000016230.
KOiK00053.
OMAiVYYDKDI.

Enzyme and pathway databases

UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.
BioCyciHPYL765963:GH9T-325-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Helicobacter pylori strain PeCan4."
    Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PeCan4Imported.

Entry informationi

Entry nameiE1Q589_HELPP
AccessioniPrimary (citable) accession number: E1Q589
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 27, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.