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E1Q589

- E1Q589_HELPP

UniProt

E1Q589 - E1Q589_HELPP

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Helicobacter pylori (strain PeCan4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotation
    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei109 – 1091UniRule annotation

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. isomerase activity Source: UniProtKB-KW
    3. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHPYL765963:GH9T-325-MONOMER.
    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:HPPC_01675Imported
    OrganismiHelicobacter pylori (strain PeCan4)Imported
    Taxonomic identifieri765963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000006863: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE1Q589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiQSDVIMA.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E1Q589-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPVYYDKD IDLGVIQSLQ VGIIGYGAQG EAQALNLRDS KVKVRIGLYQ    50
    GSLSVSKAKA EGFEVLEVKE LVQQSDVIMA LLPDELHKEV LEKEVIPFLK 100
    EGQIVGFAHG FSVHFNQVVL PKGVGAILVA PKGPGSALRE EYLKNRGLYH 150
    LIAIEQESSK NNAKAVALSY AKAMGGGRMG VLETSFKEEC ESDLFGEQAV 200
    LCGGLEAIVR MGFETLIKAG YPEELAYFEC VHEVKLVADL LHYKGVEGLR 250
    KHISNTAEFG AIKAREPMGN LLEKRMQKIL KKIQNGAFAK DFLLEKSLNY 300
    PRLNTERKAL KETKIEQIGE ILRVPFNHKK 330
    Length:330
    Mass (Da):36,509
    Last modified:November 30, 2010 - v1
    Checksum:i793FCE7631E58AD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002074 Genomic DNA. Translation: ADO06580.1.
    RefSeqiWP_001207749.1. NC_014555.1.
    YP_003926630.1. NC_014555.1.

    Genome annotation databases

    EnsemblBacteriaiADO06580; ADO06580; HPPC_01675.
    GeneIDi9785405.
    KEGGihpc:HPPC_01675.
    PATRICi42490759. VBIHelPyl173672_0344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002074 Genomic DNA. Translation: ADO06580.1 .
    RefSeqi WP_001207749.1. NC_014555.1.
    YP_003926630.1. NC_014555.1.

    3D structure databases

    ProteinModelPortali E1Q589.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO06580 ; ADO06580 ; HPPC_01675 .
    GeneIDi 9785405.
    KEGGi hpc:HPPC_01675.
    PATRICi 42490759. VBIHelPyl173672_0344.

    Phylogenomic databases

    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi QSDVIMA.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .
    BioCyci HPYL765963:GH9T-325-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Helicobacter pylori strain PeCan4."
      Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
      Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PeCan4Imported.

    Entry informationi

    Entry nameiE1Q589_HELPP
    AccessioniPrimary (citable) accession number: E1Q589
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3