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E1Q589

- E1Q589_HELPP

UniProt

E1Q589 - E1Q589_HELPP

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Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Helicobacter pylori (strain PeCan4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotation
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091UniRule annotation

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. isomerase activity Source: UniProtKB-KW
  3. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL765963:GH9T-325-MONOMER.
UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
Alternative name(s):
Acetohydroxy-acid isomeroreductaseUniRule annotation
Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
Gene namesi
Name:ilvCUniRule annotation
Ordered Locus Names:HPPC_01675Imported
OrganismiHelicobacter pylori (strain PeCan4)Imported
Taxonomic identifieri765963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000006863: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1Q589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketol-acid reductoisomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000016230.
KOiK00053.
OMAiQSDVIMA.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

E1Q589-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPVYYDKD IDLGVIQSLQ VGIIGYGAQG EAQALNLRDS KVKVRIGLYQ
60 70 80 90 100
GSLSVSKAKA EGFEVLEVKE LVQQSDVIMA LLPDELHKEV LEKEVIPFLK
110 120 130 140 150
EGQIVGFAHG FSVHFNQVVL PKGVGAILVA PKGPGSALRE EYLKNRGLYH
160 170 180 190 200
LIAIEQESSK NNAKAVALSY AKAMGGGRMG VLETSFKEEC ESDLFGEQAV
210 220 230 240 250
LCGGLEAIVR MGFETLIKAG YPEELAYFEC VHEVKLVADL LHYKGVEGLR
260 270 280 290 300
KHISNTAEFG AIKAREPMGN LLEKRMQKIL KKIQNGAFAK DFLLEKSLNY
310 320 330
PRLNTERKAL KETKIEQIGE ILRVPFNHKK
Length:330
Mass (Da):36,509
Last modified:November 30, 2010 - v1
Checksum:i793FCE7631E58AD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002074 Genomic DNA. Translation: ADO06580.1.
RefSeqiYP_003926630.1. NC_014555.1.

Genome annotation databases

EnsemblBacteriaiADO06580; ADO06580; HPPC_01675.
GeneIDi9785405.
KEGGihpc:HPPC_01675.
PATRICi42490759. VBIHelPyl173672_0344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002074 Genomic DNA. Translation: ADO06580.1 .
RefSeqi YP_003926630.1. NC_014555.1.

3D structure databases

ProteinModelPortali E1Q589.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO06580 ; ADO06580 ; HPPC_01675 .
GeneIDi 9785405.
KEGGi hpc:HPPC_01675.
PATRICi 42490759. VBIHelPyl173672_0344.

Phylogenomic databases

HOGENOMi HOG000016230.
KOi K00053.
OMAi QSDVIMA.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .
BioCyci HPYL765963:GH9T-325-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Helicobacter pylori strain PeCan4."
    Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PeCan4Imported.

Entry informationi

Entry nameiE1Q589_HELPP
AccessioniPrimary (citable) accession number: E1Q589
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3