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E1Q589 (E1Q589_HELPP) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP-Rule MF_00435

EC=1.1.1.86 HAMAP-Rule MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP-Rule MF_00435
Alpha-keto-beta-hydroxylacyl reductoisomerase HAMAP-Rule MF_00435
Gene names
Name:ilvC HAMAP-Rule MF_00435
Ordered Locus Names:HPPC_01675 EMBL ADO06580.1
OrganismHelicobacter pylori (strain PeCan4) [Complete proteome] [HAMAP] EMBL ADO06580.1
Taxonomic identifier765963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 SAAS SAAS013023

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 SAAS SAAS013023

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435 SAAS SAAS013023

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435 SAAS SAAS013023

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP-Rule MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1091 By similarity HAMAP-Rule MF_00435

Sequences

Sequence LengthMass (Da)Tools
E1Q589 [UniParc].

Last modified November 30, 2010. Version 1.
Checksum: 793FCE7631E58AD1

FASTA33036,509
        10         20         30         40         50         60 
MALPVYYDKD IDLGVIQSLQ VGIIGYGAQG EAQALNLRDS KVKVRIGLYQ GSLSVSKAKA 

        70         80         90        100        110        120 
EGFEVLEVKE LVQQSDVIMA LLPDELHKEV LEKEVIPFLK EGQIVGFAHG FSVHFNQVVL 

       130        140        150        160        170        180 
PKGVGAILVA PKGPGSALRE EYLKNRGLYH LIAIEQESSK NNAKAVALSY AKAMGGGRMG 

       190        200        210        220        230        240 
VLETSFKEEC ESDLFGEQAV LCGGLEAIVR MGFETLIKAG YPEELAYFEC VHEVKLVADL 

       250        260        270        280        290        300 
LHYKGVEGLR KHISNTAEFG AIKAREPMGN LLEKRMQKIL KKIQNGAFAK DFLLEKSLNY 

       310        320        330 
PRLNTERKAL KETKIEQIGE ILRVPFNHKK 

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References

[1]"Complete genome sequence of Helicobacter pylori strain PeCan4."
Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PeCan4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002074 Genomic DNA. Translation: ADO06580.1.
RefSeqYP_003926630.1. NC_014555.1.

3D structure databases

ProteinModelPortalE1Q589.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADO06580; ADO06580; HPPC_01675.
GeneID9785405.
KEGGhpc:HPPC_01675.
PATRIC42490759. VBIHelPyl173672_0344.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000016230.
KOK00053.
OMAQSDVIMA.

Enzyme and pathway databases

BioCycHPYL765963:GH9T-325-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE1Q589_HELPP
AccessionPrimary (citable) accession number: E1Q589
Entry history
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)