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Protein

Adenylosuccinate lyase

Gene

HPPC_05405

Organism
Helicobacter pylori (strain PeCan4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciHPYL765963:GH9T-1057-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:HPPC_05405Imported
OrganismiHelicobacter pylori (strain PeCan4)Imported
Taxonomic identifieri765963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000006863 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE1Q345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033912.
KOiK01756.
OMAiPKNMLKN.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1Q345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERYANEEM KALWNEQTKF ETYLEVEKAV VRAWNKLGQI QDSDCEKICS
60 70 80 90 100
KAAFNLERIK EIEKTTKHDL IAFTTCVAES LGEESRFFHY GITSSDCIDT
110 120 130 140 150
AMALLMTKSL KLIQKGVKNL YETLKNRALE HKDTLMVGRS HGVFGEPITF
160 170 180 190 200
GLVLALFADE IKRHLKALDL TMEFISVGAI SGAMGNFAHA PLELEELACE
210 220 230 240 250
FLGLKTANIS NQVIQRDRYA RLACDLALLA SSCEKIAVNI RHLQRSEVYE
260 270 280 290 300
VEEAFSAGQK GSSAMPHKRN PILSENITGL CRVIRSFTTP MLENVALWHE
310 320 330 340 350
RDMSHSSVER FALPDLFITS DFMLSRLNSV IENLVVYPKN MLKNLALSGG
360 370 380 390 400
LVFSQRVLLE LPKKGLSREE SYSIVQENAM KIWEILQQGA FKNADENLFL
410 420 430 440
NALLNDERLK KYLSEDEIKA CFDYSYYTKN VGAIFKRVFG
Length:440
Mass (Da):49,901
Last modified:November 30, 2010 - v1
Checksum:iCEA05672E00044B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002074 Genomic DNA. Translation: ADO07293.1.
RefSeqiWP_000893889.1. NC_014555.1.
YP_003927343.1. NC_014555.1.

Genome annotation databases

EnsemblBacteriaiADO07293; ADO07293; HPPC_05405.
KEGGihpc:HPPC_05405.
PATRICi42492309. VBIHelPyl173672_1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002074 Genomic DNA. Translation: ADO07293.1.
RefSeqiWP_000893889.1. NC_014555.1.
YP_003927343.1. NC_014555.1.

3D structure databases

ProteinModelPortaliE1Q345.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO07293; ADO07293; HPPC_05405.
KEGGihpc:HPPC_05405.
PATRICi42492309. VBIHelPyl173672_1099.

Phylogenomic databases

HOGENOMiHOG000033912.
KOiK01756.
OMAiPKNMLKN.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.
BioCyciHPYL765963:GH9T-1057-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Helicobacter pylori strain PeCan4."
    Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PeCan4Imported.

Entry informationi

Entry nameiE1Q345_HELPP
AccessioniPrimary (citable) accession number: E1Q345
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 27, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.