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E1Q2S1

- E1Q2S1_HELPP

UniProt

E1Q2S1 - E1Q2S1_HELPP

Protein

Alanine racemase

Gene

HPPC_04750

Organism
Helicobacter pylori (strain PeCan4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHPYL765963:GH9T-920-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:HPPC_04750Imported
    OrganismiHelicobacter pylori (strain PeCan4)Imported
    Taxonomic identifieri765963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000006863: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE1Q2S1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiPSECAGV.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E1Q2S1-1 [UniParc]FASTAAdd to Basket

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    MLKRASFVEV DTASLRHNFS AVKSIVPKDA HIMAVVKANA YGVGAIKASE    50
    IFLQEGANYL GVATLDEALE LRSHFSKTPI LILGYSPNSN ASMLIDNDLS 100
    AMIFSLEQAE VFSQMALKSQ KRLKIHLKID TGMHRLGLEP NFKSIETIKK 150
    IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY 200
    RHAYNSAGIL SLCNGNENRF LNLYRPGIML YGFYPSNGMK ETCPTILKNV 250
    ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRALGN 300
    RTQVAINNQL APLIGKVCMD QCFVKLNNIQ AKEGDEVILF GDKSAKANDA 350
    SEIAALLNTI PYETISTLSK RLERVYI 377
    Length:377
    Mass (Da):41,857
    Last modified:November 30, 2010 - v1
    Checksum:iF4D2850873C0E28F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002074 Genomic DNA. Translation: ADO07169.1.
    RefSeqiYP_003927219.1. NC_014555.1.

    Genome annotation databases

    EnsemblBacteriaiADO07169; ADO07169; HPPC_04750.
    GeneIDi9786000.
    KEGGihpc:HPPC_04750.
    PATRICi42492015. VBIHelPyl173672_0964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002074 Genomic DNA. Translation: ADO07169.1 .
    RefSeqi YP_003927219.1. NC_014555.1.

    3D structure databases

    ProteinModelPortali E1Q2S1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO07169 ; ADO07169 ; HPPC_04750 .
    GeneIDi 9786000.
    KEGGi hpc:HPPC_04750.
    PATRICi 42492015. VBIHelPyl173672_0964.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi PSECAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci HPYL765963:GH9T-920-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Helicobacter pylori strain PeCan4."
      Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.
      Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PeCan4Imported.

    Entry informationi

    Entry nameiE1Q2S1_HELPP
    AccessioniPrimary (citable) accession number: E1Q2S1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3