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Protein

Alanine racemase

Gene

HPSJM_04795

Organism
Helicobacter pylori (strain SJM180)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (HPSJM_04795)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL765962:GH29-944-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:HPSJM_04795Imported
OrganismiHelicobacter pylori (strain SJM180)Imported
Taxonomic identifieri765962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000006862 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1Q049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1Q049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRASFVEV DTASLRHNFH AVKSIVPKDA CIMAVVKANA YGAGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSHFSKTPI LILGYSPNAN ASMLVDNDLS
110 120 130 140 150
AMVFSLEQAE VFSQMALKSQ KRLKVHIKID TGMHRLGLEP NFKSIETIKK
160 170 180 190 200
IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNEMK ESCPTILKNV
260 270 280 290 300
ISLKARIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRALGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNDIE AKEGDEVILF GDKSAKANDA
360 370
SEIAALLNTI PYETISTLSK RLERVYV
Length:377
Mass (Da):41,839
Last modified:November 30, 2010 - v1
Checksum:i7BF562FA3CF7EBEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002073 Genomic DNA. Translation: ADO02540.1.
RefSeqiWP_000917901.1. NC_014560.1.
YP_003928857.1. NC_014560.1.

Genome annotation databases

EnsemblBacteriaiADO02540; ADO02540; HPSJM_04795.
KEGGihpm:HPSJM_04795.
PATRICi42495388. VBIHelPyl169273_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002073 Genomic DNA. Translation: ADO02540.1.
RefSeqiWP_000917901.1. NC_014560.1.
YP_003928857.1. NC_014560.1.

3D structure databases

ProteinModelPortaliE1Q049.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO02540; ADO02540; HPSJM_04795.
KEGGihpm:HPSJM_04795.
PATRICi42495388. VBIHelPyl169273_0955.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciHPYL765962:GH29-944-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Helicobacter pylori strain SJM180."
    Kersulyte D., Velapatino B., Gilman R.H., Berg D.E.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SJM180Imported.

Entry informationi

Entry nameiE1Q049_HELPM
AccessioniPrimary (citable) accession number: E1Q049
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.