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E1Q049

- E1Q049_HELPM

UniProt

E1Q049 - E1Q049_HELPM

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Protein

Alanine racemase

Gene

HPSJM_04795

Organism
Helicobacter pylori (strain SJM180)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL765962:GH29-944-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:HPSJM_04795Imported
OrganismiHelicobacter pylori (strain SJM180)Imported
Taxonomic identifieri765962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000006862: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE1Q049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSECAGV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1Q049-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKRASFVEV DTASLRHNFH AVKSIVPKDA CIMAVVKANA YGAGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSHFSKTPI LILGYSPNAN ASMLVDNDLS
110 120 130 140 150
AMVFSLEQAE VFSQMALKSQ KRLKVHIKID TGMHRLGLEP NFKSIETIKK
160 170 180 190 200
IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNEMK ESCPTILKNV
260 270 280 290 300
ISLKARIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRALGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNDIE AKEGDEVILF GDKSAKANDA
360 370
SEIAALLNTI PYETISTLSK RLERVYV
Length:377
Mass (Da):41,839
Last modified:November 30, 2010 - v1
Checksum:i7BF562FA3CF7EBEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002073 Genomic DNA. Translation: ADO02540.1.
RefSeqiWP_000917901.1. NC_014560.1.
YP_003928857.1. NC_014560.1.

Genome annotation databases

EnsemblBacteriaiADO02540; ADO02540; HPSJM_04795.
GeneIDi9787677.
KEGGihpm:HPSJM_04795.
PATRICi42495388. VBIHelPyl169273_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002073 Genomic DNA. Translation: ADO02540.1 .
RefSeqi WP_000917901.1. NC_014560.1.
YP_003928857.1. NC_014560.1.

3D structure databases

ProteinModelPortali E1Q049.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO02540 ; ADO02540 ; HPSJM_04795 .
GeneIDi 9787677.
KEGGi hpm:HPSJM_04795.
PATRICi 42495388. VBIHelPyl169273_0955.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi PSECAGV.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL765962:GH29-944-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Helicobacter pylori strain SJM180."
    Kersulyte D., Velapatino B., Gilman R.H., Berg D.E.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SJM180Imported.

Entry informationi

Entry nameiE1Q049_HELPM
AccessioniPrimary (citable) accession number: E1Q049
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3