E1P733 (E1P733_ECOAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase HAMAP-Rule MF_00101
Short name=Holo-ACP synthase HAMAP-Rule MF_00101
EC=2.7.8.7 HAMAP-Rule MF_00101

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS HAMAP-Rule MF_00101

Gene names

Name:	acpS HAMAP-Rule MF_00101 EMBL ADN47357.1
Ordered Locus Names:	ECABU_c28650 EMBL ADN47357.1

Organism

Escherichia coli OR:K5:H- (strain ABU 83972) [Complete proteome] [HAMAP] EMBL ADN47357.1

Taxonomic identifier

655817 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP-Rule MF_00101 SAAS SAAS002582
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP-Rule MF_00101 SAAS SAAS002582
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00101 SAAS SAAS002582
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00101 SAAS SAAS002582.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family. HAMAP-Rule MF_00101

Ontologies

Keywords
Biological process	Fatty acid biosynthesis HAMAP-Rule MF_00101 SAAS SAAS002582 Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm HAMAP-Rule MF_00101 SAAS SAAS002582
Ligand	Magnesium HAMAP-Rule MF_00101 SAAS SAAS002582 Metal-binding HAMAP-Rule MF_00101 SAAS SAAS002582
Molecular function	Transferase HAMAP-Rule MF_00101 SAAS SAAS002582 EMBL ADN47357.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	9	1	Magnesium By similarity HAMAP-Rule MF_00101
	Metal binding	58	1	Magnesium By similarity HAMAP-Rule MF_00101

Sequences

	Sequence		Length	Mass (Da)
	E1P733 [UniParc]. Last modified November 30, 2010. Version 1. Checksum: 4D0738210F742AFF	FASTA	126	14,152
	10 20 30 40 50 60 MAILGLGTDI VEIARIEAVI ARSGERLARR VLSDNEWEIW KTHHQPVRFL AKRFAVKEAA 70 80 90 100 110 120 AKAFGTGIRN GLAFNQFEVF NDELGKPRLR LWGEALKLAE KLGVVNMHVT LADERHYACA TVIIES

References

[1]

"Host imprints on bacterial genomes--rapid, divergent evolution in individual patients." Zdziarski J., Brzuszkiewicz E., Wullt B., Liesegang H., Biran D., Voigt B., Gronberg-Hernandez J., Ragnarsdottir B., Hecker M., Ron E.Z., Daniel R., Gottschalk G., Hacker J., Svanborg C., Dobrindt U. PLoS Pathog. 6:e1001078-e1001078(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ABU 83972 EMBL ADN47357.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001671 Genomic DNA. Translation: ADN47357.1.
RefSeq	YP_006106888.1. NC_017631.1.
3D structure databases
ProteinModelPortal	E1P733.
SMR	E1P733. Positions 2-125.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADN47357; ADN47357; ECABU_c28650.
GeneID	12728186.
KEGG	eab:ECABU_c28650.
PATRIC	42950540. VBIEscCol35126_2986.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000014316.
KO	K00997.
OMA	VHVSITH.
Family and domain databases
Gene3D	3.90.470.20. 1 hit.
HAMAP	MF_00101. AcpS.
InterPro	IPR008278. 4-PPantetheinyl_Trfase_SF. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase_dom. [Graphical view]
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. acpS. 1 hit. TIGR00556. pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E1P733_ECOAB

Accession

Primary (citable) accession number: E1P733

Entry history

Integrated into UniProtKB/TrEMBL:	November 30, 2010
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)