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E1C6M9

- E1C6M9_CHICK

UniProt

E1C6M9 - E1C6M9_CHICK

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Protein
Submitted name:

Cadherin-1

Gene

CDH1

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

Cadherins are calcium dependent cell adhesion proteins.UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: Ensembl
  2. cellular response to amino acid stimulus Source: Ensembl
  3. cellular response to indole-3-methanol Source: Ensembl
  4. cellular response to lithium ion Source: Ensembl
  5. cochlea development Source: Ensembl
  6. epithelial cell morphogenesis Source: Ensembl
  7. establishment of protein localization to plasma membrane Source: Ensembl
  8. homophilic cell adhesion Source: InterPro
  9. intestinal epithelial cell development Source: Ensembl
  10. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  11. negative regulation of cell-cell adhesion Source: Ensembl
  12. negative regulation of epithelial cell proliferation Source: Ensembl
  13. positive regulation of transcription, DNA-templated Source: Ensembl
  14. positive regulation of transcription factor import into nucleus Source: Ensembl
  15. protein homooligomerization Source: Ensembl
  16. protein metabolic process Source: Ensembl
  17. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  18. regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  19. regulation of neuron migration Source: Ensembl
  20. regulation of protein localization to cell surface Source: Ensembl
  21. regulation of water loss via skin Source: Ensembl
  22. salivary gland cavitation Source: Ensembl
  23. sensory perception of sound Source: Ensembl
  24. single organismal cell-cell adhesion Source: Ensembl
  25. tight junction assembly Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Keywords - Ligandi

CalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cadherin-1Imported
Gene namesi
Name:CDH1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 11

Subcellular locationi

Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. aggresome Source: Ensembl
  3. apical junction complex Source: Ensembl
  4. apical part of cell Source: Ensembl
  5. axon terminus Source: Ensembl
  6. basolateral plasma membrane Source: Ensembl
  7. catenin complex Source: Ensembl
  8. cell-cell adherens junction Source: Ensembl
  9. cell surface Source: Ensembl
  10. cytoplasmic side of plasma membrane Source: Ensembl
  11. extracellular vesicular exosome Source: Ensembl
  12. focal adhesion Source: Ensembl
  13. integral component of membrane Source: UniProtKB-KW
  14. lateral loop Source: Ensembl
  15. lateral plasma membrane Source: Ensembl
  16. node of Ranvier Source: Ensembl
  17. perinuclear region of cytoplasm Source: Ensembl
  18. Schmidt-Lanterman incisure Source: Ensembl
  19. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118906.
KOiK05689.
OrthoDBiEOG7PS1DS.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1C6M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRRWGSPAL QRFPVLVLLL LLQVCGQRCD EAAPCQPGFA AETFSFSVPQ
60 70 80 90 100
DSVAAGRELG RVSFAACSGR PWAVYVPTDT RFKVNGDGVV STKRPLTLYG
110 120 130 140 150
RKISFTIYAQ DAMGKRHSAR VTVGRHRHRR HHHNHHLQDT TPAVLTFPKH
160 170 180 190 200
DPGFLRRQKR DWVIPPISCL ENHRGPYPMR LVQIKSNKDK ESKVYYSITG
210 220 230 240 250
QGADSPPVGI FIIERETGWL EVTEQLDREK IDRYTLLSHA VSASGQPVED
260 270 280 290 300
PMEIIITVMD QNDNKPVFIK EVFVGYIEEN AKPGTSVMTV NATDADDAVN
310 320 330 340 350
TDNGIVSYSI VSQQPPRPHP QMFTIDPAKG IISVLGTGLD RETTPNYTLI
360 370 380 390 400
VQATDQEGKG LSNTATAIIE VTDANDNIPI FNPTMYEGVV EENKPGTEVA
410 420 430 440 450
RLTVTDQDAP GSPAWQAVYH IKSGNLDGAF SIITDPSTNN GILKTAKGLD
460 470 480 490 500
YETKSRYDLV VTVENKVPLS VPITLSTASV LVTVLDVNEP PVFVPPIKRV
510 520 530 540 550
GVPEDLPVGQ QVTSYTAQDP DRDMRQKITY RMGSDPAGWL YIHPENGIVT
560 570 580 590 600
ATQPLDRESV HAINSTYKAI ILAVDNGIPD TTGTGTLLLL LQDVNDNGPT
610 620 630 640 650
PEPRSFEICS RQPEKQILSI VDKDLPPHTY PFKAALEHGS SNNWTVEIRG
660 670 680 690 700
QDELAMGLKK ELEPGEYNIF VKLTDSQGKA QVTQVKAQVC ECEGTAKNCE
710 720 730 740 750
RRSYIVGGLG VPAILGILGG ILALLILLLL LLLFARRRKV EKEPLLPPED
760 770 780 790 800
DMRDNVYNYD EEGGGEEDQD YDLSQLHRGL DARPEVIRND VAPPLMAAPQ
810 820 830 840 850
YRPRPANPDE IGNFIDENLK AADTDPTAPP YDSLLVFDYE GGGSEATSLS
860 870 880
SLNSSASDQD QDYDYLNEWG NRFKKLAELY GGGEDDE
Length:887
Mass (Da):97,755
Last modified:June 26, 2013 - v2
Checksum:i9BF63BC7389C135A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03006273 Genomic DNA. No translation available.
RefSeqiNP_001034347.2. NM_001039258.2.
UniGeneiGga.2982.

Genome annotation databases

EnsembliENSGALT00000000857; ENSGALP00000000855; ENSGALG00000000608.
GeneIDi415860.
KEGGigga:415860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03006273 Genomic DNA. No translation available.
RefSeqi NP_001034347.2. NM_001039258.2.
UniGenei Gga.2982.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000000857 ; ENSGALP00000000855 ; ENSGALG00000000608 .
GeneIDi 415860.
KEGGi gga:415860.

Organism-specific databases

CTDi 999.

Phylogenomic databases

GeneTreei ENSGT00760000118906.
KOi K05689.
OrthoDBi EOG7PS1DS.
TreeFami TF316817.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiE1C6M9_CHICK
AccessioniPrimary (citable) accession number: E1C6M9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: June 26, 2013
Last modified: October 29, 2014
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3