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E1C213 (UBP37_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 37

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene names
Name:USP37
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length986 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 3 UIM (ubiquitin-interacting motif) repeats.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 986986Ubiquitin carboxyl-terminal hydrolase 37
PRO_0000412647

Regions

Domain344 – 958615USP
Repeat712 – 73120UIM 1
Repeat813 – 83220UIM 2
Repeat835 – 85420UIM 3
Motif32 – 343KEN box 1 By similarity
Motif71 – 799D-box 1 By similarity
Motif96 – 10510D-box 2 By similarity
Motif160 – 1689D-box 3 By similarity
Motif224 – 2263KEN box 2 By similarity
Motif789 – 7913KEN box 3 By similarity

Sites

Active site3531Nucleophile By similarity
Active site9131Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
E1C213 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: A1780CFB799F5970

FASTA986110,863
        10         20         30         40         50         60 
MAPLKVHGPV RMRSMQTGIT KWKEGSFEIV EKDNKVSLVV HYNVGGIPKT FQLSHNIKSV 

        70         80         90        100        110        120 
TLRPNGRKLC CLMLTLKDTS FLTIDKVPLK DANEMRMYLD AVHQDRVHTA GKPSQGSGSF 

       130        140        150        160        170        180 
GGVLGSRTTQ KEANRQFSYI ENQAPPKRVT VESKDETPFR KVLGTPARAS VKNSSGTGAP 

       190        200        210        220        230        240 
SNRVNVAASP TSSVPHRTGL LESRSEKRKR AQPPSSEMSE DYPKENDSST NNTAMSDPAW 

       250        260        270        280        290        300 
KYLNSSREKQ LKLKQEEENR TSGVLPLQSS SYYGSRSSSK EYSTSSSTLD RSSVSSQTTS 

       310        320        330        340        350        360 
AKRSLGFLSQ PAPLSVKKMR SNQDYTGWNK PRVPLSTHPQ QQLQGFSNLG NTCYMNAILQ 

       370        380        390        400        410        420 
SLFSIQSFAN DLLKQGIPWK KIPLNALIRR FAHLLAKKDV SSPEVKKELL KKVKSAISAT 

       430        440        450        460        470        480 
AERFSGYMQN DAHEFLSQCL DQLKEDMEKL NKTWKSEPVP NDDSSPGRAS DDLSATKVYT 

       490        500        510        520        530        540 
CPVISNLEFE VQHSIICKTC GETVTKREQF NDLSIDLPRR KKLFPSRSIQ DSLDLFFRAE 

       550        560        570        580        590        600 
EIEYSCEKCN GKSAVVTHKF NRLPRVLILH LKRYSFNVAL SLNHKVGQQV VIPRYLTLLS 

       610        620        630        640        650        660 
HCTESTRLPL TLGWSAHSAI SRPLKASQMV NSCTISTSTP CRKGRFLRKE GLSELRSSTG 

       670        680        690        700        710        720 
RKNLNRVHVF KEDVQDINSS LQVQRGIRKS SKRSKMEGDK PELGNAGFDG MSEDELLAAV 

       730        740        750        760        770        780 
LEISKREASL SLSHDEDKPT SSPDTGFGDD EIQELPENLE TMETEKPKAP LESGPANFTE 

       790        800        810        820        830        840 
ITKDFDENKE NKTPEGSQGE VDWLQQYDME REREEQELQQ ALAQSLQEQE AREQKEDDDL 

       850        860        870        880        890        900 
KRATELSLQE FNSSLLDSVG SDEDSGNEDV LDMEYSEAEA EELKRNAETG ELPHSYRLIS 

       910        920        930        940        950        960 
IVSHIGSTSS SGHYISDVYD IKKQSWFTYN DLEVSRTLET TVQCDRDRSG YIFFYMHKDI 

       970        980 
FDELLETEKN AQPLSMEVGR SIRQPL 

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References

[1]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AADN02016788 Genomic DNA. No translation available.
AADN02016789 Genomic DNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7HMS09.
PhylomeDBE1C213.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTSM00726. UIM. 3 hits.
[Graphical view]
PROSITEPS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROE1C213.

Entry information

Entry nameUBP37_CHICK
AccessionPrimary (citable) accession number: E1C213
Secondary accession number(s): E1BU11
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries