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E1C213

- UBP37_CHICK

UniProt

E1C213 - UBP37_CHICK

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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

USP37

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex By similarity.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531NucleophilePROSITE-ProRule annotation
Active sitei913 – 9131Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein K11-linked deubiquitination Source: UniProtKB
  4. protein K48-linked deubiquitination Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:USP37
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 986986Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412647Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini344 – 958615USPAdd
BLAST
Repeati712 – 73120UIM 1Add
BLAST
Repeati813 – 83220UIM 2Add
BLAST
Repeati835 – 85420UIM 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 343KEN box 1By similarity
Motifi71 – 799D-box 1By similarity
Motifi96 – 10510D-box 2By similarity
Motifi160 – 1689D-box 3By similarity
Motifi224 – 2263KEN box 2By similarity
Motifi789 – 7913KEN box 3By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiE1C213.
OrthoDBiEOG7HMS09.
PhylomeDBiE1C213.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1C213-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLKVHGPV RMRSMQTGIT KWKEGSFEIV EKDNKVSLVV HYNVGGIPKT
60 70 80 90 100
FQLSHNIKSV TLRPNGRKLC CLMLTLKDTS FLTIDKVPLK DANEMRMYLD
110 120 130 140 150
AVHQDRVHTA GKPSQGSGSF GGVLGSRTTQ KEANRQFSYI ENQAPPKRVT
160 170 180 190 200
VESKDETPFR KVLGTPARAS VKNSSGTGAP SNRVNVAASP TSSVPHRTGL
210 220 230 240 250
LESRSEKRKR AQPPSSEMSE DYPKENDSST NNTAMSDPAW KYLNSSREKQ
260 270 280 290 300
LKLKQEEENR TSGVLPLQSS SYYGSRSSSK EYSTSSSTLD RSSVSSQTTS
310 320 330 340 350
AKRSLGFLSQ PAPLSVKKMR SNQDYTGWNK PRVPLSTHPQ QQLQGFSNLG
360 370 380 390 400
NTCYMNAILQ SLFSIQSFAN DLLKQGIPWK KIPLNALIRR FAHLLAKKDV
410 420 430 440 450
SSPEVKKELL KKVKSAISAT AERFSGYMQN DAHEFLSQCL DQLKEDMEKL
460 470 480 490 500
NKTWKSEPVP NDDSSPGRAS DDLSATKVYT CPVISNLEFE VQHSIICKTC
510 520 530 540 550
GETVTKREQF NDLSIDLPRR KKLFPSRSIQ DSLDLFFRAE EIEYSCEKCN
560 570 580 590 600
GKSAVVTHKF NRLPRVLILH LKRYSFNVAL SLNHKVGQQV VIPRYLTLLS
610 620 630 640 650
HCTESTRLPL TLGWSAHSAI SRPLKASQMV NSCTISTSTP CRKGRFLRKE
660 670 680 690 700
GLSELRSSTG RKNLNRVHVF KEDVQDINSS LQVQRGIRKS SKRSKMEGDK
710 720 730 740 750
PELGNAGFDG MSEDELLAAV LEISKREASL SLSHDEDKPT SSPDTGFGDD
760 770 780 790 800
EIQELPENLE TMETEKPKAP LESGPANFTE ITKDFDENKE NKTPEGSQGE
810 820 830 840 850
VDWLQQYDME REREEQELQQ ALAQSLQEQE AREQKEDDDL KRATELSLQE
860 870 880 890 900
FNSSLLDSVG SDEDSGNEDV LDMEYSEAEA EELKRNAETG ELPHSYRLIS
910 920 930 940 950
IVSHIGSTSS SGHYISDVYD IKKQSWFTYN DLEVSRTLET TVQCDRDRSG
960 970 980
YIFFYMHKDI FDELLETEKN AQPLSMEVGR SIRQPL
Length:986
Mass (Da):110,863
Last modified:November 2, 2010 - v1
Checksum:iA1780CFB799F5970
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN02016788 Genomic DNA. No translation available.
AADN02016789 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN02016788 Genomic DNA. No translation available.
AADN02016789 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi E1C213.
OrthoDBi EOG7HMS09.
PhylomeDBi E1C213.

Miscellaneous databases

PROi E1C213.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view ]
SMARTi SM00726. UIM. 3 hits.
[Graphical view ]
PROSITEi PS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP37_CHICK
AccessioniPrimary (citable) accession number: E1C213
Secondary accession number(s): E1BU11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3