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E1C1R4

- UBP47_CHICK

UniProt

E1C1R4 - UBP47_CHICK

Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

USP47

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER).By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei196 – 1961NucleophilePROSITE-ProRule annotation
    Active sitei502 – 5021Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. base-excision repair Source: UniProtKB
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. monoubiquitinated protein deubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    DNA damage, DNA repair, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 47
    Ubiquitin thioesterase 47
    Ubiquitin-specific-processing protease 47
    Gene namesi
    Name:USP47
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13751375Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408357Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 563377USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP47 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    OMAiLCEISGI.
    OrthoDBiEOG7M3HZD.
    PhylomeDBiE1C1R4.
    TreeFamiTF314142.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF14560. Ubiquitin_2. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1C1R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEFVSMRLL PEDMFWSCRQ STLAEMKKKF AQVESAAEEP RVLCIIQDTT     50
    NSKTVNERVT LNVPASTPLK KLFEDVASKV GYVNGTFDLV WGNGDNVTDM 100
    TPIDQNSDKT ILDAGFEPGK KNFLHLTDKD GEQPHIMQEE SGTTEDSAQD 150
    RFIGPLPREG SVGCTNDYVS QSYSYSSVLS KSETGYVGLV NQAMTCYLNS 200
    LLQTLFMTPE FRNALYKWEF EESEEDPVTS IPYQLQRLFV LLQTSKKRAI 250
    ETTDVTRSFG WDSSEAWQQH DVQELCRVMF DALEQKWKQT EQADLINQLY 300
    QGKLKDYVRC LECGYEGWRI DTYLDIPLVI RPYGSNQAFA SVEEALHAFI 350
    QPEILDGPNQ YFCERCKKKC DARKGLRFLH FPYLLTLQLK RFDFDYTTMH 400
    RIKLNDRMTF PEELDMSIFI DVEDEKSPQT ESCTDSGAEN EGSCHSDQMS 450
    NDFSNDDGVD EGICLESNSA AERIAKVGSE KNSLLYELFS VMVHSGSAAG 500
    GHYYACIKSF SDDQWYSFND QHVSKITQED IKKTYGGSSG SRGYYSSAFA 550
    SSTNAYMLIY RLKDPARNAK FLESHEYPDH IKQLVQKERE LEEQEKRQRE 600
    IERNTCKIKL FCMHPTKQIM MENKLEVHKD RTLKEAVGIA YKLMDLEEAV 650
    PLDCCRLVKY DEFHDYLERS YEGEEDTPMG LLLGGVKSTY MFDLLLETRR 700
    PDQIFQCYKP GEVMVKVHVV DLKTESVAPP ISVRAYLNQT VSEFKQLISK 750
    ATHLPAETMR VVLERCYNDL RLLTVSSKTL KAEGFFRSNK VFIESSESLD 800
    RHVAYTDSHL WKLLDRHANT IRLYVSLPEQ SPGSQFRRSI YQKPSGDLGN 850
    LDEACERVKG PAGNMKSVEA ILEESTEKLK SLSLQQQQQE GDNGDSSKST 900
    EASDFENIES PSNEIDSSAS VENRELENQI QISDPENLQS EERSDSDVNN 950
    DRSTSSVDSD ILSSSHSSDT LCNVDNAPIP LANGLDSHSI TSSRRSKANQ 1000
    GKKETWDTAE EDSGTDSEYD ESGKSRGETQ YMYFKSEPYT ADEGSGEGQK 1050
    WLMVHVDKRI TLSAFKQQLE PFVGVPSSHF KVFRVYASNQ EFESVRLNET 1100
    LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEPEPCKF LLDAVFAKGM 1150
    TVRQSKEELL PQLREQCGLD LTIDRFRLRK KTWKNPGTVF LDYHIYEEDI 1200
    NISSNWEVFL EILDGVEKMK SMSQLAVLSR RWRPSEMKLD SFQEVVLESS 1250
    SVEELKEKLS ELSGIPLENI EFAKGRGTFP CDISVLEIHQ DLDWNPKVST 1300
    LNVWPLYICD DGAVIFYRDK TEELMELTDE QRNELMKKES SRLQKTGHRV 1350
    TYSPRKEKAL KIYLDGAPNK DLTQD 1375
    Length:1,375
    Mass (Da):157,247
    Last modified:November 2, 2010 - v1
    Checksum:iE5929D1809146267
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN02030606 Genomic DNA. No translation available.
    AADN02030607 Genomic DNA. No translation available.
    UniGeneiGga.5374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN02030606 Genomic DNA. No translation available.
    AADN02030607 Genomic DNA. No translation available.
    UniGenei Gga.5374.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi LCEISGI.
    OrthoDBi EOG7M3HZD.
    PhylomeDBi E1C1R4.
    TreeFami TF314142.

    Miscellaneous databases

    PROi E1C1R4.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF14560. Ubiquitin_2. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUBP47_CHICK
    AccessioniPrimary (citable) accession number: E1C1R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3