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E1C1R4 (UBP47_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 47

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene names
Name:USP47
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP47 subfamily.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13751375Ubiquitin carboxyl-terminal hydrolase 47
PRO_0000408357

Regions

Domain187 – 563377USP

Sites

Active site1961Nucleophile By similarity
Active site5021Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
E1C1R4 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: E5929D1809146267

FASTA1,375157,247
        10         20         30         40         50         60 
MKEFVSMRLL PEDMFWSCRQ STLAEMKKKF AQVESAAEEP RVLCIIQDTT NSKTVNERVT 

        70         80         90        100        110        120 
LNVPASTPLK KLFEDVASKV GYVNGTFDLV WGNGDNVTDM TPIDQNSDKT ILDAGFEPGK 

       130        140        150        160        170        180 
KNFLHLTDKD GEQPHIMQEE SGTTEDSAQD RFIGPLPREG SVGCTNDYVS QSYSYSSVLS 

       190        200        210        220        230        240 
KSETGYVGLV NQAMTCYLNS LLQTLFMTPE FRNALYKWEF EESEEDPVTS IPYQLQRLFV 

       250        260        270        280        290        300 
LLQTSKKRAI ETTDVTRSFG WDSSEAWQQH DVQELCRVMF DALEQKWKQT EQADLINQLY 

       310        320        330        340        350        360 
QGKLKDYVRC LECGYEGWRI DTYLDIPLVI RPYGSNQAFA SVEEALHAFI QPEILDGPNQ 

       370        380        390        400        410        420 
YFCERCKKKC DARKGLRFLH FPYLLTLQLK RFDFDYTTMH RIKLNDRMTF PEELDMSIFI 

       430        440        450        460        470        480 
DVEDEKSPQT ESCTDSGAEN EGSCHSDQMS NDFSNDDGVD EGICLESNSA AERIAKVGSE 

       490        500        510        520        530        540 
KNSLLYELFS VMVHSGSAAG GHYYACIKSF SDDQWYSFND QHVSKITQED IKKTYGGSSG 

       550        560        570        580        590        600 
SRGYYSSAFA SSTNAYMLIY RLKDPARNAK FLESHEYPDH IKQLVQKERE LEEQEKRQRE 

       610        620        630        640        650        660 
IERNTCKIKL FCMHPTKQIM MENKLEVHKD RTLKEAVGIA YKLMDLEEAV PLDCCRLVKY 

       670        680        690        700        710        720 
DEFHDYLERS YEGEEDTPMG LLLGGVKSTY MFDLLLETRR PDQIFQCYKP GEVMVKVHVV 

       730        740        750        760        770        780 
DLKTESVAPP ISVRAYLNQT VSEFKQLISK ATHLPAETMR VVLERCYNDL RLLTVSSKTL 

       790        800        810        820        830        840 
KAEGFFRSNK VFIESSESLD RHVAYTDSHL WKLLDRHANT IRLYVSLPEQ SPGSQFRRSI 

       850        860        870        880        890        900 
YQKPSGDLGN LDEACERVKG PAGNMKSVEA ILEESTEKLK SLSLQQQQQE GDNGDSSKST 

       910        920        930        940        950        960 
EASDFENIES PSNEIDSSAS VENRELENQI QISDPENLQS EERSDSDVNN DRSTSSVDSD 

       970        980        990       1000       1010       1020 
ILSSSHSSDT LCNVDNAPIP LANGLDSHSI TSSRRSKANQ GKKETWDTAE EDSGTDSEYD 

      1030       1040       1050       1060       1070       1080 
ESGKSRGETQ YMYFKSEPYT ADEGSGEGQK WLMVHVDKRI TLSAFKQQLE PFVGVPSSHF 

      1090       1100       1110       1120       1130       1140 
KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEPEPCKF 

      1150       1160       1170       1180       1190       1200 
LLDAVFAKGM TVRQSKEELL PQLREQCGLD LTIDRFRLRK KTWKNPGTVF LDYHIYEEDI 

      1210       1220       1230       1240       1250       1260 
NISSNWEVFL EILDGVEKMK SMSQLAVLSR RWRPSEMKLD SFQEVVLESS SVEELKEKLS 

      1270       1280       1290       1300       1310       1320 
ELSGIPLENI EFAKGRGTFP CDISVLEIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK 

      1330       1340       1350       1360       1370 
TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD 

« Hide

References

[1]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AADN02030606 Genomic DNA. No translation available.
AADN02030607 Genomic DNA. No translation available.
UniGeneGga.5374.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OMALCEISGI.
OrthoDBEOG7M3HZD.
PhylomeDBE1C1R4.
TreeFamTF314142.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF14560. Ubiquitin_2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROE1C1R4.

Entry information

Entry nameUBP47_CHICK
AccessionPrimary (citable) accession number: E1C1R4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: November 2, 2010
Last modified: May 14, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries