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Protein

Alkaline phosphatase

Gene

ALPP

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMagnesiumUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-1483166 Synthesis of PA
R-GGA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-GGA-6811438 Intra-Golgi traffic
R-GGA-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:ALPPImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500314444021 – 520Alkaline phosphataseSequence analysisAdd BLAST500

Proteomic databases

PaxDbiE1C0U5

Expressioni

Gene expression databases

BgeeiENSGALG00000007814

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012662

Structurei

3D structure databases

ProteinModelPortaliE1C0U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4126 Eukaryota
COG1785 LUCA
GeneTreeiENSGT00390000008704
InParanoidiE1C0U5
KOiK01077
OMAiIDMAHHA
OrthoDBiEOG091G067H
TreeFamiTF323513

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

E1C0U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVALTLC LGLWAELGTA FIPVEEEDPS FWNRQAAAAL DATLKIEPRM
60 70 80 90 100
TEAKNLIIFL GDGFGVPSIT ATRILKGQLK GNLGPETPLA LDSFPYVALS
110 120 130 140 150
KTYTVDRAVP DSAGTATAYL CGVKGNYKTV GLSAAARYGQ CNTTKGNEVI
160 170 180 190 200
SVLERARNAG KAVGIVTTSR VQHASPSGTY AHVVDRNWYA DSSMPAEAIA
210 220 230 240 250
QGCKDIAWQL VHNVDINVIM GGGRVYMTPA GTPDPEYPEY SSENGIRNDG
260 270 280 290 300
QNLIEKWLSE RQGARYVWNR TEMLAAAADP SVTYLMGLFE PMDMKYEMVH
310 320 330 340 350
NATLDPSLTE MTEAAITILS RNPKGFYLFV EGGRIDHGHH EGMAQRALTE
360 370 380 390 400
AVEFDTAIER AGELLDEADT LTVVTADHSH VFSFGGYILR GTSILGLAPQ
410 420 430 440 450
KAIDNKTYTS ILYGNGPGYP GATRPNVSSS TAGEFNYTQQ AAVPLNSETH
460 470 480 490 500
GGEDVAILAK GPMAYLFHGV QEQNYIAHAM AYAACLEPYE NCRQRNSAAP
510 520
STHLTPLALL LPALLLSLFH
Length:520
Mass (Da):56,214
Last modified:June 26, 2013 - v2
Checksum:i7D17F9BD66BE96D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000078 Genomic DNA No translation available.
RefSeqiXP_003641809.1, XM_003641761.3

Genome annotation databases

EnsembliENSGALT00000012676; ENSGALP00000012662; ENSGALG00000007814
GeneIDi100859876
KEGGigga:100859876

Similar proteinsi

Entry informationi

Entry nameiE1C0U5_CHICK
AccessioniPrimary (citable) accession number: E1C0U5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health