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Protein

Alkaline phosphatase

Gene

ALPP

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-1483166. Synthesis of PA.
R-GGA-6811438. Intra-Golgi traffic.
R-GGA-8935690. Miscellaneous digestion events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:ALPPImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500314444021 – 520Alkaline phosphataseSequence analysisAdd BLAST500

Proteomic databases

PaxDbiE1C0U5.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012662.

Structurei

3D structure databases

ProteinModelPortaliE1C0U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4126. Eukaryota.
COG1785. LUCA.
GeneTreeiENSGT00390000008704.
InParanoidiE1C0U5.
KOiK01077.
OMAiYVGTGER.
OrthoDBiEOG091G067H.
TreeFamiTF323513.

Family and domain databases

CDDicd00016. alkPPc. 1 hit.
Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1C0U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVALTLC LGLWAELGTA FIPVEEEDPS FWNRQAAAAL DATLKIEPRM
60 70 80 90 100
TEAKNLIIFL GDGFGVPSIT ATRILKGQLK GNLGPETPLA LDSFPYVALS
110 120 130 140 150
KTYTVDRAVP DSAGTATAYL CGVKGNYKTV GLSAAARYGQ CNTTKGNEVI
160 170 180 190 200
SVLERARNAG KAVGIVTTSR VQHASPSGTY AHVVDRNWYA DSSMPAEAIA
210 220 230 240 250
QGCKDIAWQL VHNVDINVIM GGGRVYMTPA GTPDPEYPEY SSENGIRNDG
260 270 280 290 300
QNLIEKWLSE RQGARYVWNR TEMLAAAADP SVTYLMGLFE PMDMKYEMVH
310 320 330 340 350
NATLDPSLTE MTEAAITILS RNPKGFYLFV EGGRIDHGHH EGMAQRALTE
360 370 380 390 400
AVEFDTAIER AGELLDEADT LTVVTADHSH VFSFGGYILR GTSILGLAPQ
410 420 430 440 450
KAIDNKTYTS ILYGNGPGYP GATRPNVSSS TAGEFNYTQQ AAVPLNSETH
460 470 480 490 500
GGEDVAILAK GPMAYLFHGV QEQNYIAHAM AYAACLEPYE NCRQRNSAAP
510 520
STHLTPLALL LPALLLSLFH
Length:520
Mass (Da):56,214
Last modified:June 26, 2013 - v2
Checksum:i7D17F9BD66BE96D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000078 Genomic DNA. No translation available.
RefSeqiXP_003641809.1. XM_003641761.3.

Genome annotation databases

EnsembliENSGALT00000012676; ENSGALP00000012662; ENSGALG00000007814.
GeneIDi100859876.
KEGGigga:100859876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000078 Genomic DNA. No translation available.
RefSeqiXP_003641809.1. XM_003641761.3.

3D structure databases

ProteinModelPortaliE1C0U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012662.

Proteomic databases

PaxDbiE1C0U5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012676; ENSGALP00000012662; ENSGALG00000007814.
GeneIDi100859876.
KEGGigga:100859876.

Organism-specific databases

CTDi250.

Phylogenomic databases

eggNOGiKOG4126. Eukaryota.
COG1785. LUCA.
GeneTreeiENSGT00390000008704.
InParanoidiE1C0U5.
KOiK01077.
OMAiYVGTGER.
OrthoDBiEOG091G067H.
TreeFamiTF323513.

Enzyme and pathway databases

ReactomeiR-GGA-1483166. Synthesis of PA.
R-GGA-6811438. Intra-Golgi traffic.
R-GGA-8935690. Miscellaneous digestion events.

Family and domain databases

CDDicd00016. alkPPc. 1 hit.
Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE1C0U5_CHICK
AccessioniPrimary (citable) accession number: E1C0U5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: June 26, 2013
Last modified: November 30, 2016
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.