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E1BY77 (UBP13_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 13

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 13
Ubiquitin thioesterase 13
Ubiquitin-specific-processing protease 13
Gene names
Name:USP13
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme regulation

Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP13 and inhibits deubiquitinase activity By similarity.

Domain

The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin By similarity.

The UBA domains mediate binding to ubiquitin By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 2 UBA domains.

Contains 1 UBP-type zinc finger.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Ubiquitin carboxyl-terminal hydrolase 13
PRO_0000418012

Regions

Domain331 – 860530USP
Domain647 – 68842UBA 1
Domain722 – 76241UBA 2
Zinc finger204 – 27673UBP-type

Sites

Active site3401Nucleophile By similarity
Active site8221Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
E1BY77 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 9207A3B6846A1018

FASTA86296,649
        10         20         30         40         50         60 
MQRAALFGGG DAQMAAGDLG ELLVPYMPTI RVPKSGDRVY KTECAFSYDS PDSEGGLYVC 

        70         80         90        100        110        120 
MNTFLGFGRE HIERHYRKTG QCVYLHLKRH VIEKVPGASG GALPKRRNAK LFLDLEANGD 

       130        140        150        160        170        180 
LSSDDFEYED EAKLVIFPDH YEISLPNIEE LPALVTIASD ALLSAKSPYR KQDPDSWEEE 

       190        200        210        220        230        240 
LQASKHAKSL VQLDNGVRIP PSGWKCSKCD LRENLWLNLT DGSVLCGKWF FDGSGGNGHA 

       250        260        270        280        290        300 
MEHYKETGYP LAVKLGTITP DGADVYSFDE EEPVLDPHIA KHLAHFGIDM LQMQVAENGL 

       310        320        330        340        350        360 
RDNDIKPRVS EWEVIQEAGV KLKPMYGPGY TGMKNLGNSC YLNAVMQAIF SIPEFQRAYV 

       370        380        390        400        410        420 
GNLPRIFDYS PLDPTQDFNT QMAKLGHGLL SGQYSKPPMK SELIEQVMKE EHKPQQNGIS 

       430        440        450        460        470        480 
PQMFKAFISK DHTEFSSNRQ QDAQEFFLHL INLVERNPVG SENPSDVFRF LVEERTQCCQ 

       490        500        510        520        530        540 
SRKVRYTERV DYIMQLPVAM EAATNKDELI AYELKRREAE AARRAPPELV RAKIPFSACL 

       550        560        570        580        590        600 
QAFSEPTNVE DFWSSALQAK SAGVKTSRFA SFPQYLVVQI KKFTFGLDWI PKKLDVSIDM 

       610        620        630        640        650        660 
PDFLDISHLR AMGLQPGEEE LPDIAPPIII PEDPKDRMMN NFVESLDIDE SSVMQLAEMG 

       670        680        690        700        710        720 
FPLEACRKAV YYTGNLGAEV AFNWIIAHME EPDFAEPLVV PVFGGAASSG VAGLGAVGLD 

       730        740        750        760        770        780 
NQPPEEMVSI IISMGFQRSL AIQALKATNN NLERALEWIF SHPELEEEDG EPALNVMDLE 

       790        800        810        820        830        840 
NHTNANILAE ARSEGPRIKD GPGRYELFGF ISHMGTSTMS GHYVCHLKKE GRWVIYNDLR 

       850        860 
VCASERPPKD LGYIYFYHRI PS 

« Hide

References

[1]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Red jungle fowl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AADN02020803 Genomic DNA. No translation available.
AADN02020804 Genomic DNA. No translation available.
AADN02020805 Genomic DNA. No translation available.
AADN02020806 Genomic DNA. No translation available.
RefSeqXP_426842.2. XM_426842.4.

3D structure databases

ProteinModelPortalE1BY77.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000014487; ENSGALP00000014471; ENSGALG00000008909.
GeneID429286.
KEGGgga:429286.

Organism-specific databases

CTD8975.

Phylogenomic databases

GeneTreeENSGT00390000000874.
KOK11836.
OMAPQQNGIS.
OrthoDBEOG7CNZF3.
PhylomeDBE1BY77.
TreeFamTF300576.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PIRSFPIRSF016308. UBP. 1 hit.
SMARTSM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
PROSITEPS50030. UBA. 2 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20830031.
PROE1BY77.

Entry information

Entry nameUBP13_CHICK
AccessionPrimary (citable) accession number: E1BY77
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries