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Protein

Ubiquitin carboxyl-terminal hydrolase 13

Gene

USP13

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme regulationi

Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP13 and inhibits deubiquitinase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei340NucleophilePROSITE-ProRule annotation1
Active sitei822Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 276UBP-typePROSITE-ProRule annotationAdd BLAST73

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processAutophagy, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-5689880 Ub-specific processing proteases
R-GGA-8948751 Regulation of PTEN stability and activity

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 13 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 13
Ubiquitin thioesterase 13
Ubiquitin-specific-processing protease 13
Gene namesi
Name:USP13
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004180121 – 862Ubiquitin carboxyl-terminal hydrolase 13Add BLAST862

Proteomic databases

PaxDbiE1BY77
PRIDEiE1BY77

Expressioni

Gene expression databases

BgeeiENSGALG00000008909

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014471

Structurei

3D structure databases

ProteinModelPortaliE1BY77
SMRiE1BY77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 860USPAdd BLAST530
Domaini647 – 688UBA 1PROSITE-ProRule annotationAdd BLAST42
Domaini722 – 762UBA 2PROSITE-ProRule annotationAdd BLAST41

Domaini

The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin.By similarity
The UBA domains mediate binding to ubiquitin.By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 276UBP-typePROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0944 Eukaryota
COG5207 LUCA
InParanoidiE1BY77
OMAiMKEEHKP
OrthoDBiEOG091G01W3
PhylomeDBiE1BY77
TreeFamiTF300576

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR009060 UBA-like_sf
IPR016652 Ubiquitinyl_hydrolase
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00627 UBA, 2 hits
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
PIRSFiPIRSF016308 UBP, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 2 hits
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

E1BY77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAALFGGG DAQMAAGDLG ELLVPYMPTI RVPKSGDRVY KTECAFSYDS
60 70 80 90 100
PDSEGGLYVC MNTFLGFGRE HIERHYRKTG QCVYLHLKRH VIEKVPGASG
110 120 130 140 150
GALPKRRNAK LFLDLEANGD LSSDDFEYED EAKLVIFPDH YEISLPNIEE
160 170 180 190 200
LPALVTIASD ALLSAKSPYR KQDPDSWEEE LQASKHAKSL VQLDNGVRIP
210 220 230 240 250
PSGWKCSKCD LRENLWLNLT DGSVLCGKWF FDGSGGNGHA MEHYKETGYP
260 270 280 290 300
LAVKLGTITP DGADVYSFDE EEPVLDPHIA KHLAHFGIDM LQMQVAENGL
310 320 330 340 350
RDNDIKPRVS EWEVIQEAGV KLKPMYGPGY TGMKNLGNSC YLNAVMQAIF
360 370 380 390 400
SIPEFQRAYV GNLPRIFDYS PLDPTQDFNT QMAKLGHGLL SGQYSKPPMK
410 420 430 440 450
SELIEQVMKE EHKPQQNGIS PQMFKAFISK DHTEFSSNRQ QDAQEFFLHL
460 470 480 490 500
INLVERNPVG SENPSDVFRF LVEERTQCCQ SRKVRYTERV DYIMQLPVAM
510 520 530 540 550
EAATNKDELI AYELKRREAE AARRAPPELV RAKIPFSACL QAFSEPTNVE
560 570 580 590 600
DFWSSALQAK SAGVKTSRFA SFPQYLVVQI KKFTFGLDWI PKKLDVSIDM
610 620 630 640 650
PDFLDISHLR AMGLQPGEEE LPDIAPPIII PEDPKDRMMN NFVESLDIDE
660 670 680 690 700
SSVMQLAEMG FPLEACRKAV YYTGNLGAEV AFNWIIAHME EPDFAEPLVV
710 720 730 740 750
PVFGGAASSG VAGLGAVGLD NQPPEEMVSI IISMGFQRSL AIQALKATNN
760 770 780 790 800
NLERALEWIF SHPELEEEDG EPALNVMDLE NHTNANILAE ARSEGPRIKD
810 820 830 840 850
GPGRYELFGF ISHMGTSTMS GHYVCHLKKE GRWVIYNDLR VCASERPPKD
860
LGYIYFYHRI PS
Length:862
Mass (Da):96,649
Last modified:November 2, 2010 - v1
Checksum:i9207A3B6846A1018
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN02020803 Genomic DNA No translation available.
AADN02020804 Genomic DNA No translation available.
AADN02020805 Genomic DNA No translation available.
AADN02020806 Genomic DNA No translation available.
UniGeneiGga.27614

Similar proteinsi

Entry informationi

Entry nameiUBP13_CHICK
AccessioniPrimary (citable) accession number: E1BY77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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