E1BU42 (E1BU42_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase PIRNR PIRNR000604
EC=2.7.10.2 PIRNR PIRNR000604

Gene names

Name:

ZAP70 Ensembl ENSGALP00000002252

Organism

Gallus gallus (Chicken) [Reference proteome] Ensembl ENSGALP00000002252

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000604 SAAS SAAS008266
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. PIRNR PIRNR000604 Contains 1 protein kinase domain. SAAS SAAS008266
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSGALP00000002252

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008266 PIRNR PIRNR000604 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase PIRNR PIRNR000604 SAAS SAAS008266
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara beta selection Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: Compara negative thymic T cell selection Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of alpha-beta T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of calcium-mediated signaling Inferred from electronic annotation. Source: Compara positive thymic T cell selection Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	T cell receptor complex Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara immunological synapse Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E1BU42 [UniParc]. Last modified November 2, 2010. Version 1. Checksum: 5616F9FB667A5B5D	FASTA	609	69,017
	10 20 30 40 50 60 MPDAAAHLPF YYGSIARSEA EEYLKLAGMS DGLFLLRQCL RSLGGYVLSM VCNLQFYHYA 70 80 90 100 110 120 IERQMNGTYA IAGGKAHCGP EELCEFYSKD ADGLCCTLRK PCNRPSGVEP QPGVFDSMRD 130 140 150 160 170 180 NMVREYVRQT WRLEGDALEQ AIISQAPQVE KLIATTAHER MPWYHGNIAR DEAERRLYSG 190 200 210 220 230 240 AQPDGKFLLR DKKENGAYAL SLVYGKTVYH YRIDQDKSGK YSIPEGTKFD TLWQLVEYLK 250 260 270 280 290 300 LKPDGLIFYL RESCPNPSMA ASAAPAPPTH PSVSKNLGPL NADGYTPEPV AAGKSRVLPM 310 320 330 340 350 360 DTSVYESPYS DPEELKDKKL FLKRDHLMID EVELGAGNFG CVKKGVYKMR KKQIDVAIKV 370 380 390 400 410 420 LKSNNEKTVR DEMMTEAQIM HQLDNPYIVR MIGVCEAESL MLVMEMASGG PLNKFLSSKK 430 440 450 460 470 480 DEITVSNIVE LMHQVSMGMK YLEEKNFVHR DLAARNVLLV NQHYAKISDF GLSKALGADD 490 500 510 520 530 540 SYYKARTAGK WPLKWYAPEC ILYHKFSSKS DVWSYGVTMW EAFSYGQKPY KKMKGPEVIS 550 560 570 580 590 600 FIEQGKRMDC PTECPAEIYA LMMQCWTYSW EERPGFFSVE NTIRTYYYSI ATKTENGPKA EDKSKAAFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution." International Chicken Genome Sequencing Consortium Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K. Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Red jungle fowl Ensembl ENSGALP00000002252.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Red jungle fowl Ensembl ENSGALP00000002252.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AADN02072200 Genomic DNA. No translation available.
IPI	IPI00595755.
3D structure databases
ProteinModelPortal	E1BU42.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000002254; ENSGALP00000002252; ENSGALG00000001486.
Phylogenomic databases
GeneTree	ENSGT00620000087791.
OMA	PAHPSTF.
Family and domain databases
Gene3D	1.10.930.10. 1 hit. 3.30.505.10. 2 hits.
InterPro	IPR011009. Kinase-like_dom. IPR023420. Kinase_SYK/ZAP-70_inter-SH2. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR012234. Tyr_kinase_non-rcpt_SYK/ZAP70. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 2 hits. [Graphical view]
PIRSF	PIRSF000604. TyrPK_SYK. 1 hit.
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 2 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E1BU42_CHICK

Accession

Primary (citable) accession number: E1BU42

Entry history

Integrated into UniProtKB/TrEMBL:	November 2, 2010
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)