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Protein

Wee1-like protein kinase 2

Gene

WEE2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei246ATPPROSITE-ProRule annotation1
Active sitei344Proton acceptorPROSITE-ProRule annotation1
Metal bindingi349Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi383Magnesium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi223 – 231ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processMeiosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Wee1-like protein kinase 2 (EC:2.7.10.2)
Alternative name(s):
Wee1-like protein kinase 1B
Wee1B kinase
Gene namesi
Name:WEE2
Synonyms:WEE1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004095271 – 565Wee1-like protein kinase 2Add BLAST565

Proteomic databases

PaxDbiE1BTE1
PRIDEiE1BTE1

PTM databases

iPTMnetiE1BTE1

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020972

Structurei

3D structure databases

ProteinModelPortaliE1BTE1
SMRiE1BTE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 493Protein kinasePROSITE-ProRule annotationAdd BLAST277

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili496 – 522Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0601 Eukaryota
ENOG410XS1M LUCA
InParanoidiE1BTE1
PhylomeDBiE1BTE1
TreeFamiTF101088

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR017164 Wee1-like_protein_kinase
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037281 Wee1-like_protein_kinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E1BTE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDWENNDFI QRLDFSSCGE EGEDRSINEE DTLSSSPIKH CDFQKWNSPL
60 70 80 90 100
PATPHRKLSE IFLSRTKSWV SPTLKSSPGV SRTHGNAETP LHITWKKLQL
110 120 130 140 150
CDTPHTPKSL LSKTAFPSPG AKVPPKGFRH LRFTPGADLD DSTQASLVNI
160 170 180 190 200
NPFTPESYRQ MLFLPNGKRK AREIKLVHLA QSFCEKAEVQ RKDSAVRPAD
210 220 230 240 250
RCPLKDSNMV SRYQKEFLEL ERIGVGEFGS VYKCIKRLDG CVYAIKRSKR
260 270 280 290 300
PLAGSSDEQL ALREVYAHAV LGHHPHVVRY YSAWAEDDHM IIQNEHCNGG
310 320 330 340 350
SLQDVLLENA KRGQYFPEAK LKEILLQVSM GLKYIHNSGL VHLDIKPSNI
360 370 380 390 400
FICHKLVVEG QAGQEESDSD DEFSSGVMYK IGDLGHVTSI ANPQVEEGDR
410 420 430 440 450
RFLANEILQE QYFHLPKADI FALALTIALA AGAGPLPHNG AMWHHIRKGN
460 470 480 490 500
IPSIPQKLPN GFIELLKLMI HPDPMERPSA TALTKHPILR PSLGKAVQLQ
510 520 530 540 550
KQLNVEKCKT AMLERELKAA RLAQTLMKDQ PLGNANLQES ETSPKKNNKR
560
LVGGKNCRSF SFTVG
Length:565
Mass (Da):63,301
Last modified:November 2, 2010 - v1
Checksum:i65FB792814186D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN02006380 Genomic DNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiWEE2_CHICK
AccessioniPrimary (citable) accession number: E1BTE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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