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E1BQ43

- E1BQ43_CHICK

UniProt

E1BQ43 - E1BQ43_CHICK

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Protein
Submitted name: Uncharacterized protein
Gene
TTL
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741ADPImported
Binding sitei150 – 1501ADPImported
Binding sitei198 – 1981ADPImported
Metal bindingi331 – 3311MagnesiumImported
Binding sitei331 – 3311ADPImported
Metal bindingi333 – 3331MagnesiumImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1864ADPImported
Nucleotide bindingi241 – 2422ADPImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. tubulin-tyrosine ligase activity Source: Ensembl

GO - Biological processi

  1. cellular protein modification process Source: InterPro
  2. microtubule cytoskeleton organization Source: Ensembl
  3. regulation of axon extension Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

MagnesiumImported, Metal-bindingImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TTLImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I4TX-ray1.80F1-378[»]
4I50X-ray2.30F1-378[»]
4I55X-ray2.20F1-378[»]
4IHJX-ray2.00F1-378[»]
4IIJX-ray2.60F1-378[»]
4O2AX-ray2.50F1-378[»]
4O2BX-ray2.30F1-378[»]
4O4HX-ray2.10F1-378[»]
4O4IX-ray2.40F1-378[»]
4O4JX-ray2.20F1-378[»]
4O4LX-ray2.20F1-378[»]

Family & Domainsi

Sequence similaritiesi

Contains TTL domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117283.
KOiK06047.
OMAiKLYPELC.
OrthoDBiEOG72ZCDZ.
PhylomeDBiE1BQ43.
TreeFamiTF350555.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BQ43-1 [UniParc]FASTAAdd to Basket

« Hide

MYTFVVRDEN SSVYAEVSRL LLATGQWKRL RKDNPRFNLM LGERNRLPFG    50
RLGHEPGLVQ LVNYYRGADK LCRKASLVKL IKTSPELSES CTWFPESYVI 100
YPTNLKTPVA PAQNGIRHLI NNTRTDEREV FLAAYNRRRE GREGNVWIAK 150
SSAGAKGEGI LISSEASELL DFIDEQGQVH VIQKYLEKPL LLEPGHRKFD 200
IRSWVLVDHL YNIYLYREGV LRTSSEPYNS ANFQDKTCHL TNHCIQKEYS 250
KNYGRYEEGN EMFFEEFNQY LMDALNTTLE NSILLQIKHI IRSCLMCIEP 300
AISTKHLHYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI 350
VDVAISSVFP LADTGQKTSQ PTSIFIKL 378
Length:378
Mass (Da):43,496
Last modified:November 2, 2010 - v1
Checksum:i4F4734154DF09BBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03003139 Genomic DNA. No translation available.
RefSeqiNP_001186321.1. NM_001199392.2.
UniGeneiGga.14457.

Genome annotation databases

EnsembliENSGALT00000014035; ENSGALP00000014019; ENSGALG00000008614.
GeneIDi416711.
KEGGigga:416711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03003139 Genomic DNA. No translation available.
RefSeqi NP_001186321.1. NM_001199392.2.
UniGenei Gga.14457.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I4T X-ray 1.80 F 1-378 [» ]
4I50 X-ray 2.30 F 1-378 [» ]
4I55 X-ray 2.20 F 1-378 [» ]
4IHJ X-ray 2.00 F 1-378 [» ]
4IIJ X-ray 2.60 F 1-378 [» ]
4O2A X-ray 2.50 F 1-378 [» ]
4O2B X-ray 2.30 F 1-378 [» ]
4O4H X-ray 2.10 F 1-378 [» ]
4O4I X-ray 2.40 F 1-378 [» ]
4O4J X-ray 2.20 F 1-378 [» ]
4O4L X-ray 2.20 F 1-378 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000014035 ; ENSGALP00000014019 ; ENSGALG00000008614 .
GeneIDi 416711.
KEGGi gga:416711.

Organism-specific databases

CTDi 150465.

Phylogenomic databases

GeneTreei ENSGT00750000117283.
KOi K06047.
OMAi KLYPELC.
OrthoDBi EOG72ZCDZ.
PhylomeDBi E1BQ43.
TreeFami TF350555.

Miscellaneous databases

NextBioi 20820133.
PROi E1BQ43.

Family and domain databases

InterProi IPR004344. TTL/TTLL_fam.
[Graphical view ]
Pfami PF03133. TTL. 1 hit.
[Graphical view ]
PROSITEi PS51221. TTL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.
  3. "Structural basis of tubulin tyrosination by tubulin tyrosine ligase."
    Prota A.E., Magiera M.M., Kuijpers M., Bargsten K., Frey D., Wieser M., Jaussi R., Hoogenraad C.C., Kammerer R.A., Janke C., Steinmetz M.O.
    J. Cell Biol. 200:259-270(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ADP AND MAGNESIUM.
  4. "Molecular mechanism of action of microtubule-stabilizing anticancer agents."
    Prota A.E., Bargsten K., Zurwerra D., Field J.J., Diaz J.F., Altmann K.H., Steinmetz M.O.
    Science 339:587-590(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  5. "Structural basis of microtubule stabilization by laulimalide and peloruside A."
    Prota A.E., Bargsten K., Northcote P.T., Marsh M., Altmann K.H., Miller J.H., Diaz J.F., Steinmetz M.O.
    Angew. Chem. Int. Ed. 53:1621-1625(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  6. "The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization."
    Prota A.E., Danel F., Bachmann F., Bargsten K., Buey R.M., Pohlmann J., Reinelt S., Lane H., Steinmetz M.O.
    J. Mol. Biol. 426:1848-1860(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP.

Entry informationi

Entry nameiE1BQ43_CHICK
AccessioniPrimary (citable) accession number: E1BQ43
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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