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E1BQ43

- E1BQ43_CHICK

UniProt

E1BQ43 - E1BQ43_CHICK

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Protein
Submitted name:

Uncharacterized protein

Gene

TTL

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. tubulin-tyrosine ligase activity Source: Ensembl

GO - Biological processi

  1. cellular protein modification process Source: InterPro
  2. microtubule cytoskeleton organization Source: Ensembl
  3. regulation of axon extension Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

MagnesiumImported, Metal-bindingImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TTLImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I4TX-ray1.80F1-378[»]
4I50X-ray2.30F1-378[»]
4I55X-ray2.20F1-378[»]
4IHJX-ray2.00F1-378[»]
4IIJX-ray2.60F1-378[»]
4O2AX-ray2.50F1-378[»]
4O2BX-ray2.30F1-378[»]
4O4HX-ray2.10F1-378[»]
4O4IX-ray2.40F1-378[»]
4O4JX-ray2.20F1-378[»]
4O4LX-ray2.20F1-378[»]
4TUYX-ray2.10F1-378[»]
4TV8X-ray2.10F1-378[»]
4TV9X-ray2.00F1-378[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains TTL domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118951.
InParanoidiE1BQ43.
KOiK06047.
OMAiKLYPELC.
OrthoDBiEOG72ZCDZ.
PhylomeDBiE1BQ43.
TreeFamiTF350555.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BQ43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYTFVVRDEN SSVYAEVSRL LLATGQWKRL RKDNPRFNLM LGERNRLPFG
60 70 80 90 100
RLGHEPGLVQ LVNYYRGADK LCRKASLVKL IKTSPELSES CTWFPESYVI
110 120 130 140 150
YPTNLKTPVA PAQNGIRHLI NNTRTDEREV FLAAYNRRRE GREGNVWIAK
160 170 180 190 200
SSAGAKGEGI LISSEASELL DFIDEQGQVH VIQKYLEKPL LLEPGHRKFD
210 220 230 240 250
IRSWVLVDHL YNIYLYREGV LRTSSEPYNS ANFQDKTCHL TNHCIQKEYS
260 270 280 290 300
KNYGRYEEGN EMFFEEFNQY LMDALNTTLE NSILLQIKHI IRSCLMCIEP
310 320 330 340 350
AISTKHLHYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI
360 370
VDVAISSVFP LADTGQKTSQ PTSIFIKL
Length:378
Mass (Da):43,496
Last modified:November 2, 2010 - v1
Checksum:i4F4734154DF09BBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003139 Genomic DNA. No translation available.
RefSeqiNP_001186321.1. NM_001199392.2.
UniGeneiGga.14457.

Genome annotation databases

EnsembliENSGALT00000014035; ENSGALP00000014019; ENSGALG00000008614.
GeneIDi416711.
KEGGigga:416711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003139 Genomic DNA. No translation available.
RefSeqi NP_001186321.1. NM_001199392.2.
UniGenei Gga.14457.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I4T X-ray 1.80 F 1-378 [» ]
4I50 X-ray 2.30 F 1-378 [» ]
4I55 X-ray 2.20 F 1-378 [» ]
4IHJ X-ray 2.00 F 1-378 [» ]
4IIJ X-ray 2.60 F 1-378 [» ]
4O2A X-ray 2.50 F 1-378 [» ]
4O2B X-ray 2.30 F 1-378 [» ]
4O4H X-ray 2.10 F 1-378 [» ]
4O4I X-ray 2.40 F 1-378 [» ]
4O4J X-ray 2.20 F 1-378 [» ]
4O4L X-ray 2.20 F 1-378 [» ]
4TUY X-ray 2.10 F 1-378 [» ]
4TV8 X-ray 2.10 F 1-378 [» ]
4TV9 X-ray 2.00 F 1-378 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000014035 ; ENSGALP00000014019 ; ENSGALG00000008614 .
GeneIDi 416711.
KEGGi gga:416711.

Organism-specific databases

CTDi 150465.

Phylogenomic databases

GeneTreei ENSGT00760000118951.
InParanoidi E1BQ43.
KOi K06047.
OMAi KLYPELC.
OrthoDBi EOG72ZCDZ.
PhylomeDBi E1BQ43.
TreeFami TF350555.

Miscellaneous databases

NextBioi 20820133.
PROi E1BQ43.

Family and domain databases

InterProi IPR004344. TTL/TTLL_fam.
[Graphical view ]
Pfami PF03133. TTL. 1 hit.
[Graphical view ]
PROSITEi PS51221. TTL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.
  3. "Structural basis of tubulin tyrosination by tubulin tyrosine ligase."
    Prota A.E., Magiera M.M., Kuijpers M., Bargsten K., Frey D., Wieser M., Jaussi R., Hoogenraad C.C., Kammerer R.A., Janke C., Steinmetz M.O.
    J. Cell Biol. 200:259-270(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ADP AND MAGNESIUM.
  4. "Molecular mechanism of action of microtubule-stabilizing anticancer agents."
    Prota A.E., Bargsten K., Zurwerra D., Field J.J., Diaz J.F., Altmann K.H., Steinmetz M.O.
    Science 339:587-590(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH ATP ANALOG AND MAGNESIUM.
  5. "Structural basis of microtubule stabilization by laulimalide and peloruside A."
    Prota A.E., Bargsten K., Northcote P.T., Marsh M., Altmann K.H., Miller J.H., Diaz J.F., Steinmetz M.O.
    Angew. Chem. Int. Ed. 53:1621-1625(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH ATP ANALOG.
  6. "The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization."
    Prota A.E., Danel F., Bachmann F., Bargsten K., Buey R.M., Pohlmann J., Reinelt S., Lane H., Steinmetz M.O.
    J. Mol. Biol. 426:1848-1860(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP AND ATP ANALOG.
  7. "A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs."
    Prota A.E., Bargsten K., Diaz J.F., Marsh M., Cuevas C., Liniger M., Neuhaus C., Andreu J.M., Altmann K.H., Steinmetz M.O.
    Proc. Natl. Acad. Sci. U.S.A. 111:13817-13821(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ATP ANALOG.

Entry informationi

Entry nameiE1BQ43_CHICK
AccessioniPrimary (citable) accession number: E1BQ43
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3