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E1BQ43 (E1BQ43_CHICK) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains TTL domain. SAAS SAAS004344

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSGALP00000014019

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding183 – 1864ADP PDB 4O2A PDB 4IHJ
Nucleotide binding241 – 2422ADP PDB 4O2A PDB 4IHJ

Sites

Metal binding3311Magnesium PDB 4I4T PDB 4IHJ
Metal binding3331Magnesium PDB 4I4T PDB 4IHJ
Binding site741ADP PDB 4IHJ
Binding site1501ADP PDB 4IHJ
Binding site1981ADP PDB 4IHJ
Binding site3311ADP PDB 4O2A PDB 4IHJ

Sequences

Sequence LengthMass (Da)Tools
E1BQ43 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 4F4734154DF09BBD

FASTA37843,496
        10         20         30         40         50         60 
MYTFVVRDEN SSVYAEVSRL LLATGQWKRL RKDNPRFNLM LGERNRLPFG RLGHEPGLVQ 

        70         80         90        100        110        120 
LVNYYRGADK LCRKASLVKL IKTSPELSES CTWFPESYVI YPTNLKTPVA PAQNGIRHLI 

       130        140        150        160        170        180 
NNTRTDEREV FLAAYNRRRE GREGNVWIAK SSAGAKGEGI LISSEASELL DFIDEQGQVH 

       190        200        210        220        230        240 
VIQKYLEKPL LLEPGHRKFD IRSWVLVDHL YNIYLYREGV LRTSSEPYNS ANFQDKTCHL 

       250        260        270        280        290        300 
TNHCIQKEYS KNYGRYEEGN EMFFEEFNQY LMDALNTTLE NSILLQIKHI IRSCLMCIEP 

       310        320        330        340        350        360 
AISTKHLHYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI VDVAISSVFP 

       370 
LADTGQKTSQ PTSIFIKL 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
International Chicken Genome Sequencing Consortium
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Red jungle fowl Ensembl ENSGALP00000014019.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Red jungle fowl Ensembl ENSGALP00000014019.
[3]"Structural basis of tubulin tyrosination by tubulin tyrosine ligase."
Prota A.E., Magiera M.M., Kuijpers M., Bargsten K., Frey D., Wieser M., Jaussi R., Hoogenraad C.C., Kammerer R.A., Janke C., Steinmetz M.O.
J. Cell Biol. 200:259-270(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ADP AND MAGNESIUM.
[4]"Molecular mechanism of action of microtubule-stabilizing anticancer agents."
Prota A.E., Bargsten K., Zurwerra D., Field J.J., Diaz J.F., Altmann K.H., Steinmetz M.O.
Science 339:587-590(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
[5]"Structural basis of microtubule stabilization by laulimalide and peloruside A."
Prota A.E., Bargsten K., Northcote P.T., Marsh M., Altmann K.H., Miller J.H., Diaz J.F., Steinmetz M.O.
Angew. Chem. Int. Ed. 53:1621-1625(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
[6]"The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization."
Prota A.E., Danel F., Bachmann F., Bargsten K., Buey R.M., Pohlmann J., Reinelt S., Lane H., Steinmetz M.O.
J. Mol. Biol. 426:1848-1860(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AADN03003139 Genomic DNA. No translation available.
RefSeqNP_001186321.1. NM_001199392.2.
UniGeneGga.14457.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4I4TX-ray1.80F1-378[»]
4I50X-ray2.30F1-378[»]
4I55X-ray2.20F1-378[»]
4IHJX-ray2.00F1-378[»]
4IIJX-ray2.60F1-378[»]
4O2AX-ray2.50F1-378[»]
4O2BX-ray2.30F1-378[»]
4O4HX-ray2.10F1-378[»]
4O4IX-ray2.40F1-378[»]
4O4JX-ray2.20F1-378[»]
4O4LX-ray2.20F1-378[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000014035; ENSGALP00000014019; ENSGALG00000008614.
GeneID416711.
KEGGgga:416711.

Organism-specific databases

CTD150465.

Phylogenomic databases

GeneTreeENSGT00750000117283.
KOK06047.
OMAKLYPELC.
OrthoDBEOG72ZCDZ.
PhylomeDBE1BQ43.
TreeFamTF350555.

Family and domain databases

InterProIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamPF03133. TTL. 1 hit.
[Graphical view]
PROSITEPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20820133.
PROE1BQ43.

Entry information

Entry nameE1BQ43_CHICK
AccessionPrimary (citable) accession number: E1BQ43
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)