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Protein

Palmitoyltransferase ZDHHC5

Gene

ZDHHC5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5 and FLOT2.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC5 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 5
Short name:
DHHC-5
Gene namesi
Name:ZDHHC5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 15, Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 52ExtracellularSequence analysisAdd BLAST18
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 148CytoplasmicSequence analysisAdd BLAST75
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 191ExtracellularSequence analysisAdd BLAST22
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 714CytoplasmicSequence analysisAdd BLAST502

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004183631 – 714Palmitoyltransferase ZDHHC5Add BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphotyrosineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei294PhosphothreonineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei303PhosphothreonineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei348PhosphothreonineBy similarity1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei411PhosphothreonineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Modified residuei429PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei529PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei616Omega-N-methylarginineBy similarity1
Modified residuei620PhosphoserineBy similarity1
Modified residuei658PhosphothreonineBy similarity1
Modified residuei693PhosphoserineBy similarity1
Modified residuei696Omega-N-methylarginineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiE1BLT8.
PRIDEiE1BLT8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002381.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003078.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
InParanoidiE1BLT8.
KOiK20030.
OMAiVPTGPTH.
OrthoDBiEOG091G02XW.
TreeFamiTF354263.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

E1BLT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAESAKRFK PSKYVPVSAA AIFLVGATTL FFAFTCPGLS LSVSPAVPVY
60 70 80 90 100
NAVVFLFVLA NFSMATFMDP GVFPRAEEDE DKEDDFRAPL YKTVEIKGIQ
110 120 130 140 150
VRMKWCATCR FYRPPRCSHC SVCDNCVEEF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLTAHI TGVFGFGLLY VLYHMEELSG VRTAVTMAVM CVAGLFFIPV
210 220 230 240 250
AGLTGFHVVL VARGRTTNEQ VTGKFRGGVN PFTNGCCNNV SRVLCSSPAP
260 270 280 290 300
RYLGRPKKEK TIVIRPPFLR PEVSDGQITV KIMDNGIQGE LRRTKSKGSL
310 320 330 340 350
EVTESQSADA EPPPPPKPDL SRYTGLRTHL SLATNEESSL LGKDSPPTPT
360 370 380 390 400
MYKYRPGYSS SSASAAMPHS SSAKLSRGDS LKEPPSIAES SRQPSYRSEP
410 420 430 440 450
SLEPESFRSP TLGKGFPFDP LSSGSRSSSL KSAQGTGFEL GPLQSIRSEG
460 470 480 490 500
TTSTSYKSLA NQTRNGSLSY DSLLTPSDSP DFESVQAGPE PEPPLGYTSP
510 520 530 540 550
FLSARLAQQR EAERHPRLAP GGPAPREPSP VRYDNLSRHI VASLQEREKL
560 570 580 590 600
LRQSPPPGRE EEPGLGDSGV QCTPGSGHAP RTSSSSDDSK RSPLGKTPLA
610 620 630 640 650
RPVAPRFGKP DGLRGRGLAS PEPGLPAPYL GRSVSYSSQK APPGVPETEE
660 670 680 690 700
VALQPLLTPK DEVQLKTAYS KSNGQPKSIG SAPPGPGQPP LSSPTRGGVK
710
KVSGVGGTTY EISV
Length:714
Mass (Da):76,976
Last modified:November 2, 2010 - v1
Checksum:iF86040EEF7BFE613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02041769 Genomic DNA. No translation available.
RefSeqiNP_001179692.1. NM_001192763.1.
XP_005201016.1. XM_005200959.2.
UniGeneiBt.30828.

Genome annotation databases

EnsembliENSBTAT00000003078; ENSBTAP00000003078; ENSBTAG00000002381.
GeneIDi533250.
KEGGibta:533250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02041769 Genomic DNA. No translation available.
RefSeqiNP_001179692.1. NM_001192763.1.
XP_005201016.1. XM_005200959.2.
UniGeneiBt.30828.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003078.

Proteomic databases

PaxDbiE1BLT8.
PRIDEiE1BLT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003078; ENSBTAP00000003078; ENSBTAG00000002381.
GeneIDi533250.
KEGGibta:533250.

Organism-specific databases

CTDi25921.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
InParanoidiE1BLT8.
KOiK20030.
OMAiVPTGPTH.
OrthoDBiEOG091G02XW.
TreeFamiTF354263.

Gene expression databases

BgeeiENSBTAG00000002381.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC5_BOVIN
AccessioniPrimary (citable) accession number: E1BLT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: November 2, 2010
Last modified: March 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.