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Protein
Submitted name:

Desmoplakin

Gene

DSP

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.
R-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Submitted name:
DesmoplakinImported
Gene namesi
Name:DSPImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE1BKT9.
PRIDEiE1BKT9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015106.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020103.

Structurei

3D structure databases

ProteinModelPortaliE1BKT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 165Sequence analysisAdd BLAST21
Coiled coili329 – 349Sequence analysisAdd BLAST21
Coiled coili421 – 451Sequence analysisAdd BLAST31
Coiled coili719 – 739Sequence analysisAdd BLAST21
Coiled coili1037 – 1057Sequence analysisAdd BLAST21
Coiled coili1065 – 1106Sequence analysisAdd BLAST42
Coiled coili1114 – 1162Sequence analysisAdd BLAST49
Coiled coili1181 – 1219Sequence analysisAdd BLAST39
Coiled coili1235 – 1283Sequence analysisAdd BLAST49
Coiled coili1316 – 1357Sequence analysisAdd BLAST42
Coiled coili1405 – 1446Sequence analysisAdd BLAST42
Coiled coili1454 – 1474Sequence analysisAdd BLAST21
Coiled coili1479 – 1530Sequence analysisAdd BLAST52
Coiled coili1538 – 1558Sequence analysisAdd BLAST21
Coiled coili1566 – 1691Sequence analysisAdd BLAST126
Coiled coili1699 – 1754Sequence analysisAdd BLAST56
Coiled coili1773 – 1814Sequence analysisAdd BLAST42
Coiled coili1822 – 1929Sequence analysisAdd BLAST108

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IQBR. Eukaryota.
ENOG4111ACS. LUCA.
GeneTreeiENSGT00760000119163.
InParanoidiE1BKT9.
KOiK10381.
OMAiKRSMSFQ.
OrthoDBiEOG091G003R.
TreeFamiTF106435.

Family and domain databases

Gene3Di3.90.1290.10. 4 hits.
InterProiView protein in InterPro
IPR028462. Desmoplakin.
IPR035915. Plakin_repeat_sf.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
PANTHERiPTHR44773. PTHR44773. 1 hit.
PfamiView protein in Pfam
PF00681. Plectin. 8 hits.
SMARTiView protein in SMART
SM00250. PLEC. 18 hits.
SM00150. SPEC. 3 hits.
SUPFAMiSSF75399. SSF75399. 5 hits.

Sequencei

Sequence statusi: Complete.

E1BKT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TCGGVGGGGG GGGGGGTSRM
60 70 80 90 100
YYSRRCTVTD QNSDGYGQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ
110 120 130 140 150
PELKYGDGIQ LARSRELDEC FAQANDQMEI TDSLIREMRQ MGQPCDAYQK
160 170 180 190 200
RLLQLQEQMR ALYKAISGPR VRRASSKGGG GYTCQSGSGW DEFTKRLTSE
210 220 230 240 250
CLGWMRQQRA EMDMMTWGVD LASVEQHISS HRSIHNTIGD YRWQLDKIKA
260 270 280 290 300
DLREKSAIYQ LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE
310 320 330 340 350
EEELLYDWSD RNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ
360 370 380 390 400
HPASDKIEAY MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA
410 420 430 440 450
YLKGLQDSIR KKYPCDKNTP LQRLLEQIKE LEKEREKILE YKRQVQSLVN
460 470 480 490 500
KSKKIVQLKP RNPDYRSNKP IILRALCDYK QDQKIVHKGD ECILKDNNER
510 520 530 540 550
SKWYVTGPGG VDMLVPSVGL IIPPPNPLAV DLSSKIEQYY EAILALWNQL
560 570 580 590 600
YINMKSLVSW HYCMIDIEKI KAMTIAKLKT MRQEDYMKTI SDLELHYQEF
610 620 630 640 650
IRNSQGSEMF GDDDKRKMQT QFTDAQKHYQ TLVIQLPGHP QHQTVTTTEI
660 670 680 690 700
THLGTCQDVN HNKVIETNRE NDKQEAWMLI ELQKIRRQME LCESRMALKN
710 720 730 740 750
ILLADQGSSH HITVKINELK SVQNDAQAIA QVLNQLKDML ANFRGSEKYC
760 770 780 790 800
YLQNEVFGLF QKLENINGVT DGYLNSLCAV RALLQAILQT EDMLKVYEAR
810 820 830 840 850
LTEEETVCLD LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS
860 870 880 890 900
QTSQQYPLYD LDLGKFSEKV TQLTDRWQRI DKQIDYRLWD LEKQIKQLRN
910 920 930 940 950
YRDNYQTFCK WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK
960 970 980 990 1000
RDKSEEVQKI AELCANSIKD YELQLASYTS GLETLLSIPI KRTVIQSPSG
1010 1020 1030 1040 1050
VILQEAADMH ARYIELLTRS GDYYRFLSEM LKSLEDLKLK NTKIEVLEEE
1060 1070 1080 1090 1100
LRLARDANSE NCNKNKFLDQ NLQKYQAECS QFKAKLVSLE ELKRQAELDG
1110 1120 1130 1140 1150
KSAKQNLDKC YGQIKELNEK ITRLTYEIED EKRRRKAVED RFDQQKSDYD
1160 1170 1180 1190 1200
QLQKARQNEK ESLGWQKMES EKAIKEKEFE IERLRVLLQE EGARKREYEN
1210 1220 1230 1240 1250
ELAKVRNHYN EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD
1260 1270 1280 1290 1300
RLSRENRDLK EEIVRLNDSI LQTTEQRRRA EEDALQQKAC GSEVLQKKQY
1310 1320 1330 1340 1350
LEIELKQVIQ QRSEDNARHK QSLEEAAKTI QDKNKEIERL KTEFQEEAKR
1360 1370 1380 1390 1400
RWEYENELAK VRANYDEEII SLKNQFETEI NITKTTIHQL TLQKEEDTSG
1410 1420 1430 1440 1450
YRAQIDTLTR ENRSLSEEVK RLKNTLAQNT ETLRRVEENV QQQKATGLEM
1460 1470 1480 1490 1500
SQRKQQLEVE LRQVTQMRTE ESARYKQSLD DAAKTIQDKN KEIDRLKQLI
1510 1520 1530 1540 1550
ETEASQRKCL EDENARLQRA QGELQKAHSS ATETISKLKV QEQELLRLRL
1560 1570 1580 1590 1600
DYERVSQERT VRDQDIARFQ TSLKELQLQK QKAEEELARL KRAASEDSSK
1610 1620 1630 1640 1650
RKKLEEELEG MRRTLKEQAI KVTSLTQQLE QASIVKKRSE DELRQQRDTL
1660 1670 1680 1690 1700
DGHLREKQRT QDELRRLASE VEALRRQLLQ EQESVRQAQT RNEHFQKAIE
1710 1720 1730 1740 1750
DKSRSLNESK IEIERLQSLT ESLTKEHLML EEELRQLRLE YDDLQRGRSE
1760 1770 1780 1790 1800
ADHDKNATIA ELRNQLQISN NRTLELQGLI NDLQRERENL RQEIERFQKQ
1810 1820 1830 1840 1850
ALEASNRIQE SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEEELSRAK
1860 1870 1880 1890 1900
TTLEAESRLK QRLECEKQQI QNDLNQWKTQ YSRKEEAIRK IESEREKSER
1910 1920 1930 1940 1950
EKNSLRSEIE RLQAEIKRIE ERCRRKLEDS SRETQSQLET ERCRLQREID
1960 1970 1980 1990 2000
RLKQRPYGSH RETQTEYEWS VDSSKLVFDG LRKKVTAMQL YECQLIDKAT
2010 2020 2030 2040 2050
LDKLLKGKKS VEEVASEIQP FLRGAGAIAG ASASPKEKYS LVEAKRKKLI
2060 2070 2080 2090 2100
TPESTVMLLE AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYTAE
2110 2120 2130 2140 2150
KAITGFDDPF SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS
2160 2170 2180 2190 2200
VFLPKDVALA RGLIDRDLYR SLNDPRDSQK NFVDPVTKKK VSYMQLRERC
2210 2220 2230 2240 2250
RIEPHTGLLL LSVQKRSMSF QGIRQPVTVS ELVDSGILRP STVNELESGQ
2260 2270 2280 2290 2300
ISYDEVGERI KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI GLVRPGTALE
2310 2320 2330 2340 2350
LLEAQAATGF IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN
2360 2370 2380 2390 2400
DPETGNIISL FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI
2410 2420 2430 2440 2450
AYKRGYFNEE LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG
2460 2470 2480 2490 2500
LCLLPLKEKK KQVQTSQKNT LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY
2510 2520 2530 2540 2550
DTFKELCEQE CEWEEITITG SDGSTRVVLV DRKTGSQYDI QDTIDKGLID
2560 2570 2580 2590 2600
RKFFEQYRSG SLSLTQFADM ISLKNGVGGG VGGIVGGGSS TGGGLSDDVF
2610 2620 2630 2640 2650
GSSRHETVSK ISTISSIKNL TIRSSSLSEP LEESSPIAAI FDTENLEKIS
2660 2670 2680 2690 2700
ISEGIERGIV DSISGQRLLE AQACTGGIIH PTTGQKLSLQ DAVSQGLIDQ
2710 2720 2730 2740 2750
DMATRLKPAQ KAFIGFEGVK GKKKMSAAEA VKEKWLPYEA GQRFLEFQYL
2760 2770 2780 2790 2800
TGGLVDPEVQ GRISTEEAIR KGYIDGRAAQ RLQDTSTYGK ILTCPKTKLK
2810 2820 2830 2840 2850
ISYKDAINRS MVEDVTGLRL LEAASVSSKG LPSPYNMSSA PGSRSGSRSG
2860 2870 2880
SRSGSRSGSR SGSRRGSFDA TGNSSYSYCY SFSSSSIGH
Length:2,889
Mass (Da):332,383
Last modified:November 2, 2010 - v1
Checksum:i5631A9C2F4AE2570
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055811 Genomic DNA. No translation available.
RefSeqiNP_001179297.1. NM_001192368.1.

Genome annotation databases

EnsembliENSBTAT00000020103; ENSBTAP00000020103; ENSBTAG00000015106.
GeneIDi514360.
KEGGibta:514360.

Similar proteinsi

Entry informationi

Entry nameiE1BKT9_BOVIN
AccessioniPrimary (citable) accession number: E1BKT9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: December 20, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported