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E1BKN0

- E1BKN0_BOVIN

UniProt

E1BKN0 - E1BKN0_BOVIN

Protein
Submitted name:

Uncharacterized protein

Gene

KMT2B

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. histone methyltransferase activity (H3-K4 specific) Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gene silencing Source: Ensembl
    2. histone H3-K4 trimethylation Source: Ensembl
    3. oocyte differentiation Source: Ensembl
    4. ovarian follicle development Source: Ensembl
    5. ovulation Source: Ensembl
    6. regulation of histone H3-K4 methylation Source: Ensembl

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:KMT2BImported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. histone methyltransferase complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115089.
    KOiK14959.
    OMAiWTSLTRE.
    OrthoDBiEOG73RBBN.
    TreeFamiTF319820.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR003889. FYrich_C.
    IPR003888. FYrich_N.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR002857. Znf_CXXC.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF05965. FYRC. 1 hit.
    PF05964. FYRN. 1 hit.
    PF00628. PHD. 2 hits.
    PF00856. SET. 1 hit.
    PF02008. zf-CXXC. 1 hit.
    [Graphical view]
    SMARTiSM00384. AT_hook. 5 hits.
    SM00542. FYRC. 1 hit.
    SM00541. FYRN. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 2 hits.
    PROSITEiPS51543. FYRC. 1 hit.
    PS51542. FYRN. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS51058. ZF_CXXC. 1 hit.
    PS50016. ZF_PHD_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1BKN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGNGA ERVRVALRRG     50
    GGAAGPGGAE PGEDTALLRL LGLHRGLRRL RRLWAGPRIQ RGRGRGRGRG 100
    WGPSRGCLLE EESSDGESDD EEFQGFHSDE DAASSSLRSA LRSQRGRAPR 150
    GRGRKHKTTP LPPPRLADVA PAPPKTPARK RGEEGTERMV QALTELLRRA 200
    QAPPAPRSRA CESSTPRRSR GRPPGRPAGP CRKKQQAVVV AEAAVTIPRP 250
    EPPPPVVPVK HRTGSWKCKE GPGPGPGTPK RGGQSGRGGR GGRGRGRGRL 300
    PLVIKFVSKA KKMKMGQLSL GLESGQGQDQ HEESWQDAPQ GRVGSGQGEG 350
    PCWRKEQKLE EEGEEEKEEE DEEEERAVAE EAMVLAEEKE EAKLPSPPLT 400
    PPAPPPPPSL PPASASPPSP LCPPPPPVSP PPPPTPPPPR APEEQEESPP 450
    PVVPATCSRK RGRPPLTPSQ RAEREAARAG PEGTSPPTPV PSTATGGPLE 500
    DSPTVAPKST TFLKNIRQFI MPVVSARSSR VIKTPRRFMD EDPPKPPKVE 550
    VSPTLRPPIA TSPLAPQEPA PAPSPPRAPT PPSTPVPLPE KRRSILREPT 600
    FRWTSLTREL PPPPPAPPPA PPPLPAPVTP SRRPLLLRAP QFTPSEAHLK 650
    IYESVLTTPP LGAPEAPEPE PPPADDSPAE PEPRALGRTN HLSLPRFAPV 700
    VATPIKAEMP SPGAPAPSSG QQPHAQLQQP LQALQTQLLP PALPPQQSLL 750
    QPQLQLQPPP QQAPPLEKAR IAGLGSLPLS GVEEKMFSLL KRAKVQLIKI 800
    DQQQQQKVAS LMPPSPGGQM EEVVGTVKQI PDRGSVKSED ESVETKRERP 850
    SGPESPVQGP RIKHVCRHAA VALGQARAMV PEDVPRLSAL PLRDRQDLNA 900
    EDTSSASETE SVPSQSQPGK VESTGPGGDS EPAGSGGTLA HAPRRSLPSH 950
    HGKKMRMARC GHCRGCLRVQ DCGSCVNCLD KPKFGGPNTK KQCCVYRKCD 1000
    KIEARKMERL AKKGRTIVKT LLPWDSDESP EASPGPPGPR RGAGAGGPRE 1050
    EVVAPPGPEE QDSFLLQRKS ARRCVKQRPS YDIFEDSDDS DPGGPPAPRR 1100
    RTPRENELPV PEPEEQSRPR KPTLQPVLQL KARRRLDKDA LAPGPFASFP 1150
    NGWTGKQKSP DGVHRVRVDF KEDCDLENVW LMGGLSVLTS VPGGPPMVCL 1200
    LCASKGLHEL VFCQVCCDPF HPFCLEEAER PLPQHHDTWC CRRCKFCHVC 1250
    GRKGRGSKHL LECERCRHAY HPACLGPSYP TRATRKRRHW ICSACVRCKS 1300
    CGATPGKNWD VEWSGDYSLC PRCTQLFEKG NYCPICTRCY EDNDYESKMM 1350
    QCAQCDHWVH AKCEGLSDED YEILSGLPDS VLYTCGPCAG ATHPRWREAL 1400
    SGALQGGLRQ VLQGLLSSKV AGPLLLCTQC GQEGQQLHPG PCDLHAVRRR 1450
    FEEGHYKSVH SFMEDVVGIL MRHSEEGEML ERRAGGQTKG LLLKLLESAF 1500
    GWFDAHDPKY WRRSTRLPNG VLPNAVLPPS LDHVYAQWRQ QEPETPESGQ 1550
    PPGDPSTAFQ GKDSAAFSHL EDPRQCALCL KYGDADSKEA GRLLYIGQNE 1600
    WTHVNCAIWS AEVFEENDGS LKNVHAAVAR GRQMRCELCL KPGATVGCCL 1650
    SSCLSNFHFM CARASYCIFQ DDKKVFCQKH TDLLDGKEIV NPDGFDVLRR 1700
    VYVDFEGINF KRKFLTGLEP DAINVLIGSI RIDSLGTLSD LSDCEGRLFP 1750
    IGYQCSRLYW STVDARRRCW YRCRILEYRP WGPREEPVHL EAAEENQTIV 1800
    HSPAPCSEPP DHVDPPPDTD ALIPRAPEHH PPVQNPDPPP RLDPSSAPPP 1850
    APRSFSGARI KVPNYSPSRR PLGGVSFGPL PSPGSPSSLT HHIPTVGDPD 1900
    FPAPPRRSRR PSPLASRLPP SRRASPPLRT SPQLRVPPPT SVVRALTPTS 1950
    GELAPPSRAP SPPPPPEDLG PDFEDMEVVS GLSAADLDFA ASLLGTEPFQ 2000
    EEIVAAGAGG SSHGGLGDSS EEEAGPTPRY VHFPVTVVSG PALAPGALPG 2050
    APRIEQLDGV DDGTDSEAEA VQQPRGQGTP TSGPGAGRAG VIGAAGDRAR 2100
    PPEDLPSEIV DFVLKNLGGP GEGGAGPREE PLPPAPPLAN GSQPPQGLPP 2150
    NPADPTRTFA WLPGPPGVRV LSLGPAPEPP KPAASKIILV NKLGQVFVKM 2200
    AGEGEPVSPP VKPPPLPPPM PPTAPTSWTL PPGPLLGVLP VVGVVRPAPP 2250
    PPPPPLTLVL SSGPPSPPRQ AIRVKRVSTF SGRSPPAPPP SKTPRLEEDG 2300
    ESLEDPPQGP GPCGSGFSRV RMKTPTVRGV LDLDDSGELT AEESPRPLQD 2350
    RSPLLPLPEG GPPRAPDGPP DLLLESQWHH YSGEASSSEE EPPSPEDKEN 2400
    QAPKRAGPHL RFEISSEDGF SVEAESLEGA WRTLIEKVQE ARGHARLRHL 2450
    SFSGMSGARL LGIHHDAVIF LAEQLPGAQR CQHYKFRYHQ QGEGQEEPPL 2500
    NPHGAARAEV YLRKCTFDMF NFLASQHRVL PEGATCDEEE DEVQLRSTRR 2550
    ATSLELPMAM RFRHLKKTSK EAVGVYRSAI HGRGLFCKRN IDAGEMVIEY 2600
    SGIVIRSVLT DKREKFYDGK GIGCYMFRMD DFDVVDATMH GNAARFINHS 2650
    CEPNCFSRVI HVEGQKHIVI FALRRILRGE ELTYDYKFPI EDASNKLPCN 2700
    CGAKRCRRFL N 2711
    Length:2,711
    Mass (Da):293,366
    Last modified:November 16, 2011 - v2
    Checksum:iBED4A79F7DA60E24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02046952 Genomic DNA. No translation available.
    RefSeqiXP_003587289.1. XM_003587241.2.

    Genome annotation databases

    EnsembliENSBTAT00000003584; ENSBTAP00000003584; ENSBTAG00000002763.
    GeneIDi785776.
    KEGGibta:785776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02046952 Genomic DNA. No translation available.
    RefSeqi XP_003587289.1. XM_003587241.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000003584 ; ENSBTAP00000003584 ; ENSBTAG00000002763 .
    GeneIDi 785776.
    KEGGi bta:785776.

    Organism-specific databases

    CTDi 9757.

    Phylogenomic databases

    GeneTreei ENSGT00740000115089.
    KOi K14959.
    OMAi WTSLTRE.
    OrthoDBi EOG73RBBN.
    TreeFami TF319820.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR003889. FYrich_C.
    IPR003888. FYrich_N.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR002857. Znf_CXXC.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF05965. FYRC. 1 hit.
    PF05964. FYRN. 1 hit.
    PF00628. PHD. 2 hits.
    PF00856. SET. 1 hit.
    PF02008. zf-CXXC. 1 hit.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 5 hits.
    SM00542. FYRC. 1 hit.
    SM00541. FYRN. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 2 hits.
    PROSITEi PS51543. FYRC. 1 hit.
    PS51542. FYRN. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS51058. ZF_CXXC. 1 hit.
    PS50016. ZF_PHD_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiE1BKN0_BOVIN
    AccessioniPrimary (citable) accession number: E1BKN0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3