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Protein

Histone-lysine N-methyltransferase

Gene

KMT2B

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:KMT2BImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003584.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119228.
InParanoidiE1BKN0.
KOiK14959.
OMAiWTSLTRE.
OrthoDBiEOG73RBBN.
TreeFamiTF319820.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 5 hits.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS51058. ZF_CXXC. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BKN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGNGA ERVRVALRRG
60 70 80 90 100
GGAAGPGGAE PGEDTALLRL LGLHRGLRRL RRLWAGPRIQ RGRGRGRGRG
110 120 130 140 150
WGPSRGCLLE EESSDGESDD EEFQGFHSDE DAASSSLRSA LRSQRGRAPR
160 170 180 190 200
GRGRKHKTTP LPPPRLADVA PAPPKTPARK RGEEGTERMV QALTELLRRA
210 220 230 240 250
QAPPAPRSRA CESSTPRRSR GRPPGRPAGP CRKKQQAVVV AEAAVTIPRP
260 270 280 290 300
EPPPPVVPVK HRTGSWKCKE GPGPGPGTPK RGGQSGRGGR GGRGRGRGRL
310 320 330 340 350
PLVIKFVSKA KKMKMGQLSL GLESGQGQDQ HEESWQDAPQ GRVGSGQGEG
360 370 380 390 400
PCWRKEQKLE EEGEEEKEEE DEEEERAVAE EAMVLAEEKE EAKLPSPPLT
410 420 430 440 450
PPAPPPPPSL PPASASPPSP LCPPPPPVSP PPPPTPPPPR APEEQEESPP
460 470 480 490 500
PVVPATCSRK RGRPPLTPSQ RAEREAARAG PEGTSPPTPV PSTATGGPLE
510 520 530 540 550
DSPTVAPKST TFLKNIRQFI MPVVSARSSR VIKTPRRFMD EDPPKPPKVE
560 570 580 590 600
VSPTLRPPIA TSPLAPQEPA PAPSPPRAPT PPSTPVPLPE KRRSILREPT
610 620 630 640 650
FRWTSLTREL PPPPPAPPPA PPPLPAPVTP SRRPLLLRAP QFTPSEAHLK
660 670 680 690 700
IYESVLTTPP LGAPEAPEPE PPPADDSPAE PEPRALGRTN HLSLPRFAPV
710 720 730 740 750
VATPIKAEMP SPGAPAPSSG QQPHAQLQQP LQALQTQLLP PALPPQQSLL
760 770 780 790 800
QPQLQLQPPP QQAPPLEKAR IAGLGSLPLS GVEEKMFSLL KRAKVQLIKI
810 820 830 840 850
DQQQQQKVAS LMPPSPGGQM EEVVGTVKQI PDRGSVKSED ESVETKRERP
860 870 880 890 900
SGPESPVQGP RIKHVCRHAA VALGQARAMV PEDVPRLSAL PLRDRQDLNA
910 920 930 940 950
EDTSSASETE SVPSQSQPGK VESTGPGGDS EPAGSGGTLA HAPRRSLPSH
960 970 980 990 1000
HGKKMRMARC GHCRGCLRVQ DCGSCVNCLD KPKFGGPNTK KQCCVYRKCD
1010 1020 1030 1040 1050
KIEARKMERL AKKGRTIVKT LLPWDSDESP EASPGPPGPR RGAGAGGPRE
1060 1070 1080 1090 1100
EVVAPPGPEE QDSFLLQRKS ARRCVKQRPS YDIFEDSDDS DPGGPPAPRR
1110 1120 1130 1140 1150
RTPRENELPV PEPEEQSRPR KPTLQPVLQL KARRRLDKDA LAPGPFASFP
1160 1170 1180 1190 1200
NGWTGKQKSP DGVHRVRVDF KEDCDLENVW LMGGLSVLTS VPGGPPMVCL
1210 1220 1230 1240 1250
LCASKGLHEL VFCQVCCDPF HPFCLEEAER PLPQHHDTWC CRRCKFCHVC
1260 1270 1280 1290 1300
GRKGRGSKHL LECERCRHAY HPACLGPSYP TRATRKRRHW ICSACVRCKS
1310 1320 1330 1340 1350
CGATPGKNWD VEWSGDYSLC PRCTQLFEKG NYCPICTRCY EDNDYESKMM
1360 1370 1380 1390 1400
QCAQCDHWVH AKCEGLSDED YEILSGLPDS VLYTCGPCAG ATHPRWREAL
1410 1420 1430 1440 1450
SGALQGGLRQ VLQGLLSSKV AGPLLLCTQC GQEGQQLHPG PCDLHAVRRR
1460 1470 1480 1490 1500
FEEGHYKSVH SFMEDVVGIL MRHSEEGEML ERRAGGQTKG LLLKLLESAF
1510 1520 1530 1540 1550
GWFDAHDPKY WRRSTRLPNG VLPNAVLPPS LDHVYAQWRQ QEPETPESGQ
1560 1570 1580 1590 1600
PPGDPSTAFQ GKDSAAFSHL EDPRQCALCL KYGDADSKEA GRLLYIGQNE
1610 1620 1630 1640 1650
WTHVNCAIWS AEVFEENDGS LKNVHAAVAR GRQMRCELCL KPGATVGCCL
1660 1670 1680 1690 1700
SSCLSNFHFM CARASYCIFQ DDKKVFCQKH TDLLDGKEIV NPDGFDVLRR
1710 1720 1730 1740 1750
VYVDFEGINF KRKFLTGLEP DAINVLIGSI RIDSLGTLSD LSDCEGRLFP
1760 1770 1780 1790 1800
IGYQCSRLYW STVDARRRCW YRCRILEYRP WGPREEPVHL EAAEENQTIV
1810 1820 1830 1840 1850
HSPAPCSEPP DHVDPPPDTD ALIPRAPEHH PPVQNPDPPP RLDPSSAPPP
1860 1870 1880 1890 1900
APRSFSGARI KVPNYSPSRR PLGGVSFGPL PSPGSPSSLT HHIPTVGDPD
1910 1920 1930 1940 1950
FPAPPRRSRR PSPLASRLPP SRRASPPLRT SPQLRVPPPT SVVRALTPTS
1960 1970 1980 1990 2000
GELAPPSRAP SPPPPPEDLG PDFEDMEVVS GLSAADLDFA ASLLGTEPFQ
2010 2020 2030 2040 2050
EEIVAAGAGG SSHGGLGDSS EEEAGPTPRY VHFPVTVVSG PALAPGALPG
2060 2070 2080 2090 2100
APRIEQLDGV DDGTDSEAEA VQQPRGQGTP TSGPGAGRAG VIGAAGDRAR
2110 2120 2130 2140 2150
PPEDLPSEIV DFVLKNLGGP GEGGAGPREE PLPPAPPLAN GSQPPQGLPP
2160 2170 2180 2190 2200
NPADPTRTFA WLPGPPGVRV LSLGPAPEPP KPAASKIILV NKLGQVFVKM
2210 2220 2230 2240 2250
AGEGEPVSPP VKPPPLPPPM PPTAPTSWTL PPGPLLGVLP VVGVVRPAPP
2260 2270 2280 2290 2300
PPPPPLTLVL SSGPPSPPRQ AIRVKRVSTF SGRSPPAPPP SKTPRLEEDG
2310 2320 2330 2340 2350
ESLEDPPQGP GPCGSGFSRV RMKTPTVRGV LDLDDSGELT AEESPRPLQD
2360 2370 2380 2390 2400
RSPLLPLPEG GPPRAPDGPP DLLLESQWHH YSGEASSSEE EPPSPEDKEN
2410 2420 2430 2440 2450
QAPKRAGPHL RFEISSEDGF SVEAESLEGA WRTLIEKVQE ARGHARLRHL
2460 2470 2480 2490 2500
SFSGMSGARL LGIHHDAVIF LAEQLPGAQR CQHYKFRYHQ QGEGQEEPPL
2510 2520 2530 2540 2550
NPHGAARAEV YLRKCTFDMF NFLASQHRVL PEGATCDEEE DEVQLRSTRR
2560 2570 2580 2590 2600
ATSLELPMAM RFRHLKKTSK EAVGVYRSAI HGRGLFCKRN IDAGEMVIEY
2610 2620 2630 2640 2650
SGIVIRSVLT DKREKFYDGK GIGCYMFRMD DFDVVDATMH GNAARFINHS
2660 2670 2680 2690 2700
CEPNCFSRVI HVEGQKHIVI FALRRILRGE ELTYDYKFPI EDASNKLPCN
2710
CGAKRCRRFL N
Length:2,711
Mass (Da):293,366
Last modified:November 16, 2011 - v2
Checksum:iBED4A79F7DA60E24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046952 Genomic DNA. No translation available.
RefSeqiXP_003587289.1. XM_003587241.3.

Genome annotation databases

EnsembliENSBTAT00000003584; ENSBTAP00000003584; ENSBTAG00000002763.
GeneIDi785776.
KEGGibta:785776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046952 Genomic DNA. No translation available.
RefSeqiXP_003587289.1. XM_003587241.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003584; ENSBTAP00000003584; ENSBTAG00000002763.
GeneIDi785776.
KEGGibta:785776.

Organism-specific databases

CTDi9757.

Phylogenomic databases

GeneTreeiENSGT00760000119228.
InParanoidiE1BKN0.
KOiK14959.
OMAiWTSLTRE.
OrthoDBiEOG73RBBN.
TreeFamiTF319820.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 5 hits.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS51058. ZF_CXXC. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiE1BKN0_BOVIN
AccessioniPrimary (citable) accession number: E1BKN0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 16, 2011
Last modified: July 22, 2015
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.